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Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction

Nature communications, 2019-03, Vol.10 (1), p.1402-12, Article 1402

2019

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Global Impairment of the Ubiquitin-Proteasome System by Nuclear or Cytoplasmic Protein Aggregates Precedes Inclusion Body Formation

Molecular cell, 2005-02, Vol.17 (3), p.351-365

2005

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Impairment of the Ubiquitin-Proteasome System by Protein Aggregation

Science (American Association for the Advancement of Science), 2001-05, Vol.292 (5521), p.1552-1555

2001

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Treatment-Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924

Cancer cell, 2012-03, Vol.21 (3), p.388-401

2012

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Intersecting pathways to neurodegeneration in Parkinson's disease: Effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin–proteasome system

Neurobiology of disease, 2006-05, Vol.22 (2), p.404-420

2006

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A Rhodopsin Mutant Linked to Autosomal Dominant Retinitis Pigmentosa Is Prone to Aggregate and Interacts with the Ubiquitin Proteasome System

The Journal of biological chemistry, 2002-09, Vol.277 (37), p.34150-34160

2002

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Characterization of the loss of SUMO pathway function on cancer cells and tumor proliferation

PloS one, 2015-04, Vol.10 (4), p.e0123882-e0123882

2015

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Mechanistic Study of Uba5 Enzyme and the Ufm1 Conjugation Pathway

The Journal of biological chemistry, 2014-08, Vol.289 (33), p.22648-22658

2014

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Mechanistic Studies of Substrate-assisted Inhibition of Ubiquitin-activating Enzyme by Adenosine Sulfamate Analogues

The Journal of biological chemistry, 2011-11, Vol.286 (47), p.40867-40877

2011

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Formation of Morphologically Similar Globular Aggregates from Diverse Aggregation-Prone Proteins in Mammalian Cells

Proceedings of the National Academy of Sciences - PNAS, 2005-08, Vol.102 (31), p.10887-10892

2005

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Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform

Communications biology, 2021-07, Vol.4 (1), p.834-834, Article 834

2021

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Specificity in Intracellular Protein Aggregation and Inclusion Body Formation

Proceedings of the National Academy of Sciences - PNAS, 2001-11, Vol.98 (23), p.13060-13065

2001

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Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor

Nature chemical biology, 2017-11, Vol.13 (11), p.1164-1171

2017

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Highly Potent BTK Degradation Induced By NRX0492 As a Therapeutic Strategy for CLL

Blood, 2019-11, Vol.134 (Supplement_1), p.174-174

2019

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Abstract 3305: Golcadomide (CC-99282) is a novel CELMoD® agent with antiproliferative activity and combinatorial potential in disease models of chronic lymphocytic leukemia

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.3305-3305

2024

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Targeted Protein Degradation of BTK As a Unique Therapeutic Approach for B Cell Malignancies

Blood, 2019-11, Vol.134 (Supplement_1), p.3805-3805

2019

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Abstract 2696: Genetic and pharmacologic evaluation of the ubiquitin ligase CBL-B as a small-molecule, tumor immunotherapy target

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.2696-2696

2019

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Abstract A164: The small molecule UAE inhibitor TAK-243 (MLN7243) prevents DNA damage repair and reduces cell viability/tumor growth when combined with radiation, carboplatin and docetaxel

Molecular cancer therapeutics, 2015-12, Vol.14 (12_Supplement_2), p.A164-A164

2015

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Abstract LB-371: Evaluating the protein SUMOylation pathway as a potential cancer therapeutic target using inducible RNA interference

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.LB-371-LB-371

2011

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Abstract 3719: TAK-243, a small molecule inhibitor of the ubiquitin activating enzyme (UAE), disrupts DNA damage repair and sensitizes tumor cells and xenografts to ionizing radiation

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.3719-3719

2016

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Abstract 4153: Arrayed microinjection of a ubiquitin activating enzyme inhibitor induces PD biomarker effects predictive of in vivo tumor responses to systemic drug delivery

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.4153-4153

2013

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Redundant Control of the Caenorhabditis elegans Sperm/Oocyte Switch by PUF-8 and FBF-1, Two Distinct PUF RNA-Binding Proteins

Proceedings of the National Academy of Sciences - PNAS, 2005-08, Vol.102 (31), p.10893-10897

2005

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Abstract B196: Evaluation of the ubiquitin activating enzyme ( UBA1 ) as a therapeutic target via inducible RNA interference in human tumor xenografts

Molecular cancer therapeutics, 2011-11, Vol.10 (11_Supplement), p.B196-B196

2011

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Treatment Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 in Pre-Clinical AML and DLBCL Models

Blood, 2011-11, Vol.118 (21), p.1413-1413

2011

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Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction

Global Impairment of the Ubiquitin-Proteasome System by Nuclear or Cytoplasmic Protein Aggregates Precedes Inclusion Body Formation

Impairment of the Ubiquitin-Proteasome System by Protein Aggregation

Treatment-Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924

Intersecting pathways to neurodegeneration in Parkinson's disease: Effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin–proteasome system

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

A Rhodopsin Mutant Linked to Autosomal Dominant Retinitis Pigmentosa Is Prone to Aggregate and Interacts with the Ubiquitin Proteasome System

Characterization of the loss of SUMO pathway function on cancer cells and tumor proliferation

Mechanistic Study of Uba5 Enzyme and the Ufm1 Conjugation Pathway

Mechanistic Studies of Substrate-assisted Inhibition of Ubiquitin-activating Enzyme by Adenosine Sulfamate Analogues

Formation of Morphologically Similar Globular Aggregates from Diverse Aggregation-Prone Proteins in Mammalian Cells

Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform

Specificity in Intracellular Protein Aggregation and Inclusion Body Formation

Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor

Highly Potent BTK Degradation Induced By NRX0492 As a Therapeutic Strategy for CLL

Abstract 3305: Golcadomide (CC-99282) is a novel CELMoD® agent with antiproliferative activity and combinatorial potential in disease models of chronic lymphocytic leukemia

Targeted Protein Degradation of BTK As a Unique Therapeutic Approach for B Cell Malignancies

Abstract 2696: Genetic and pharmacologic evaluation of the ubiquitin ligase CBL-B as a small-molecule, tumor immunotherapy target

Abstract A164: The small molecule UAE inhibitor TAK-243 (MLN7243) prevents DNA damage repair and reduces cell viability/tumor growth when combined with radiation, carboplatin and docetaxel

Abstract LB-371: Evaluating the protein SUMOylation pathway as a potential cancer therapeutic target using inducible RNA interference

Abstract 3719: TAK-243, a small molecule inhibitor of the ubiquitin activating enzyme (UAE), disrupts DNA damage repair and sensitizes tumor cells and xenografts to ionizing radiation

Abstract 4153: Arrayed microinjection of a ubiquitin activating enzyme inhibitor induces PD biomarker effects predictive of in vivo tumor responses to systemic drug delivery

Redundant Control of the Caenorhabditis elegans Sperm/Oocyte Switch by PUF-8 and FBF-1, Two Distinct PUF RNA-Binding Proteins

Abstract B196: Evaluation of the ubiquitin activating enzyme ( UBA1 ) as a therapeutic target via inducible RNA interference in human tumor xenografts

Treatment Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 in Pre-Clinical AML and DLBCL Models

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