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Discovery of Highly Potent, Selective, and Brain-Penetrable Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors

Journal of medicinal chemistry, 2012-11, Vol.55 (22), p.9416-9433

2012

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The emerging importance of predictive ADME simulation in drug discovery

Drug Discovery Today, 2002-01, Vol.7 (2), p.109-116

2002

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ADME/PK as part of a rational approach to drug discovery

Drug Discovery Today, 2000-09, Vol.5 (9), p.409-414

2000

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Focus on success: using a probabilistic approach to achieve an optimal balance of compound properties in drug discovery

Expert opinion on drug metabolism & toxicology, 2006-04, Vol.2 (2), p.325-337

2006

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Dihydropyrancarboxamides Related to Zanamivir: A New Series of Inhibitors of Influenza Virus Sialidases. 1. Discovery, Synthesis, Biological Activity, and Structure−Activity Relationships of 4-Guanidino- and 4-Amino-4H-pyran-6-carboxamides

Journal of medicinal chemistry, 1998-03, Vol.41 (6), p.787-797

1998

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Development of a Series of Aryl Pyrimidine Kynurenine Monooxygenase Inhibitors as Potential Therapeutic Agents for the Treatment of Huntington’s Disease

Journal of medicinal chemistry, 2015-02, Vol.58 (3), p.1159-1183

2015

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Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond – Part 2

Bioorganic & medicinal chemistry letters, 2019-02, Vol.29 (4), p.674-680

2019

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Integrated thermal management of a 150kW pilot Open Compute Project style data center

2019 IEEE 17th International Conference on Industrial Informatics (INDIN), 2019, Vol.1, p.1443-1450

2019

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IEEE_Xplore

Discovery of a Highly Selective, Brain-Penetrant Aminopyrazole LRRK2 Inhibitor

ACS medicinal chemistry letters, 2013-01, Vol.4 (1), p.85-90

2013

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In silico prediction of ADME properties: are we making progress?

Current opinion in drug discovery & development, 2004-01, Vol.7 (1), p.36

2004

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Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102

Toxicology (Amsterdam), 1999-11, Vol.139 (1), p.53-79

1999

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The design and preparation of metabolically protected new arylpiperazine 5-HT1A ligands

Bioorganic & medicinal chemistry letters, 2004-04, Vol.14 (7), p.1709-1712

2004

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The design and preparation of metabolically protected new arylpiperazine 5-HT 1A ligands

Bioorganic & medicinal chemistry letters, 2004, Vol.14 (7), p.1709-1712

2004

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CYP1A1: Friend or Foe?

Drug metabolism reviews, 1993, Vol.25 (4), p.503-517

Beresford, Alan P.

1993

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MODIFIED PEPTIDE ANTAGONISTS OF INTERLEUKIN 5 EXHIBIT EXTENDED IN VIVO PERSISTENCE BUT RESTRICTED SPECIES SPECIFICITY

Cytokine (Philadelphia, Pa.), 2001-07, Vol.15 (1), p.10-19

2001

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A SIMPLE MOBILITY PROGRAMME FOR PROFOUNDLY HANDICAPPED ADULTS

Apex (Kidderminster), 1978-09, Vol.6 (2), p.19-21

1978

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The Design and Preparation of Metabolically Protected New Arylpiperazine 5‐HT 1A Ligands

ChemInform, 2004-08, Vol.35 (33)

2004

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The Design and Preparation of Metabolically Protected New Arylpiperazine 5-HT1A Ligands

ChemInform, 2004-08, Vol.35 (33), p.no-no

2004

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The development of a generative computer assisted instruction system for drill and practice in elementary math

Beresford, Richard Alan

1974

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ProQuest

Adherence to WCRF/AICR Cancer Prevention Recommendations and Risk of Postmenopausal Breast Cancer

Cancer epidemiology, biomarkers & prevention, 2013-09, Vol.22 (9), p.1498-1508

2013

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Forage grasses with lower uptake of caesium and strontium could provide 'safer' crops for radiologically contaminated areas

PloS one, 2017-05, Vol.12 (5), p.e0176040-e0176040

2017

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10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer

The New England journal of medicine, 2016-10, Vol.375 (15), p.1415-1424

2016

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GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models

The Journal of pharmacology and experimental therapeutics, 2007-06, Vol.321 (3), p.1032

2007

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Discovery of Highly Potent, Selective, and Brain-Penetrable Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors

The emerging importance of predictive ADME simulation in drug discovery

ADME/PK as part of a rational approach to drug discovery

Focus on success: using a probabilistic approach to achieve an optimal balance of compound properties in drug discovery

Dihydropyrancarboxamides Related to Zanamivir: A New Series of Inhibitors of Influenza Virus Sialidases. 1. Discovery, Synthesis, Biological Activity, and Structure−Activity Relationships of 4-Guanidino- and 4-Amino-4H-pyran-6-carboxamides

Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors

Development of a Series of Aryl Pyrimidine Kynurenine Monooxygenase Inhibitors as Potential Therapeutic Agents for the Treatment of Huntington’s Disease

Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond – Part 2

Integrated thermal management of a 150kW pilot Open Compute Project style data center

Discovery of a Highly Selective, Brain-Penetrant Aminopyrazole LRRK2 Inhibitor

In silico prediction of ADME properties: are we making progress?

Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102

The design and preparation of metabolically protected new arylpiperazine 5-HT1A ligands

The design and preparation of metabolically protected new arylpiperazine 5-HT 1A ligands

CYP1A1: Friend or Foe?

MODIFIED PEPTIDE ANTAGONISTS OF INTERLEUKIN 5 EXHIBIT EXTENDED IN VIVO PERSISTENCE BUT RESTRICTED SPECIES SPECIFICITY

Dihydropyrancarboxamides Related to Zanamivir: A New Series of Inhibitors of Influenza Virus Sialidases. 1. Discovery, Synthesis, Biological Activity, and Structure−Activity Relationships of 4-Guanidino- and 4-Amino-4 H -pyran-6-carboxamides

A SIMPLE MOBILITY PROGRAMME FOR PROFOUNDLY HANDICAPPED ADULTS

The Design and Preparation of Metabolically Protected New Arylpiperazine 5‐HT 1A Ligands

The Design and Preparation of Metabolically Protected New Arylpiperazine 5-HT1A Ligands

The development of a generative computer assisted instruction system for drill and practice in elementary math

Adherence to WCRF/AICR Cancer Prevention Recommendations and Risk of Postmenopausal Breast Cancer

Forage grasses with lower uptake of caesium and strontium could provide 'safer' crops for radiologically contaminated areas

10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer

GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models

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