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Arylpiperazine Derivatives Acting at 5-HT1A Receptors

Current medicinal chemistry, 2002-02, Vol.9 (4), p.443-469

2002

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269 Molecular interplay between cancer cell fatty acid metabolism and oncogenic signaling as resource for novel treatment strategies against ovarian cancer

European journal of cancer (1990), 2015-09, Vol.51, p.S49-S49

2015

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Optimization of the Pharmacophore Model for 5-HT7R Antagonism. Design and Synthesis of New Naphtholactam and Naphthosultam Derivatives

Journal of medicinal chemistry, 2003-12, Vol.46 (26), p.5638-5650

2003

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5-HT4 Receptor Antagonists: Structure-Affinity Relationships and Ligand- Receptor Interactions

Current topics in medicinal chemistry, 2002-06, Vol.2 (6), p.625-641

2002

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Benzimidazole Derivatives. 3. 3D-QSAR/CoMFA Model and Computational Simulation for the Recognition of 5-HT4 Receptor Antagonists

Journal of medicinal chemistry, 2002-10, Vol.45 (22), p.4806-4815

2002

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First pharmacophoric hypothesis for 5-HT7 antagonism

Bioorganic & medicinal chemistry letters, 2000-05, Vol.10 (10), p.1097-1100

2000

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Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors

European journal of pharmacology, 2005-03, Vol.511 (1), p.9-19

2005

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Synthesis and structure-activity relationships of a new model of arylpiperazines. Part 7: Study of the influence of lipophilic factors at the terminal amide fragment on 5-HT1A affinity/selectivity

Bioorganic & medicinal chemistry, 2004-03, Vol.12 (6), p.1551-1557

2004

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Benzimidazole derivatives. Part 5: Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands

Bioorganic & medicinal chemistry, 2004-10, Vol.12 (19), p.5181-5191

2004

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Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 1. 2-[[4-(o-Methoxyphenyl)piperazin-1-yl]methyl]-1,3- dioxoperhydroimidazo[1,5-a]pyridine: A Selective 5-HT1A Receptor Agonist

Journal of medicinal chemistry, 1996-10, Vol.39 (22), p.4439-4450

1996

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Computational model of the complex between GR113808 and the 5-HT4 receptor guided by site-directed mutagenesis and the crystal structure of rhodopsin

Journal of computer-aided molecular design, 2001-11, Vol.15 (11), p.1025

2001

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Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]-methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist

Bioorganic & medicinal chemistry letters, 2003-04, Vol.13 (8), p.1429-1432

2003

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Benzimidazole derivatives. Part 1: Synthesis and structure–activity relationships of new benzimidazole-4-carboxamides and carboxylates as potent and selective 5-HT4 receptor antagonists

Bioorganic & medicinal chemistry, 1999-11, Vol.7 (11), p.2271-2281

1999

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Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands

Bioorganic & medicinal chemistry letters, 2003-10, Vol.13 (19), p.3177-3180

2003

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Anxiolytic-like effect of a serotonergic ligand with high affinity for 5- HT sub(1A), 5-HT sub(2A) and 5-HT sub(3) receptors

European journal of pharmacology, 2005-03, Vol.511 (1), p.9-19

2005

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3-D-QSAR/CoMFA and recognition models of benzimidazole derivatives at the 5-HT4 receptor

Bioorganic & medicinal chemistry letters, 2001-11, Vol.11 (21), p.2807-2811

2001

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New benzimidazole derivatives: selective and orally active 5-HT3 receptor antagonists

European journal of pharmacology, 2003-02, Vol.462 (1-3), p.99-107

2003

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Synthesis and Structure-Activity Relationships of a New Model of Arylpiperazines. 8. super(1) Computational Simulation of Ligand-Receptor Interaction of 5-HT sub(1A)R Agonists with Selectivity over alpha sub(1)-Adrenoceptors

Journal of medicinal chemistry, 2005-04, Vol.48 (7), p.2548-2558

2005

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PF467 NEW MOLECULES INSPIRED ON MICROBIOTA METABOLITES TARGETING ACUTE MYELOID LEUKEMIA CELLS

HemaSphere, 2019-06, Vol.3, p.184-185

2019

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5-HT(4) receptor antagonists: structure-affinity relationships and ligand-receptor interactions

Current topics in medicinal chemistry, 2002-06, Vol.2 (6), p.625

2002

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Benzimidazole derivatives. 4. The recognition of the voluminous substituent attached to the basic amino group of 5-HT sub(4) receptor antagonists

Journal of computer-aided molecular design, 2003-08, Vol.17 (8), p.515-524

2003

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Benzimidazole Derivatives. 2. Synthesis and Structure−Activity Relationships of New Azabicyclic Benzimidazole-4-carboxylic Acid Derivatives with Affinity for Serotoninergic 5-HT3 Receptors

Journal of medicinal chemistry, 1999-12, Vol.42 (24), p.5020-5028

1999

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Pd(0) Amination of Benzimidazoles as an Efficient Method towards New (Benzimidazolyl)piperazines with High Affinity for the 5-HT1A Receptor

Tetrahedron, 2000-05, Vol.56 (20), p.3245-3253

2000

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Comparative receptor mapping of serotoninergic 5-HT3 and 5-HT4 binding sites

Journal of computer-aided molecular design, 1997-11, Vol.11 (6), p.589

1997

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Synthesis of new (benzimidazolyl)piperazines with affinity for the 5-HT1A receptor via Pd(0) amination of bromobenzimidazoles

Bioorganic & medicinal chemistry letters, 1999-08, Vol.9 (16), p.2339-2342

1999

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Arylpiperazine Derivatives Acting at 5-HT1A Receptors

269 Molecular interplay between cancer cell fatty acid metabolism and oncogenic signaling as resource for novel treatment strategies against ovarian cancer

Optimization of the Pharmacophore Model for 5-HT7R Antagonism. Design and Synthesis of New Naphtholactam and Naphthosultam Derivatives

5-HT4 Receptor Antagonists: Structure-Affinity Relationships and Ligand- Receptor Interactions

Benzimidazole Derivatives. 3. 3D-QSAR/CoMFA Model and Computational Simulation for the Recognition of 5-HT4 Receptor Antagonists

First pharmacophoric hypothesis for 5-HT7 antagonism

Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors

Synthesis and structure-activity relationships of a new model of arylpiperazines. Part 7: Study of the influence of lipophilic factors at the terminal amide fragment on 5-HT1A affinity/selectivity

Benzimidazole derivatives. Part 5: Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands

Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 1. 2-[[4-(o-Methoxyphenyl)piperazin-1-yl]methyl]-1,3- dioxoperhydroimidazo[1,5-a]pyridine: A Selective 5-HT1A Receptor Agonist

Computational model of the complex between GR113808 and the 5-HT4 receptor guided by site-directed mutagenesis and the crystal structure of rhodopsin

Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]-methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist

Benzimidazole derivatives. Part 1: Synthesis and structure–activity relationships of new benzimidazole-4-carboxamides and carboxylates as potent and selective 5-HT4 receptor antagonists

Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands

Anxiolytic-like effect of a serotonergic ligand with high affinity for 5- HT sub(1A), 5-HT sub(2A) and 5-HT sub(3) receptors

3-D-QSAR/CoMFA and recognition models of benzimidazole derivatives at the 5-HT4 receptor

New benzimidazole derivatives: selective and orally active 5-HT3 receptor antagonists

Synthesis and Structure-Activity Relationships of a New Model of Arylpiperazines. 8. super(1) Computational Simulation of Ligand-Receptor Interaction of 5-HT sub(1A)R Agonists with Selectivity over alpha sub(1)-Adrenoceptors

PF467 NEW MOLECULES INSPIRED ON MICROBIOTA METABOLITES TARGETING ACUTE MYELOID LEUKEMIA CELLS

5-HT(4) receptor antagonists: structure-affinity relationships and ligand-receptor interactions

Benzimidazole derivatives. 4. The recognition of the voluminous substituent attached to the basic amino group of 5-HT sub(4) receptor antagonists

Benzimidazole Derivatives. 2. Synthesis and Structure−Activity Relationships of New Azabicyclic Benzimidazole-4-carboxylic Acid Derivatives with Affinity for Serotoninergic 5-HT3 Receptors

Pd(0) Amination of Benzimidazoles as an Efficient Method towards New (Benzimidazolyl)piperazines with High Affinity for the 5-HT1A Receptor

Comparative receptor mapping of serotoninergic 5-HT3 and 5-HT4 binding sites

Synthesis of new (benzimidazolyl)piperazines with affinity for the 5-HT1A receptor via Pd(0) amination of bromobenzimidazoles

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