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Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach

Environmental and molecular mutagenesis, 2016-04, Vol.57 (3), p.171-189

2016

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Lack of hydroxyurea‐associated mutagenesis in pediatric sickle cell disease patients

Environmental and molecular mutagenesis, 2023-03, Vol.64 (3), p.167-175

2023

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Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose

Environmental and molecular mutagenesis, 2023-02, Vol.64 (2), p.105-122

2023

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Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds

Toxicological sciences, 2012-12, Vol.130 (2), p.328-348

2012

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Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay

Environmental and molecular mutagenesis, 2017-04, Vol.58 (3), p.146-161

2017

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In vivo mutation assay based on the endogenous Pig-a locus

Environmental and molecular mutagenesis, 2008-05, Vol.49 (4), p.256-264

2008

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EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress

Blood, 2012-09, Vol.120 (12), p.2501-2511

2012

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In vitro micronucleus assay scored by flow cytometry provides a comprehensive evaluation of cytogenetic damage and cytotoxicity

Mutation research, 2007-06, Vol.630 (1), p.78-91

2007

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Pig-a Mutation: Kinetics in Rat Erythrocytes Following Exposure to Five Prototypical Mutagens

Toxicological sciences, 2010-03, Vol.114 (1), p.59-70

2010

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Comparison of male versus female responses in the Pig-a mutation assay

Mutagenesis, 2015-05, Vol.30 (3), p.349-357

2015

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Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone

Environmental and molecular mutagenesis, 2014-05, Vol.55 (4), p.299-308

2014

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Induction of Pig-a mutant erythrocytes in male and female rats exposed to 1,3-propane sultone, ethyl carbamate, or thiotepa

Mutation research. Genetic toxicology and environmental mutagenesis, 2015-04, Vol.782, p.24-29

2015

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Miniaturized flow cytometry-based CHO-K1 micronucleus assay discriminates aneugenic and clastogenic modes of action

Environmental and molecular mutagenesis, 2011-05, Vol.52 (4), p.280-286

2011

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Diethylnitrosamine genotoxicity evaluated in sprague dawley rats using Pig-a mutation and reticulocyte micronucleus assays

Environmental and molecular mutagenesis, 2014-06, Vol.55 (5), p.400-406

2014

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Sublethal radiation injury uncovers a functional transition during erythroid maturation

Experimental hematology, 2011-04, Vol.39 (4), p.434-445

2011

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Interlaboratory evaluation of a flow cytometric, high content in vitro micronucleus assay

Mutation research, 2008-02, Vol.650 (2), p.181-195

2008

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Investigating the Generalizability of the MultiFlow ® DNA Damage Assay and Several Companion Machine Learning Models With a Set of 103 Diverse Test Chemicals

Toxicological sciences, 2018-03, Vol.162 (1), p.146-166

2018

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Aneugen Molecular Mechanism Assay: Proof-of-Concept With 27 Reference Chemicals

Toxicological sciences, 2019-08, Vol.170 (2), p.382-393

2019

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Kinetics of γH2AX and phospho-histone H3 following pulse treatment of TK6 cells provides insights into clastogenic activity

Mutagenesis, 2021-07, Vol.36 (3), p.255-264

2021

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Visualization strategies to aid interpretation of high‐dimensional genotoxicity data

Environmental and molecular mutagenesis, 2024-06, Vol.65 (5), p.156-178

2024

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In vivo flow cytometric Pig-a and micronucleus assays: Highly sensitive discrimination of the carcinogen/noncarcinogen pair benzo(a)pyrene and pyrene using acute and repeated-dose designs

Environmental and molecular mutagenesis, 2012-07, Vol.53 (6), p.420-428

2012

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In vitro human cell‐based aneugen molecular mechanism assay

Environmental and molecular mutagenesis, 2022-03, Vol.63 (3), p.151-161

2022

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Dioxin Causes Ventral Prostate Agenesis by Disrupting Dorsoventral Patterning in Developing Mouse Prostate

Toxicological sciences, 2008-12, Vol.106 (2), p.488-496

2008

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3Rs friendly study designs facilitate rat liver and blood micronucleus assays and Pig‐a gene mutation assessments: Proof‐of‐concept with 13 reference chemicals

Environmental and molecular mutagenesis, 2019-10, Vol.60 (8), p.704-739

2019

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Erythrocyte-Based Pig-a Gene Mutation Assay

Methods in molecular biology (Clifton, N.J.), 2019, Vol.2031, p.29

2019

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Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach

Lack of hydroxyurea‐associated mutagenesis in pediatric sickle cell disease patients

Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose

Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds

Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay

In vivo mutation assay based on the endogenous Pig-a locus

EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress

In vitro micronucleus assay scored by flow cytometry provides a comprehensive evaluation of cytogenetic damage and cytotoxicity

Pig-a Mutation: Kinetics in Rat Erythrocytes Following Exposure to Five Prototypical Mutagens

Comparison of male versus female responses in the Pig-a mutation assay

Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone

Induction of Pig-a mutant erythrocytes in male and female rats exposed to 1,3-propane sultone, ethyl carbamate, or thiotepa

Miniaturized flow cytometry-based CHO-K1 micronucleus assay discriminates aneugenic and clastogenic modes of action

Diethylnitrosamine genotoxicity evaluated in sprague dawley rats using Pig-a mutation and reticulocyte micronucleus assays

Sublethal radiation injury uncovers a functional transition during erythroid maturation

Interlaboratory evaluation of a flow cytometric, high content in vitro micronucleus assay

Investigating the Generalizability of the MultiFlow ® DNA Damage Assay and Several Companion Machine Learning Models With a Set of 103 Diverse Test Chemicals

Aneugen Molecular Mechanism Assay: Proof-of-Concept With 27 Reference Chemicals

Kinetics of γH2AX and phospho-histone H3 following pulse treatment of TK6 cells provides insights into clastogenic activity

Visualization strategies to aid interpretation of high‐dimensional genotoxicity data

In vivo flow cytometric Pig-a and micronucleus assays: Highly sensitive discrimination of the carcinogen/noncarcinogen pair benzo(a)pyrene and pyrene using acute and repeated-dose designs

In vitro human cell‐based aneugen molecular mechanism assay

Dioxin Causes Ventral Prostate Agenesis by Disrupting Dorsoventral Patterning in Developing Mouse Prostate

3Rs friendly study designs facilitate rat liver and blood micronucleus assays and Pig‐a gene mutation assessments: Proof‐of‐concept with 13 reference chemicals

Erythrocyte-Based Pig-a Gene Mutation Assay

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