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NM 283, AN EFFICIENT PRODRUG OF THE POTENT ANTI-HCV AGENT 2′-C-METHYLCYTIDINE

Nucleosides, nucleotides & nucleic acids, 2005-01, Vol.24 (5-7), p.767-770

2005

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Synthesis and Pharmacokinetics of Valopicitabine (NM283), an Efficient Prodrug of the Potent Anti-HCV Agent 2‘-C-Methylcytidine

Journal of medicinal chemistry, 2006-11, Vol.49 (22), p.6614-6620

2006

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Conformationally Constrained Analogues of Diacylglycerol. 18. The Incorporation of a Hydroxamate Moiety into Diacylglycerol-Lactones Reduces Lipophilicity and Helps Discriminate between sn-1 and sn-2 Binding Modes to Protein Kinase C (PK-C). Implications for Isozyme Specificity

Journal of medicinal chemistry, 2001-12, Vol.44 (25), p.4309-4312

2001

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4′- C -Methyl-β-D-ribofuranosyl Purine and Pyrimidine Nucleosides Revisited

Nucleosides, nucleotides & nucleic acids, 2003-10, Vol.22 (5-8), p.707-709

2003

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Monoval-LdC: Efficient Prodrug of 2′-Deoxy-β-L-cytidine (L-dC), A Potent and Selective Anti-HBV Agent

Nucleosides, nucleotides & nucleic acids, 2003-10, Vol.22 (5-8), p.1003-1006

2003

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SYNTHESIS OF 5-ALKENYLATED D4T ANALOGUES VIA THE Pd-CATALYZED CROSS-COUPLING REACTION

Nucleosides, nucleotides & nucleic acids, 2001-09, Vol.20 (9), p.1655-1670

2001

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Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers

Pharmaceutical research, 1998-02, Vol.15 (2), p.239-245

1998

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Synthesis and Antiviral Activity of C-5 Substituted Analogues of D4T Bearing Methylamino- or Methyldiamino-Linker Arms

Nucleosides, nucleotides & nucleic acids, 2000-05, Vol.19 (5-6), p.1017-1031

2000

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Synthesis and Antiviral Activity of C-5 Substituted β-D- and β-L-D4T Analogues

Nucleosides, nucleotides & nucleic acids, 2000-09, Vol.19 (9), p.1441-1461

2000

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Conformationally Constrained Analogues of Diacylglycerol (DAG). 16. How Much Structural Complexity Is Necessary for Recognition and High Binding Affinity to Protein Kinase C?

Journal of medicinal chemistry, 2000-03, Vol.43 (5), p.921-944

2000

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bis(S-Acyl-2-thioethyl)esters of 2′,3′-Dideoxyadenosine 5′-Monophosphate Are Potent Anti-HIV Agents in Cell Culture

Nucleosides & nucleotides, 1995-05, Vol.14 (3-5), p.789-791

1995

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Synthesis, in Vitro Antiviral Evaluation, and Stability Studies of Bis(S-acyl-2-thioethyl) Ester Derivatives of 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) as Potential PMEA Prodrugs with Improved Oral Bioavailability

Journal of medicinal chemistry, 1996-12, Vol.39 (25), p.4958-4965

1996

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New Prodrugs of 9-(2-Phosphonomethoxyethyl)adenine [PMEA]: Synthesis and Stability Studies

Nucleosides & nucleotides, 1995-05, Vol.14 (3-5), p.563-565

1995

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The Transition from a Pharmacophore-Guided Approach to a Receptor-Guided Approach in the Design of Potent Protein Kinase C Ligands

Pharmacology & therapeutics (Oxford), 1999-05, Vol.82 (2), p.251-261

1999

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Rational design for cytosolic delivery of nucleoside monophosphates : SATE and DTE as enzyme-labile transient phosphate protecting groups

Bioorganic & medicinal chemistry letters, 1993-12, Vol.3 (12), p.2521-2526

1993

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Synthesis of 2′,3′,5′-trideoxyuridine-5′-methylphosphonic Acid and its Diphosphate Derivative. Study of the Interaction with HIV-1 reverse Transcriptase

Antiviral chemistry & chemotherapy, 1994-08, Vol.5 (4), p.221-228

1994

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Conformationally Constrained Analogues of Diacylglycerol. 18. The Incorporation of a Hydroxamate Moiety into Diacylglycerol-Lactones Reduces Lipophilicity and Helps Discriminate between sn-1 and sn-2 Binding Modes to Protein Kinase C (PK-C). Implications for Isozyme Specificity

Journal of medicinal chemistry, 2003-06, Vol.46 (13), p.2794-2794

2003

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Equal inhibition of the replication of human immunodeficiency virus in human T-cell culture by ddA BIS(SATE)phosphotriester and 3′-azido-2′,3′-dideoxythymidine

Biochemical pharmacology, 1994-07, Vol.48 (1), p.11-14

1994

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NM 283 has potent antiviral activity against genotype 1 chronic hepatitis C virus (HCV-1) infection in the chimpanzee

Journal of hepatology, 2003-04, Vol.38, p.3-3

2003

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Synthesis, physicochemical and pharmacokinetic studies of potential prodrugs of b-l-2'-deoxycytidine, a selective and specific anti-HBV agent

Antiviral chemistry & chemotherapy, 2004-09, Vol.15 (5), p.269-279

2004

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Conformationally constrained analogues of diacylglycerol (DAG). 15. The indispensable role of the sn-1 and sn-2 carbonyls in the binding of DAG-lactones to protein kinase C (PK-C)

Bioorganic & medicinal chemistry letters, 1998-12, Vol.8 (23), p.3403-3408

1998

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New insights regarding the potential of the pronucleotide approach in antiviral chemotherapy

Acta biochimica polonica, 1996-01, Vol.43 (1), p.196-208

1996

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Anti-human immunodeficiency virus type 1 activities of dideoxynucleoside phosphotriester derivatives in primary monocytes/macrophages

Research in virology (Paris), 1996-03, Vol.147 (2), p.155-163

1996

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New insights regarding the potential of the pronucleotide approach in antiviral chemotherapy

Acta biochimica polonica, 1996-01, Vol.43 (1), p.196-208

1996

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Monoval-LdC: Efficient Prodrug of 2′-Deoxy-β-L-cytidine (L-dC), a Potent and Selective anti-HBV Agent

ChemInform, 2004-02, Vol.35 (5), p.no-no

2004

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NM 283, AN EFFICIENT PRODRUG OF THE POTENT ANTI-HCV AGENT 2′-C-METHYLCYTIDINE

Synthesis and Pharmacokinetics of Valopicitabine (NM283), an Efficient Prodrug of the Potent Anti-HCV Agent 2‘-C-Methylcytidine

Conformationally Constrained Analogues of Diacylglycerol. 18. The Incorporation of a Hydroxamate Moiety into Diacylglycerol-Lactones Reduces Lipophilicity and Helps Discriminate between sn-1 and sn-2 Binding Modes to Protein Kinase C (PK-C). Implications for Isozyme Specificity

4′- C -Methyl-β-D-ribofuranosyl Purine and Pyrimidine Nucleosides Revisited

Monoval-LdC: Efficient Prodrug of 2′-Deoxy-β-L-cytidine (L-dC), A Potent and Selective Anti-HBV Agent

SYNTHESIS OF 5-ALKENYLATED D4T ANALOGUES VIA THE Pd-CATALYZED CROSS-COUPLING REACTION

Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers

Synthesis and Antiviral Activity of C-5 Substituted Analogues of D4T Bearing Methylamino- or Methyldiamino-Linker Arms

Synthesis and Antiviral Activity of C-5 Substituted β-D- and β-L-D4T Analogues

Conformationally Constrained Analogues of Diacylglycerol (DAG). 16. How Much Structural Complexity Is Necessary for Recognition and High Binding Affinity to Protein Kinase C?

bis(S-Acyl-2-thioethyl)esters of 2′,3′-Dideoxyadenosine 5′-Monophosphate Are Potent Anti-HIV Agents in Cell Culture

Synthesis, in Vitro Antiviral Evaluation, and Stability Studies of Bis(S-acyl-2-thioethyl) Ester Derivatives of 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) as Potential PMEA Prodrugs with Improved Oral Bioavailability

New Prodrugs of 9-(2-Phosphonomethoxyethyl)adenine [PMEA]: Synthesis and Stability Studies

The Transition from a Pharmacophore-Guided Approach to a Receptor-Guided Approach in the Design of Potent Protein Kinase C Ligands

Rational design for cytosolic delivery of nucleoside monophosphates : SATE and DTE as enzyme-labile transient phosphate protecting groups

Synthesis of 2′,3′,5′-trideoxyuridine-5′-methylphosphonic Acid and its Diphosphate Derivative. Study of the Interaction with HIV-1 reverse Transcriptase

Conformationally Constrained Analogues of Diacylglycerol. 18. The Incorporation of a Hydroxamate Moiety into Diacylglycerol-Lactones Reduces Lipophilicity and Helps Discriminate between sn-1 and sn-2 Binding Modes to Protein Kinase C (PK-C). Implications for Isozyme Specificity

Equal inhibition of the replication of human immunodeficiency virus in human T-cell culture by ddA BIS(SATE)phosphotriester and 3′-azido-2′,3′-dideoxythymidine

NM 283 has potent antiviral activity against genotype 1 chronic hepatitis C virus (HCV-1) infection in the chimpanzee

Synthesis, physicochemical and pharmacokinetic studies of potential prodrugs of b-l-2'-deoxycytidine, a selective and specific anti-HBV agent

Conformationally constrained analogues of diacylglycerol (DAG). 15. The indispensable role of the sn-1 and sn-2 carbonyls in the binding of DAG-lactones to protein kinase C (PK-C)

New insights regarding the potential of the pronucleotide approach in antiviral chemotherapy

Anti-human immunodeficiency virus type 1 activities of dideoxynucleoside phosphotriester derivatives in primary monocytes/macrophages

New insights regarding the potential of the pronucleotide approach in antiviral chemotherapy

Monoval-LdC: Efficient Prodrug of 2′-Deoxy-β-L-cytidine (L-dC), a Potent and Selective anti-HBV Agent

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