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Quantitative Systems Pharmacology and Empirical Models: Friends or Foes?

CPT: pharmacometrics and systems pharmacology, 2019-03, Vol.8 (3), p.135-137

Benson, Neil

2019

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A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins

CPT: pharmacometrics and systems pharmacology, 2019-11, Vol.8 (11), p.773-776

2019

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Network-based discovery through mechanistic systems biology. Implications for applications – SMEs and drug discovery: where the action is

Drug discovery today. Technologies, 2015-08, Vol.15, p.41-48

Benson, Neil

2015

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Systems Pharmacology: Bridging Systems Biology and Pharmacokinetics-Pharmacodynamics (PKPD) in Drug Discovery and Development

Pharmaceutical research, 2011-07, Vol.28 (7), p.1460-1464

2011

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Pharmacokinetic-Pharmacodynamic Modeling of Alpha Interferon Response Induced by a Toll-Like 7 Receptor Agonist in Mice

Antimicrobial Agents and Chemotherapy, 2010-03, Vol.54 (3), p.1179-1185

2010

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First-in-human phase I study of the bromodomain and extraterminal motif inhibitor BAY 1238097: emerging pharmacokinetic/pharmacodynamic relationship and early termination due to unexpected toxicity

European journal of cancer (1990), 2019-03, Vol.109, p.103-110

2019

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The Role of Quantitative Systems Pharmacology in the Design of First‐in‐Human Trials

Clinical pharmacology and therapeutics, 2018-11, Vol.104 (5), p.797-797

2018

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Use of mathematics to guide target selection in systems pharmacology; application to receptor tyrosine kinase (RTK) pathways

European journal of pharmaceutical sciences, 2017-11, Vol.109, p.S140-S148

2017

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Selecting optimal drug-intervention in a pathway involving receptor tyrosine kinases (RTKs)

Nonlinear analysis, 2016-05, Vol.137, p.148-170

2016

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Exposure to dietary mercury alters cognition and behavior of zebra finches

Current zoology, 2017-04, Vol.63 (2), p.213-219

2017

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Topics in Mathematical Pharmacology

Journal of dynamics and differential equations, 2016-09, Vol.28 (3-4), p.1337-1356

2016

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Quantitative Systems Pharmacology Model for Alzheimer Disease Indicates Targeting Sphingolipid Dysregulation as Potential Treatment Option

CPT: pharmacometrics and systems pharmacology, 2018-11, Vol.7 (11), p.759-770

2018

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The rise of systems pharmacology in drug discovery and development

Future medicinal chemistry, 2014-01, Vol.6 (16), p.1731-1734

2014

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Prediction of long-term treatment outcome in HCV following 24 day PEG-IFN alpha-2b therapy using population pharmacokinetic-pharmacodynamic mixture modeling and classification analysis

Journal of theoretical biology, 2015-10, Vol.382, p.91-98

2015

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Cross-membrane signal transduction of receptor tyrosine kinases (RTKs): from systems biology to systems pharmacology

Journal of mathematical biology, 2013-03, Vol.66 (4-5), p.719-742

2013

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Impact of plasma-protein binding on receptor occupancy: An analytical description

Journal of theoretical biology, 2009-01, Vol.256 (2), p.253-262

2009

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Impact of protein binding on receptor occupancy: A two-compartment model

Journal of theoretical biology, 2010-08, Vol.265 (4), p.657-671

2010

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Peripheral Blood CD34+ Specific Donor Chimerism Analysis As an Early Indicator of Disease Relapse After Allogeneic Hematopoietic Stem Cell Transplant in Patients with Myelodysplastic Syndromes and Acute Myelogenous Leukemia

Blood, 2012-11, Vol.120 (21), p.3074-3074

2012

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Systems pharmacology of the nerve growth factor pathway: use of a systems biology model for the identification of key drug targets using sensitivity analysis and the integration of physiology and pharmacology

Interface focus, 2013-04, Vol.3 (2), p.20120071

2013

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Detection of the optical bands of molybdenum(V) in DMSO reductase ( Rhodobacter capsulatus) by low-temperature MCD spectroscopy

FEBS letters, 1992-07, Vol.307 (2), p.169-172

1992

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Design and optimisation of orally active TLR7 agonists for the treatment of hepatitis C virus infection

Bioorganic & medicinal chemistry letters, 2011-04, Vol.21 (8), p.2389-2393

2011

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Estimation of binding rate constants using a simultaneous mixed‐effects method: application to monoamine transporter reuptake inhibitor reboxetine

British journal of pharmacology, 2010-05, Vol.160 (2), p.389-398

2010

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Translational pharmacokinetic–pharmacodynamic modelling; application to cardiovascular safety data for PF‐00821385, a novel HIV agent

British journal of clinical pharmacology, 2010-04, Vol.69 (4), p.336-345

2010

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Modeling of celiac disease immune response and the therapeutic effect of potential drugs

BMC systems biology, 2013-07, Vol.7 (1), p.56-56

2013

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Proximate parameter tuning for biochemical networks with uncertain kinetic parameters

Molecular bioSystems, 2008-01, Vol.4 (1), p.74-97

2008

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Quantitative Systems Pharmacology and Empirical Models: Friends or Foes?

A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins

Network-based discovery through mechanistic systems biology. Implications for applications – SMEs and drug discovery: where the action is

Systems Pharmacology: Bridging Systems Biology and Pharmacokinetics-Pharmacodynamics (PKPD) in Drug Discovery and Development

Pharmacokinetic-Pharmacodynamic Modeling of Alpha Interferon Response Induced by a Toll-Like 7 Receptor Agonist in Mice

First-in-human phase I study of the bromodomain and extraterminal motif inhibitor BAY 1238097: emerging pharmacokinetic/pharmacodynamic relationship and early termination due to unexpected toxicity

The Role of Quantitative Systems Pharmacology in the Design of First‐in‐Human Trials

Use of mathematics to guide target selection in systems pharmacology; application to receptor tyrosine kinase (RTK) pathways

Selecting optimal drug-intervention in a pathway involving receptor tyrosine kinases (RTKs)

Exposure to dietary mercury alters cognition and behavior of zebra finches

Topics in Mathematical Pharmacology

Quantitative Systems Pharmacology Model for Alzheimer Disease Indicates Targeting Sphingolipid Dysregulation as Potential Treatment Option

The rise of systems pharmacology in drug discovery and development

Prediction of long-term treatment outcome in HCV following 24 day PEG-IFN alpha-2b therapy using population pharmacokinetic-pharmacodynamic mixture modeling and classification analysis

Cross-membrane signal transduction of receptor tyrosine kinases (RTKs): from systems biology to systems pharmacology

Impact of plasma-protein binding on receptor occupancy: An analytical description

Impact of protein binding on receptor occupancy: A two-compartment model

Peripheral Blood CD34+ Specific Donor Chimerism Analysis As an Early Indicator of Disease Relapse After Allogeneic Hematopoietic Stem Cell Transplant in Patients with Myelodysplastic Syndromes and Acute Myelogenous Leukemia

Systems pharmacology of the nerve growth factor pathway: use of a systems biology model for the identification of key drug targets using sensitivity analysis and the integration of physiology and pharmacology

Detection of the optical bands of molybdenum(V) in DMSO reductase ( Rhodobacter capsulatus) by low-temperature MCD spectroscopy

Design and optimisation of orally active TLR7 agonists for the treatment of hepatitis C virus infection

Estimation of binding rate constants using a simultaneous mixed‐effects method: application to monoamine transporter reuptake inhibitor reboxetine

Translational pharmacokinetic–pharmacodynamic modelling; application to cardiovascular safety data for PF‐00821385, a novel HIV agent

Modeling of celiac disease immune response and the therapeutic effect of potential drugs

Proximate parameter tuning for biochemical networks with uncertain kinetic parameters

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