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Role of Basic Science in the Development of New Medicines: Examples from the Eicosanoid Field

The Journal of biological chemistry, 2012-03, Vol.287 (13), p.10070-10080

Samuelsson, Bengt

2012

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Membrane prostaglandin E synthase-1: a novel therapeutic target

Pharmacological reviews, 2007-09, Vol.59 (3), p.207

2007

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Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis

Biochemical and biophysical research communications, 2010-05, Vol.396 (1), p.105-110

2010

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GM‐CSF– and M‐CSF–primed macrophages present similar resolving but distinct inflammatory lipid mediator signatures

The FASEB journal, 2017-10, Vol.31 (10), p.4370-4381

2017

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Modulation of the 5-Lipoxygenase Pathway by Chalcogen-Containing Inhibitors of Leukotriene A4 Hydrolase

International journal of molecular sciences, 2023-04, Vol.24 (8), p.7539

2023

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Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4

Journal of lipid research, 2016-09, Vol.57 (9), p.1659-1669

2016

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Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis

Proceedings of the National Academy of Sciences - PNAS, 2014-08, Vol.111 (31), p.11371-11376

2014

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ERK-mediated regulation of leukotriene biosynthesis by androgens: A molecular basis for gender differences in inflammation and asthma

Proceedings of the National Academy of Sciences - PNAS, 2008-12, Vol.105 (50), p.19881-19886

2008

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The IRE1α Inhibitor KIRA6 Blocks Leukotriene Biosynthesis in Human Phagocytes

Frontiers in pharmacology, 2022-03, Vol.13, p.806240-806240

2022

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Pillars Article: Leukotriene C: A Slow-Reacting Substance from Murine Mastocytoma Cells. Proc. Natl. Acad. Sci. USA. 1979. 76: 4275-4279

The Journal of immunology (1950), 2018-03, Vol.200 (5), p.1538-1542

2018

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Cysteinyl leukotriene receptor 1 antagonism prevents experimental abdominal aortic aneurysm

Proceedings of the National Academy of Sciences - PNAS, 2018-02, Vol.115 (8), p.1907-1912

2018

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Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor

Proceedings of the National Academy of Sciences - PNAS, 2014-03, Vol.111 (11), p.4227-4232

2014

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Identification of Human Prostaglandin E Synthase: A Microsomal, Glutathione-Dependent, Inducible Enzyme, Constituting a Potential Novel Drug Target

Proceedings of the National Academy of Sciences - PNAS, 1999-06, Vol.96 (13), p.7220-7225

1999

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A dynamic Asp–Arg interaction is essential for catalysis in microsomal prostaglandin E₂ synthase

Proceedings of the National Academy of Sciences - PNAS, 2016-01, Vol.113 (4), p.972-977

2016

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Expression of 5-Lipoxygenase and Leukotriene A₄ Hydrolase in Human Atherosclerotic Lesions Correlates with Symptoms of Plaque Instability

Proceedings of the National Academy of Sciences - PNAS, 2006-05, Vol.103 (21), p.8161-8166

2006

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Expanding Expression of the 5-Lipoxygenase Pathway within the Arterial Wall during Human Atherogenesis

Proceedings of the National Academy of Sciences - PNAS, 2003-02, Vol.100 (3), p.1238-1243

2003

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Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells

Proceedings of the National Academy of Sciences - PNAS, 2009-11, Vol.106 (44), p.18757-18762

2009

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Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development

Proceedings of the National Academy of Sciences - PNAS, 2011-12, Vol.108 (51), p.20479-20484

2011

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Increased expression of leukotriene C₄ synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm

Proceedings of the National Academy of Sciences - PNAS, 2010-12, Vol.107 (49), p.21093-21097

2010

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Coactosin-Like Protein Supports 5-Lipoxygenase Enzyme Activity and up-Regulates Leukotriene A₄ Production

Proceedings of the National Academy of Sciences - PNAS, 2006-08, Vol.103 (35), p.13150-13155

2006

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5-Lipoxygenase Is Phosphorylated by p38 Kinase-Dependent MAPKAP Kinases

Proceedings of the National Academy of Sciences - PNAS, 2000-05, Vol.97 (10), p.5261-5266

2000

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Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes

Blood, 2002-02, Vol.99 (3), p.1044-1052

2002

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5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease

Biochimica et biophysica acta, 2015-04, Vol.1851 (4), p.331-339

2015

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Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102

Biochemical journal, 2010-01, Vol.425 (1), p.265-274

2010

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5-Lipoxygenase: mechanisms of regulation1

Journal of lipid research, 2009-04, Vol.50 (Suppl), p.S40-S45

2009

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Role of Basic Science in the Development of New Medicines: Examples from the Eicosanoid Field

Membrane prostaglandin E synthase-1: a novel therapeutic target

Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis

GM‐CSF– and M‐CSF–primed macrophages present similar resolving but distinct inflammatory lipid mediator signatures

Modulation of the 5-Lipoxygenase Pathway by Chalcogen-Containing Inhibitors of Leukotriene A4 Hydrolase

Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4

Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis

ERK-mediated regulation of leukotriene biosynthesis by androgens: A molecular basis for gender differences in inflammation and asthma

The IRE1α Inhibitor KIRA6 Blocks Leukotriene Biosynthesis in Human Phagocytes

Pillars Article: Leukotriene C: A Slow-Reacting Substance from Murine Mastocytoma Cells. Proc. Natl. Acad. Sci. USA. 1979. 76: 4275-4279

Cysteinyl leukotriene receptor 1 antagonism prevents experimental abdominal aortic aneurysm

Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor

Identification of Human Prostaglandin E Synthase: A Microsomal, Glutathione-Dependent, Inducible Enzyme, Constituting a Potential Novel Drug Target

A dynamic Asp–Arg interaction is essential for catalysis in microsomal prostaglandin E₂ synthase

Expression of 5-Lipoxygenase and Leukotriene A₄ Hydrolase in Human Atherosclerotic Lesions Correlates with Symptoms of Plaque Instability

Expanding Expression of the 5-Lipoxygenase Pathway within the Arterial Wall during Human Atherogenesis

Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells

Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development

Increased expression of leukotriene C₄ synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm

Coactosin-Like Protein Supports 5-Lipoxygenase Enzyme Activity and up-Regulates Leukotriene A₄ Production

5-Lipoxygenase Is Phosphorylated by p38 Kinase-Dependent MAPKAP Kinases

Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes

5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease

Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102

5-Lipoxygenase: mechanisms of regulation1

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