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Discovery of Risdiplam, a Selective Survival of Motor Neuron‑2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)

Journal of medicinal chemistry, 2018-08, Vol.61 (15), p.6501-6517

2018

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Coexistence of passive and carrier-mediated processes in drug transport

Nature reviews. Drug discovery, 2010-08, Vol.9 (8), p.597-614

2010

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Fluorine in Medicinal Chemistry

Chembiochem : a European journal of chemical biology, 2004-05, Vol.5 (5), p.637-643

2004

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PAMPA—critical factors for better predictions of absorption

Journal of pharmaceutical sciences, 2007-11, Vol.96 (11), p.2893-2909

2007

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Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities

ChemMedChem, 2007-08, Vol.2 (8), p.1100-1115

2007

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Extending pKa prediction accuracy: High-throughput pKa measurements to understand pKa modulation of new chemical series

European journal of medicinal chemistry, 2010-09, Vol.45 (9), p.4270-4279

2010

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Safety screening in early drug discovery: An optimized assay panel

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106609-106609, Article 106609

2019

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Remote Modulation of Amine Basicity by a Phenylsulfone and a Phenylthio Group

ChemMedChem, 2007-03, Vol.2 (3), p.285-287

2007

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Can we discover pharmacological promiscuity early in the drug discovery process?

Drug discovery today, 2012-04, Vol.17 (7-8), p.325-335

2012

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Abstract 2270: RG7769 (PD1-TIM3), a novel heterodimeric avidity-driven T cell specific PD-1/TIM-3 bispecific antibody lacking Fc-mediated effector functions for dual checkpoint inhibition to reactivate dysfunctional T cells

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.2270-2270

2020

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Solubility-excipient classification gradient maps

Pharmaceutical research, 2007-03, Vol.24 (3), p.530-545

2007

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Novel Triazolopyrimidine-Derived Cannabinoid Receptor 2 Agonists as Potential Treatment for Inflammatory Kidney Diseases

ChemMedChem, 2016-01, Vol.11 (2), p.179-189

2016

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In silico prediction of brain and CSF permeation of small molecules using PLS regression models

European journal of medicinal chemistry, 2008-08, Vol.43 (8), p.1581-1592

2008

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Absorption-excipient-pH classification gradient maps: Sparingly soluble drugs and the pH partition hypothesis

European journal of pharmaceutical sciences, 2008, Vol.33 (1), p.29-41

2008

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PAMPA-excipient classification gradient map

Pharmaceutical research, 2006-11, Vol.23 (11), p.2525-2535

2006

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Inside Cover: Novel Triazolopyrimidine-Derived Cannabinoid Receptor 2 Agonists as Potential Treatment for Inflammatory Kidney Diseases (ChemMedChem 2/2016)

ChemMedChem, 2016-01, Vol.11 (2), p.147-147

2016

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Benzodioxoles: Novel Cannabinoid-1 Receptor Inverse Agonists for the Treatment of Obesity

Journal of medicinal chemistry, 2008-04, Vol.51 (7), p.2115-2127

2008

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Is PAMPA a useful tool for discovery?

Journal of pharmaceutical sciences, 2007-11, Vol.96 (11), p.2886-2892

2007

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Extending p K a prediction accuracy: High-throughput p K a measurements to understand p K a modulation of new chemical series

European journal of medicinal chemistry, 2010, Vol.45 (9), p.4270-4279

2010

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Benzoxazole piperidines as selective and potent somatostatin receptor subtype 5 antagonists

Bioorganic & medicinal chemistry letters, 2009-11, Vol.19 (21), p.6106-6113

2009

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Comparison of a 3D-model of the classical [alpha]-scorpion toxin V from Leiurus quinquestriatus quinquestriatus with other scorpion toxins

Journal of computer-aided molecular design, 2004-02, Vol.18 (2), p.119-133

2004

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Comparison of a 3D-model of the classical alpha-scorpion toxin V from Leiurus quinquestriatus quinquestriatus with other scorpion toxins

Journal of computer-aided molecular design, 2004-02, Vol.18 (2), p.119-133

2004

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Roboter in der Therapie: Vom Demonstrationsobjekt zum Psychotherapeuten

Soziale Roboter, 2021, p.417-440

2021

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Discovery of Risdiplam, a Selective Survival of Motor Neuron‑2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)

Coexistence of passive and carrier-mediated processes in drug transport

Fluorine in Medicinal Chemistry

PAMPA—critical factors for better predictions of absorption

Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities

Extending pKa prediction accuracy: High-throughput pKa measurements to understand pKa modulation of new chemical series

Safety screening in early drug discovery: An optimized assay panel

Remote Modulation of Amine Basicity by a Phenylsulfone and a Phenylthio Group

Can we discover pharmacological promiscuity early in the drug discovery process?

Abstract 2270: RG7769 (PD1-TIM3), a novel heterodimeric avidity-driven T cell specific PD-1/TIM-3 bispecific antibody lacking Fc-mediated effector functions for dual checkpoint inhibition to reactivate dysfunctional T cells

Solubility-excipient classification gradient maps

Novel Triazolopyrimidine-Derived Cannabinoid Receptor 2 Agonists as Potential Treatment for Inflammatory Kidney Diseases

In silico prediction of brain and CSF permeation of small molecules using PLS regression models

Absorption-excipient-pH classification gradient maps: Sparingly soluble drugs and the pH partition hypothesis

PAMPA-excipient classification gradient map

Inside Cover: Novel Triazolopyrimidine-Derived Cannabinoid Receptor 2 Agonists as Potential Treatment for Inflammatory Kidney Diseases (ChemMedChem 2/2016)

Benzodioxoles: Novel Cannabinoid-1 Receptor Inverse Agonists for the Treatment of Obesity

Is PAMPA a useful tool for discovery?

Extending p K a prediction accuracy: High-throughput p K a measurements to understand p K a modulation of new chemical series

Benzoxazole piperidines as selective and potent somatostatin receptor subtype 5 antagonists

Comparison of a 3D-model of the classical [alpha]-scorpion toxin V from Leiurus quinquestriatus quinquestriatus with other scorpion toxins

Comparison of a 3D-model of the classical alpha-scorpion toxin V from Leiurus quinquestriatus quinquestriatus with other scorpion toxins

Roboter in der Therapie: Vom Demonstrationsobjekt zum Psychotherapeuten

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