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The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein

Nature (London), 2002-04, Vol.416 (6881), p.640-644

2002

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Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors

Science (American Association for the Advancement of Science), 2003-12, Vol.302 (5653), p.2126-2130

2003

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A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway

Annual review of cell and developmental biology, 1996-01, Vol.12 (1), p.393-416

1996

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387 Combination of the ERK inhibitor GDC-0994 with the MEK inhibitor cobimetinib significantly enhances anti-tumor activity in KRAS and BRAF mutant tumor models

European journal of cancer (1990), 2014-11, Vol.50, p.124-124

2014

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502 Preclinical Pharmacokinetics and Efficacy Assessment of a Potent and Selective MEK Inhibitor, GDC-0623

European journal of cancer (1990), 2012-11, Vol.48, p.155-155

2012

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378 Differential Targeting of KRAS and BRAF Mutant Tumors Using MEK Inhibitors with Distinct Mechanisms of Action

European journal of cancer (1990), 2012-11, Vol.48, p.115-115

2012

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43 Targeting the PI3K/mTOR Pathway for Sarcoma Treatment: Investigation in Rat Syngeneic Chondrosarcoma Model

European journal of cancer (1990), 2012-11, Vol.48, p.15-15

2012

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Cactus protein degradation mediates Drosophila dorsal-ventral signaling

Genes & development, 1995-04, Vol.9 (7), p.783-793

1995

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The Drosophila dCREB2 Gene Affects the Circadian Clock

Neuron (Cambridge, Mass.), 1999-04, Vol.22 (4), p.777-787

1999

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Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors

The Journal of immunology (1950), 1990-07, Vol.145 (2), p.576-584

1990

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CX-2043, an EpCAM-targeting probody drug conjugate, demonstrates anti-tumor activity with a favorable safety profile in preclinical models

European journal of cancer (1990), 2020-10, Vol.138, p.S15-S15

2020

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A Genome-Wide Analysis of Immune Responses in Drosophila

Proceedings of the National Academy of Sciences - PNAS, 2001-12, Vol.98 (26), p.15119-15124

2001

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A serpin mutant links Toll activation to melanization in the host defence of Drosophila

The EMBO journal, 2002-12, Vol.21 (23), p.6330-6337

2002

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Drosophila p53 Is a Structural and Functional Homolog of the Tumor Suppressor p53

Cell, 2000-03, Vol.101 (1), p.91-101

2000

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Abstract PD4-14: GDC-0077 is a selective PI3Kalpha inhibitor that demonstrates robust efficacy in PIK3CA mutant breast cancer models as a single agent and in combination with standard of care therapies

Cancer research (Chicago, Ill.), 2018-02, Vol.78 (4_Supplement), p.PD4-14-PD4-14

2018

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205 Distinct inhibitory properties of MEK inhibitors on pathway feedback translate into differential potency in BRAF and RAS mutant cancer cells

European journal of cancer supplements, 2010, Vol.8 (7), p.68-68

2010

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142 GDC-0941 PI3K inhibitor activity in preclinical lung cancer models

European journal of cancer supplements, 2010, Vol.8 (7), p.51-51

2010

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343 Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of squamous NSCLC cells

European journal of cancer supplements, 2010, Vol.8 (7), p.109-109

2010

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132 Intermittent dosing of the MEK inhibitor, GDC-0973, and the PI3K inhibitor, GDC-0941, results in prolonged accumulation of Bim and causes strong tumor growth inhibition in vivo

European journal of cancer supplements, 2010, Vol.8 (7), p.48-48

2010

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Regulation of leukocyte adhesion molecule-1 (TQ1, Leu-8) expression and shedding by normal and malignant cells

Leukemia, 1991-04, Vol.5 (4), p.300-308

1991

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Abstract P2-17-01: The PI3K inhibitor GDC-0032 is selectively potent against PIK3CA mutant breast cancer cell lines and tumors

Cancer research (Chicago, Ill.), 2013-12, Vol.73 (24_Supplement), p.P2-P2-17-01

2013

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The Drosophila Immune Defense against Gram-Negative Infection Requires the Death Protein dFADD

Immunity (Cambridge, Mass.), 2002-11, Vol.17 (5), p.575-581

2002

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Abstract P4-15-02: The PI3K inhibitor GDC-0032 enhances the efficacy of standard of care therapeutics in PI3K alpha mutant breast cancer models

Cancer research (Chicago, Ill.), 2013-12, Vol.73 (24_Supplement), p.P4-P4-15-02

2013

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587 POSTER Understanding the role of Raf signaling in B-Raf V600E mutant versus wildtype tumors

European journal of cancer supplements, 2008, Vol.6 (12), p.183-184

2008

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220 POSTER Combination of class I PI3K inhibitor, GDC-0941, with standard of care therapeutics results in enhanced anti-tumor responses in human cancer models in vitro and in vivo

European journal of cancer supplements, 2008, Vol.6 (12), p.69-70

2008

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The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein

Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors

A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway

387 Combination of the ERK inhibitor GDC-0994 with the MEK inhibitor cobimetinib significantly enhances anti-tumor activity in KRAS and BRAF mutant tumor models

502 Preclinical Pharmacokinetics and Efficacy Assessment of a Potent and Selective MEK Inhibitor, GDC-0623

378 Differential Targeting of KRAS and BRAF Mutant Tumors Using MEK Inhibitors with Distinct Mechanisms of Action

43 Targeting the PI3K/mTOR Pathway for Sarcoma Treatment: Investigation in Rat Syngeneic Chondrosarcoma Model

Cactus protein degradation mediates Drosophila dorsal-ventral signaling

The Drosophila dCREB2 Gene Affects the Circadian Clock

Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors

CX-2043, an EpCAM-targeting probody drug conjugate, demonstrates anti-tumor activity with a favorable safety profile in preclinical models

A Genome-Wide Analysis of Immune Responses in Drosophila

A serpin mutant links Toll activation to melanization in the host defence of Drosophila

Drosophila p53 Is a Structural and Functional Homolog of the Tumor Suppressor p53

Abstract PD4-14: GDC-0077 is a selective PI3Kalpha inhibitor that demonstrates robust efficacy in PIK3CA mutant breast cancer models as a single agent and in combination with standard of care therapies

205 Distinct inhibitory properties of MEK inhibitors on pathway feedback translate into differential potency in BRAF and RAS mutant cancer cells

142 GDC-0941 PI3K inhibitor activity in preclinical lung cancer models

343 Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of squamous NSCLC cells

132 Intermittent dosing of the MEK inhibitor, GDC-0973, and the PI3K inhibitor, GDC-0941, results in prolonged accumulation of Bim and causes strong tumor growth inhibition in vivo

Regulation of leukocyte adhesion molecule-1 (TQ1, Leu-8) expression and shedding by normal and malignant cells

Abstract P2-17-01: The PI3K inhibitor GDC-0032 is selectively potent against PIK3CA mutant breast cancer cell lines and tumors

The Drosophila Immune Defense against Gram-Negative Infection Requires the Death Protein dFADD

Abstract P4-15-02: The PI3K inhibitor GDC-0032 enhances the efficacy of standard of care therapeutics in PI3K alpha mutant breast cancer models

587 POSTER Understanding the role of Raf signaling in B-Raf V600E mutant versus wildtype tumors

220 POSTER Combination of class I PI3K inhibitor, GDC-0941, with standard of care therapeutics results in enhanced anti-tumor responses in human cancer models in vitro and in vivo

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