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Targeted Degradation of Structured RNAs via Ribonuclease-Targeting Chimeras (RiboTacs)

Expert opinion on drug discovery, 2023-08, Vol.18 (8), p.929-942

2023

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Targeting the SARS-CoV‑2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders

ACS central science, 2020-10, Vol.6 (10), p.1713-1721

2020

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Di-N-Methylation of Anti-Gram-Positive Aminoglycoside-Derived Membrane Disruptors Improves Antimicrobial Potency and Broadens Spectrum to Gram-Negative Bacteria

Angewandte Chemie International Edition, 2015-11, Vol.54 (46), p.13617-13621

International ed. in English, 2015

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Targeting MicroRNAs with Small Molecules

Non-coding RNA, 2024-04, Vol.10 (2), p.17

2024

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Tuning the Effects of Bacterial Membrane Permeability through Photo‐Isomerization of Antimicrobial Cationic Amphiphiles

Chemistry : a European journal, 2017-09, Vol.23 (52), p.12724-12728

2017

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Fluorescent Tracking of the Endoplasmic Reticulum in Live Pathogenic Fungal Cells

ACS chemical biology, 2018-12, Vol.13 (12), p.3325-3332

2018

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Real-Time Imaging of the Azole Class of Antifungal Drugs in Live Candida Cells

ACS chemical biology, 2017-07, Vol.12 (7), p.1769-1777

2017

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Bacterial-derived exopolysaccharides enhance antifungal drug tolerance in a cross-kingdom oral biofilm

The ISME Journal, 2018-06, Vol.12 (6), p.1427-1442

2018

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Localizing Antifungal Drugs to the Correct Organelle Can Markedly Enhance their Efficacy

Angewandte Chemie International Edition, 2018-05, Vol.57 (21), p.6230-6235

International ed. in English, 2018

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Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment

Journal of the American Chemical Society, 2021-08, Vol.143 (33), p.13044-13055

2021

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Structural insights of lincosamides targeting the ribosome of Staphylococcus aureus

Nucleic acids research, 2017-09, Vol.45 (17), p.10284-10292

2017

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Programming inactive RNA-binding small molecules into bioactive degraders

Nature (London), 2023-06, Vol.618 (7963), p.169-179

2023

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Progress toward the development of the small molecule equivalent of small interfering RNA

Current opinion in chemical biology, 2020-06, Vol.56, p.63-71

2020

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Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles

European journal of medicinal chemistry, 2019-10, Vol.179, p.779-790

2019

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DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor

Proceedings of the National Academy of Sciences - PNAS, 2022-02, Vol.119 (6), p.1

2022

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A Druglike Small Molecule that Targets r(CCUG) Repeats in Myotonic Dystrophy Type 2 Facilitates Degradation by RNA Quality Control Pathways

Journal of medicinal chemistry, 2021-06, Vol.64 (12), p.8474-8485

2021

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A Small Molecule that Binds an RNA Repeat Expansion Stimulates Its Decay via the Exosome Complex

Cell chemical biology, 2021-01, Vol.28 (1), p.34-45.e6

2021

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Antifungal Imidazole-Decorated Cationic Amphiphiles with Markedly Low Hemolytic Activity

Chemistry : a European journal, 2016-08, Vol.22 (32), p.11148-11151

2016

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Bioinformatic Searching for Optimal RNA Targets of Dimeric Compounds Informs Design of a MicroRNA-27a Inhibitor

ACS chemical biology, 2022-01, Vol.17 (1), p.5-10

2022

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A Toxic RNA Catalyzes the Cellular Synthesis of Its Own Inhibitor, Shunting It to Endogenous Decay Pathways

Cell chemical biology, 2020-02, Vol.27 (2), p.223-231.e4

2020

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Cationic Amphiphiles Induce Macromolecule Denaturation and Organelle Decomposition in Pathogenic Yeast

Angewandte Chemie International Edition, 2018-12, Vol.57 (50), p.16391-16395

International ed. in English, 2018

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Optimization of the Linker Domain in a Dimeric Compound that Degrades an r(CUG) Repeat Expansion in Cells

Journal of medicinal chemistry, 2020-07, Vol.63 (14), p.7827-7839

2020

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Structure-Specific Cleavage of an RNA Repeat Expansion with a Dimeric Small Molecule Is Advantageous over Sequence-Specific Recognition by an Oligonucleotide

ACS chemical biology, 2020-02, Vol.15 (2), p.485-493

2020

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Methods for the study of ribonuclease targeting chimeras (RiboTACs)

Methods in enzymology, 2023, Vol.692, p.249

2023

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Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G 4 C 2 ) repeat expansion in vitro and in vivo ALS models

Science translational medicine, 2021-10, Vol.13 (617), p.eabd5991

2021

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Targeted Degradation of Structured RNAs via Ribonuclease-Targeting Chimeras (RiboTacs)

Targeting the SARS-CoV‑2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders

Di-N-Methylation of Anti-Gram-Positive Aminoglycoside-Derived Membrane Disruptors Improves Antimicrobial Potency and Broadens Spectrum to Gram-Negative Bacteria

Targeting MicroRNAs with Small Molecules

Tuning the Effects of Bacterial Membrane Permeability through Photo‐Isomerization of Antimicrobial Cationic Amphiphiles

Fluorescent Tracking of the Endoplasmic Reticulum in Live Pathogenic Fungal Cells

Real-Time Imaging of the Azole Class of Antifungal Drugs in Live Candida Cells

Bacterial-derived exopolysaccharides enhance antifungal drug tolerance in a cross-kingdom oral biofilm

Localizing Antifungal Drugs to the Correct Organelle Can Markedly Enhance their Efficacy

Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment

Structural insights of lincosamides targeting the ribosome of Staphylococcus aureus

Programming inactive RNA-binding small molecules into bioactive degraders

Progress toward the development of the small molecule equivalent of small interfering RNA

Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles

DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor

A Druglike Small Molecule that Targets r(CCUG) Repeats in Myotonic Dystrophy Type 2 Facilitates Degradation by RNA Quality Control Pathways

A Small Molecule that Binds an RNA Repeat Expansion Stimulates Its Decay via the Exosome Complex

Antifungal Imidazole-Decorated Cationic Amphiphiles with Markedly Low Hemolytic Activity

Bioinformatic Searching for Optimal RNA Targets of Dimeric Compounds Informs Design of a MicroRNA-27a Inhibitor

A Toxic RNA Catalyzes the Cellular Synthesis of Its Own Inhibitor, Shunting It to Endogenous Decay Pathways

Cationic Amphiphiles Induce Macromolecule Denaturation and Organelle Decomposition in Pathogenic Yeast

Optimization of the Linker Domain in a Dimeric Compound that Degrades an r(CUG) Repeat Expansion in Cells

Structure-Specific Cleavage of an RNA Repeat Expansion with a Dimeric Small Molecule Is Advantageous over Sequence-Specific Recognition by an Oligonucleotide

Methods for the study of ribonuclease targeting chimeras (RiboTACs)

Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G 4 C 2 ) repeat expansion in vitro and in vivo ALS models

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