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Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors

Translational psychiatry, 2021-02, Vol.11 (1), p.59-59, Article 59

2021

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Advances and challenges in the search for D2 and D3 dopamine receptor-selective compounds

Cellular signalling, 2018-01, Vol.41, p.75-81

2018

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New roles for dopamine D2 and D3 receptors in pancreatic beta cell insulin secretion

Molecular psychiatry, 2020-09, Vol.25 (9), p.2070-2085

2020

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A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity

Science signaling, 2020-02, Vol.13 (617)

2020

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Development of pyrimidone D1 dopamine receptor positive allosteric modulators

Bioorganic & medicinal chemistry letters, 2021-01, Vol.31, p.127696-127696, Article 127696

2021

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Structural basis for Na(+)-sensitivity in dopamine D2 and D3 receptors

Chemical communications (Cambridge, England), 2015-05, Vol.51 (41), p.8618-8621

2015

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Novel Cryo-EM structures of the D1 dopamine receptor unlock its therapeutic potential

Signal transduction and targeted therapy, 2021-05, Vol.6 (1), p.205-205, Article 205

2021

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Ligand with Two Modes of Interaction with the Dopamine D2 Receptor–An Induced-Fit Mechanism of Insurmountable Antagonism

ACS chemical neuroscience, 2020-10, Vol.11 (19), p.3130-3143

2020

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G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D2 Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation

Biomolecules (Basel, Switzerland), 2023-10, Vol.13 (10), p.1552

2023

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The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors

PLoS computational biology, 2018-01, Vol.14 (1), p.e1005948-e1005948

2018

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Advances and challenges in the search for D 2 and D 3 dopamine receptor-selective compounds

Cellular signalling, 2018-01, Vol.41, p.75

2018

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Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine

iScience, 2022-08, Vol.25 (8), p.104771-104771, Article 104771

2022

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D1 and D2 Dopamine Receptor Expression Is Regulated by Direct Interaction with the Chaperone Protein Calnexin

The Journal of biological chemistry, 2007-07, Vol.282 (29), p.21285-21300

2007

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Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D2 Dopamine Receptor

Frontiers in synaptic neuroscience, 2018-02, Vol.10, p.2-2

2018

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Pharmacological Characterization of the Imipridone Anticancer Drug ONC201 Reveals a Negative Allosteric Mechanism of Action at the D2 Dopamine Receptor

Molecular pharmacology, 2021-10, Vol.100 (4), p.372-387

2021

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Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R)

Journal of medicinal chemistry, 2017-02, Vol.60 (4), p.1478-1494

2017

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D1-D2 dopamine receptor synergy promotes calcium signaling via multiple mechanisms

Molecular pharmacology, 2013-08, Vol.84 (2), p.190-200

2013

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Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist

Journal of medicinal chemistry, 2020-05, Vol.63 (10), p.5526-5567

2020

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Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D 3 Receptor (D 3 R)

Journal of medicinal chemistry, 2017-02, Vol.60 (4), p.1478-1494

2017

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Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D 3 Dopamine Receptor Agonist

Journal of medicinal chemistry, 2020-05, Vol.63 (10), p.5526-5567

2020

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Identification of G Protein-Biased Agonists That Fail To Recruit β‑Arrestin or Promote Internalization of the D1 Dopamine Receptor

ACS chemical neuroscience, 2015-04, Vol.6 (4), p.681-692

2015

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Identification of Positive Allosteric Modulators of the D 1 Dopamine Receptor That Act at Diverse Binding Sites

Molecular pharmacology, 2018-10, Vol.94 (4), p.1197-1209

2018

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Novel Dopamine D4 Receptor‐Selective Antagonists For Neuropsychiatric Disorders

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Dopamine D4 Receptor-Selective Compounds Reveal Structure–Activity Relationships that Engender Agonist Efficacy

Journal of medicinal chemistry, 2019-04, Vol.62 (7), p.3722-3740

2019

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Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors

Advances and challenges in the search for D2 and D3 dopamine receptor-selective compounds

New roles for dopamine D2 and D3 receptors in pancreatic beta cell insulin secretion

A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity

Development of pyrimidone D1 dopamine receptor positive allosteric modulators

Structural basis for Na(+)-sensitivity in dopamine D2 and D3 receptors

Novel Cryo-EM structures of the D1 dopamine receptor unlock its therapeutic potential

Ligand with Two Modes of Interaction with the Dopamine D2 Receptor–An Induced-Fit Mechanism of Insurmountable Antagonism

G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D2 Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation

The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors

Advances and challenges in the search for D 2 and D 3 dopamine receptor-selective compounds

Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine

D1 and D2 Dopamine Receptor Expression Is Regulated by Direct Interaction with the Chaperone Protein Calnexin

Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D2 Dopamine Receptor

Pharmacological Characterization of the Imipridone Anticancer Drug ONC201 Reveals a Negative Allosteric Mechanism of Action at the D2 Dopamine Receptor

Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R)

D1-D2 dopamine receptor synergy promotes calcium signaling via multiple mechanisms

Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist

Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D 3 Receptor (D 3 R)

Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D 3 Dopamine Receptor Agonist

Identification of G Protein-Biased Agonists That Fail To Recruit β‑Arrestin or Promote Internalization of the D1 Dopamine Receptor

Identification of Positive Allosteric Modulators of the D 1 Dopamine Receptor That Act at Diverse Binding Sites

Novel Dopamine D4 Receptor‐Selective Antagonists For Neuropsychiatric Disorders

Dopamine D4 Receptor-Selective Compounds Reveal Structure–Activity Relationships that Engender Agonist Efficacy

Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder

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