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Model-based Drug Development

Clinical pharmacology and therapeutics, 2007-07, Vol.82 (1), p.21-32

2007

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Pharmacokinetics and pharmacodynamics of SB-240563, a humanized monoclonal antibody directed to human interleukin-5, in monkeys

The Journal of pharmacology and experimental therapeutics, 1999-12, Vol.291 (3), p.1060

1999

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Assessment of the Potential Pharmacokinetic and Pharmacodynamic Interactions between Erythromycin and Argatroban

Journal of clinical pharmacology, 1999-05, Vol.39 (5), p.513-519

1999

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Renal adaptation to altered dietary sulfate in rats

The Journal of pharmacology and experimental therapeutics, 1995-01, Vol.272 (1), p.248

1995

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Paroxetine does not affect the cardiac safety and pharmacokinetics of terfenadine in healthy adult men

Journal of clinical psychopharmacology, 1997-12, Vol.17 (6), p.451-459

1997

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Inhibition of sulfate transport in rat kidney membrane vesicle preparations by nonsteroidal antiinflammatory drugs

Drug metabolism and disposition, 1993-07, Vol.21 (4), p.750

1993

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Pharmacokinetics and pharmacodynamics of a humanized monoclonal antibody to factor IX in cynomolgus monkeys

The Journal of pharmacology and experimental therapeutics, 2000-02, Vol.292 (2), p.810

2000

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Influence of NSAID-Induced Inhibition of Renal Prostaglandin Synthesis on Inorganic Sulfate Clearance in Rats

Proceedings of the Society for Experimental Biology and Medicine, 1992-04, Vol.199 (4), p.410-416

1992

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Influence of dibutyryl-cAMP on ibuprofen-induced alterations of sulfate renal clearance in rats

Drug metabolism and disposition, 1992-05, Vol.20 (3), p.461

1992

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Tiaprofenic acid inhibits the renal reabsorption of sulfate in rats

Prostaglandins, leukotrienes and essential fatty acids, 1993-07, Vol.49 (1), p.503-508

1993

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Ibuprofen-induced changes in sulfate renal transport

The Journal of pharmacology and experimental therapeutics, 1998-12, Vol.287 (3), p.1092

1998

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An Overview of the Pharmacokinetics of Cilomilast (Ariflo®), a New, Orally Active Phosphodiesterase 4 Inhibitor, in Healthy Young and Elderly Volunteers

Journal of clinical pharmacology, 2001-09, Vol.41 (9), p.950-958

2001

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PHARMACOKINETICS AND ABSOLUTE BIOAVAILABILITY OF EPRISTERIDE IN HEALTHY MALE SUBJECTS

Biopharmaceutics & drug disposition, 1996-04, Vol.17 (3), p.249-258

1996

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Accumulation of Antibody-Target Complexes and the Pharmacodynamics of Clotting after Single Intravenous Administration of Humanized Anti-Factor IX Monoclonal Antibody to Rats

Drug delivery, 1999, Vol.6 (3), p.171-179

1999

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OIII-A-2

Clinical pharmacology and therapeutics, 2006-02, Vol.79 (2), p.P29-P29

2006

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Effects of acute caffeine ingestion and menopause on sulfate homeostasis in women

Life sciences (1973), 1995, Vol.57 (16), p.1497-1505

1995

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Sulfate homeostasis. II, Influence of chronic aspirin administration on inorganic sulfate in humans

Pharmaceutical research, 1990-07, Vol.7 (7), p.719-722

1990

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Pharmacokinetic and pharmacodynamic modeling of humanized anti-factor IX antibody (SB 249417) in humans

Clinical pharmacology and therapeutics, 2002-04, Vol.71 (4), p.235-245

2002

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Nonlinear Pharmacokinetics and Protein Binding of Tiaprofenic Acid in Female Lewis Rats

Journal of pharmaceutical sciences, 1993-04, Vol.82 (4), p.429-430

1993

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OIII-A-4

Clinical pharmacology and therapeutics, 2006-02, Vol.79 (2), p.P29-P29

2006

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An Overview of the Pharmacokinetics of Cilomilast (Ariflo®), a New, Orally Active Phosphodiesterase 4 Inhibitor, in Healthy Young and Elderly Volunteers

Journal of clinical pharmacology, 2001-09, Vol.41 (9), p.950-958

2001

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Pharmacokinetics and pharmacodynamics of azithromycin in gerbils with haemophilus influenzae middle ear infection

Clinical pharmacology and therapeutics, 2005-02, Vol.77 (2), p.P89-P89

2005

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Nonlinear mixed effects modeling of time dependencies in drug-free ECG data from healthy volunteers

Clinical pharmacology and therapeutics, 2004-02, Vol.75 (2), p.P97-P97

2004

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Population pharmacokinetic and pharmacodynamic model of CP-101,606 following a 72-hour infusion in acute ischemic stroke patients

Clinical pharmacology and therapeutics, 2004-02, Vol.75 (2), p.P97-P97

2004

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Concentration-QTC modeling in healthy volunteers (HV) and in subjects with major depressive disorder (MDD) for a novel antidepressant candidate

Clinical pharmacology and therapeutics, 2004-02, Vol.75 (2), p.P88-P88

2004

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Model-based Drug Development

Pharmacokinetics and pharmacodynamics of SB-240563, a humanized monoclonal antibody directed to human interleukin-5, in monkeys

Assessment of the Potential Pharmacokinetic and Pharmacodynamic Interactions between Erythromycin and Argatroban

Renal adaptation to altered dietary sulfate in rats

Paroxetine does not affect the cardiac safety and pharmacokinetics of terfenadine in healthy adult men

Inhibition of sulfate transport in rat kidney membrane vesicle preparations by nonsteroidal antiinflammatory drugs

Pharmacokinetics and pharmacodynamics of a humanized monoclonal antibody to factor IX in cynomolgus monkeys

Influence of NSAID-Induced Inhibition of Renal Prostaglandin Synthesis on Inorganic Sulfate Clearance in Rats

Influence of dibutyryl-cAMP on ibuprofen-induced alterations of sulfate renal clearance in rats

Tiaprofenic acid inhibits the renal reabsorption of sulfate in rats

Ibuprofen-induced changes in sulfate renal transport

An Overview of the Pharmacokinetics of Cilomilast (Ariflo®), a New, Orally Active Phosphodiesterase 4 Inhibitor, in Healthy Young and Elderly Volunteers

PHARMACOKINETICS AND ABSOLUTE BIOAVAILABILITY OF EPRISTERIDE IN HEALTHY MALE SUBJECTS

Accumulation of Antibody-Target Complexes and the Pharmacodynamics of Clotting after Single Intravenous Administration of Humanized Anti-Factor IX Monoclonal Antibody to Rats

OIII-A-2

Effects of acute caffeine ingestion and menopause on sulfate homeostasis in women

Sulfate homeostasis. II, Influence of chronic aspirin administration on inorganic sulfate in humans

Pharmacokinetic and pharmacodynamic modeling of humanized anti-factor IX antibody (SB 249417) in humans

Nonlinear Pharmacokinetics and Protein Binding of Tiaprofenic Acid in Female Lewis Rats

OIII-A-4

An Overview of the Pharmacokinetics of Cilomilast (Ariflo®), a New, Orally Active Phosphodiesterase 4 Inhibitor, in Healthy Young and Elderly Volunteers

Pharmacokinetics and pharmacodynamics of azithromycin in gerbils with haemophilus influenzae middle ear infection

Nonlinear mixed effects modeling of time dependencies in drug-free ECG data from healthy volunteers

Population pharmacokinetic and pharmacodynamic model of CP-101,606 following a 72-hour infusion in acute ischemic stroke patients

Concentration-QTC modeling in healthy volunteers (HV) and in subjects with major depressive disorder (MDD) for a novel antidepressant candidate

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