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Advances in TRP channel drug discovery: from target validation to clinical studies

Nature reviews. Drug discovery, 2022-01, Vol.21 (1), p.41-59

2022

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Maps and legends: the quest for dissociated ligands of the glucocorticoid receptor

Pharmacology & therapeutics (Oxford), 2012-04, Vol.134 (1), p.54-67

2012

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Cough and airway disease: The role of ion channels

Pulmonary pharmacology & therapeutics, 2017-12, Vol.47, p.21-28

2017

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Modulation of the TRPV4 ion channel as a therapeutic target for disease

Pharmacology & therapeutics (Oxford), 2017-09, Vol.177, p.9-22

2017

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Expert opinion on the cough hypersensitivity syndrome in respiratory medicine

The European respiratory journal, 2014-11, Vol.44 (5), p.1132-1148

2014

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Transient receptor potential cation channel, subfamily V, member 4 and airway sensory afferent activation: Role of adenosine triphosphate

Journal of allergy and clinical immunology, 2016-07, Vol.138 (1), p.249-261.e12

2016

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Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium

PLoS pathogens, 2010-11, Vol.6 (11), p.e1001178-e1001178

2010

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Novel airway smooth muscle-mast cell interactions and a role for the TRPV4-ATP axis in non-atopic asthma

The European respiratory journal, 2020-07, Vol.56 (1), p.1901458

2020

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Anti-inflammatory effects of PGE2 in the lung: role of the EP4 receptor subtype

Thorax, 2015-08, Vol.70 (8), p.740-747

2015

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P2X7 receptor and caspase 1 activation are central to airway inflammation observed after exposure to tobacco smoke

PloS one, 2011-09, Vol.6 (9), p.e24097

2011

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DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease

American journal of physiology. Lung cellular and molecular physiology, 2015-11, Vol.309 (10), p.L1124-L1137

2015

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Role of the inflammasome-caspase1/11-IL-1/18 axis in cigarette smoke driven airway inflammation: an insight into the pathogenesis of COPD

PloS one, 2014-11, Vol.9 (11), p.e112829-e112829

2014

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Mechanistic link between diesel exhaust particles and respiratory reflexes

Journal of allergy and clinical immunology, 2018-03, Vol.141 (3), p.1074-1084.e9

2018

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Advances in TRP channel drug discovery: from target validation to clinical studies

Nature reviews. Drug discovery, 2022-01, Vol.21 (1), p.41-59

2022

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TRPA1 Agonists Evoke Coughing in Guinea Pig and Human Volunteers

American journal of respiratory and critical care medicine, 2009-12, Vol.180 (11), p.1042-1047

2009

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Role of transient receptor potential and pannexin channels in cigarette smoke-triggered ATP release in the lung

Thorax, 2014-12, Vol.69 (12), p.1080-1089

2014

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Effect of traffic-related air pollution on cough in adults with polymorphisms in several cough-related genes

Respiratory research, 2022-05, Vol.23 (1), p.113-113, Article 113

2022

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Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids

BMC genomics, 2007-07, Vol.8 (1), p.240-240, Article 240

2007

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Back to the future: re-establishing guinea pig in vivo asthma models

Clinical science (1979), 2020-06, Vol.134 (11), p.1219-1242

2020

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Targeting TRP channels for chronic cough: from bench to bedside

Naunyn-Schmiedeberg's archives of pharmacology, 2015-04, Vol.388 (4), p.401-420

2015

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PI3Kγδ inhibition suppresses key disease features in a rat model of asthma

Respiratory research, 2024-04, Vol.25 (1), p.175-175, Article 175

2024

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Chronic lung diseases: prospects for regeneration and repair

European respiratory review, 2021-03, Vol.30 (159), p.200213

2021

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Tiotropium modulates transient receptor potential V1 (TRPV1) in airway sensory nerves: A beneficial off-target effect?

Journal of allergy and clinical immunology, 2014-03, Vol.133 (3), p.679-687.e9

2014

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Respiratory infections cause the release of extracellular vesicles: implications in exacerbation of asthma/COPD

PloS one, 2014-06, Vol.9 (6), p.e101087

2014

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Targeting fatty acid amide hydrolase as a therapeutic strategy for antitussive therapy

The European respiratory journal, 2017-09, Vol.50 (3), p.1700782-1700782

2017

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Advances in TRP channel drug discovery: from target validation to clinical studies

Maps and legends: the quest for dissociated ligands of the glucocorticoid receptor

Cough and airway disease: The role of ion channels

Modulation of the TRPV4 ion channel as a therapeutic target for disease

Expert opinion on the cough hypersensitivity syndrome in respiratory medicine

Transient receptor potential cation channel, subfamily V, member 4 and airway sensory afferent activation: Role of adenosine triphosphate

Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium

Novel airway smooth muscle-mast cell interactions and a role for the TRPV4-ATP axis in non-atopic asthma

Anti-inflammatory effects of PGE2 in the lung: role of the EP4 receptor subtype

P2X7 receptor and caspase 1 activation are central to airway inflammation observed after exposure to tobacco smoke

DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease

Role of the inflammasome-caspase1/11-IL-1/18 axis in cigarette smoke driven airway inflammation: an insight into the pathogenesis of COPD

Mechanistic link between diesel exhaust particles and respiratory reflexes

Advances in TRP channel drug discovery: from target validation to clinical studies

TRPA1 Agonists Evoke Coughing in Guinea Pig and Human Volunteers

Role of transient receptor potential and pannexin channels in cigarette smoke-triggered ATP release in the lung

Effect of traffic-related air pollution on cough in adults with polymorphisms in several cough-related genes

Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids

Back to the future: re-establishing guinea pig in vivo asthma models

Targeting TRP channels for chronic cough: from bench to bedside

PI3Kγδ inhibition suppresses key disease features in a rat model of asthma

Chronic lung diseases: prospects for regeneration and repair

Tiotropium modulates transient receptor potential V1 (TRPV1) in airway sensory nerves: A beneficial off-target effect?

Respiratory infections cause the release of extracellular vesicles: implications in exacerbation of asthma/COPD

Targeting fatty acid amide hydrolase as a therapeutic strategy for antitussive therapy

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