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The MRP family of drug efflux pumps

Oncogene, 2003-10, Vol.22 (47), p.7537-7552

2003

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Linsitinib (OSI-906) for the Treatment of Adult and Pediatric Wild-Type Gastrointestinal Stromal Tumors, a SARC Phase II Study

Clinical cancer research, 2020-04, Vol.26 (8), p.1837-1845

2020

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organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis

Proceedings of the National Academy of Sciences - PNAS, 2008-03, Vol.105 (10), p.3891-3896

2008

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Succinate dehydrogenase deficiency in a PDGFRA mutated GIST

BMC cancer, 2017-08, Vol.17 (1), p.512-512, Article 512

2017

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Combination of Imatinib Mesylate and AKT Inhibitor Provides Synergistic Effects in Preclinical Study of Gastrointestinal Stromal Tumor

Clinical cancer research, 2017-01, Vol.23 (1), p.171-180

2017

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Succinate dehydrogenase deficiency in pediatric and adult gastrointestinal stromal tumors

Frontiers in oncology, 2013-01, Vol.3, p.117-117

2013

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MRP8, ATP-binding Cassette C11 (ABCC11), Is a Cyclic Nucleotide Efflux Pump and a Resistance Factor for Fluoropyrimidines 2′,3′-Dideoxycytidine and 9′-(2′-Phosphonylmethoxyethyl)adenine

The Journal of biological chemistry, 2003-08, Vol.278 (32), p.29509-29514

2003

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Overexpression of insulin-like growth factor 1 receptor and frequent mutational inactivation of SDHA in wild-type SDHB-negative gastrointestinal stromal tumors

Genes chromosomes & cancer, 2013-02, Vol.52 (2), p.214-224

2013

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Somatic loss of function mutations in neurofibromin 1 and MYC associated factor X genes identified by exome-wide sequencing in a wild-type GIST case

BMC cancer, 2015-11, Vol.15 (883), p.887-887, Article 887

2015

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Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): Resistance to docetaxel

Cancer research (Chicago, Ill.), 2004-07, Vol.64 (14), p.4927-4930

2004

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ABCC10, ABCC11, and ABCC12

Pflügers Archiv, 2007-02, Vol.453 (5), p.675-684

2007

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Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6)

Cancer research (Chicago, Ill.), 2002-11, Vol.62 (21), p.6172-6177

2002

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Analysis of the In Vivo Functions of Mrp3

Molecular pharmacology, 2005-07, Vol.68 (1), p.160-168

2005

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Transport of methotrexate, methotrexate polyglutamates, and 17β-estradiol 17-(β-D-glucuronide) by ABCG2: Effects of acquired mutations at R482 on methotrexate transport

Cancer research (Chicago, Ill.), 2003-07, Vol.63 (14), p.4048-4054

2003

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Characterization of the Transport Properties of Human Multidrug Resistance Protein 7 (MRP7, ABCC10)

Molecular pharmacology, 2003-02, Vol.63 (2), p.351-358

2003

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Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11)

Molecular pharmacology, 2005-02, Vol.67 (2), p.545-557

2005

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Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice

Cancer and metastasis reviews, 2007-03, Vol.26 (1), p.5-14

2007

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Contribution of Abcc10 (Mrp7) to In Vivo Paclitaxel Resistance as Assessed in Abcc10-/- Mice

Cancer research (Chicago, Ill.), 2011-05, Vol.71 (10), p.3649-3657

2011

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Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: Effect of polyglutamylation on MTX transport

Cancer research (Chicago, Ill.), 2001-10, Vol.61 (19), p.7225-7232

2001

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Gene expression signatures and response to imatinib mesylate in gastrointestinal stromal tumor

Molecular cancer therapeutics, 2009-08, Vol.8 (8), p.2172-2182

2009

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Identification of Wee1 as a target in combination with avapritinib for gastrointestinal stromal tumor treatment

JCI insight, 2021-01, Vol.6 (2)

2021

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Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3-/- and Abcc4-/- mice

The Journal of pharmacology and experimental therapeutics, 2006-12, Vol.319 (3), p.1485

2006

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Determination of methotrexate and its major metabolite 7-hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometry

Journal of pharmaceutical and biomedical analysis, 2007-04, Vol.43 (5), p.1789-1795

2007

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Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse livers

Drug metabolism and disposition, 2008-05, Vol.36 (5), p.911

2008

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Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily

Cancer letters, 2001-01, Vol.162 (2), p.181-191

2001

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The MRP family of drug efflux pumps

Linsitinib (OSI-906) for the Treatment of Adult and Pediatric Wild-Type Gastrointestinal Stromal Tumors, a SARC Phase II Study

organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis

Succinate dehydrogenase deficiency in a PDGFRA mutated GIST

Combination of Imatinib Mesylate and AKT Inhibitor Provides Synergistic Effects in Preclinical Study of Gastrointestinal Stromal Tumor

Succinate dehydrogenase deficiency in pediatric and adult gastrointestinal stromal tumors

MRP8, ATP-binding Cassette C11 (ABCC11), Is a Cyclic Nucleotide Efflux Pump and a Resistance Factor for Fluoropyrimidines 2′,3′-Dideoxycytidine and 9′-(2′-Phosphonylmethoxyethyl)adenine

Overexpression of insulin-like growth factor 1 receptor and frequent mutational inactivation of SDHA in wild-type SDHB-negative gastrointestinal stromal tumors

Somatic loss of function mutations in neurofibromin 1 and MYC associated factor X genes identified by exome-wide sequencing in a wild-type GIST case

Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): Resistance to docetaxel

ABCC10, ABCC11, and ABCC12

Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6)

Analysis of the In Vivo Functions of Mrp3

Transport of methotrexate, methotrexate polyglutamates, and 17β-estradiol 17-(β-D-glucuronide) by ABCG2: Effects of acquired mutations at R482 on methotrexate transport

Characterization of the Transport Properties of Human Multidrug Resistance Protein 7 (MRP7, ABCC10)

Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11)

Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice

Contribution of Abcc10 (Mrp7) to In Vivo Paclitaxel Resistance as Assessed in Abcc10-/- Mice

Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: Effect of polyglutamylation on MTX transport

Gene expression signatures and response to imatinib mesylate in gastrointestinal stromal tumor

Identification of Wee1 as a target in combination with avapritinib for gastrointestinal stromal tumor treatment

Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3-/- and Abcc4-/- mice

Determination of methotrexate and its major metabolite 7-hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometry

Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse livers

Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily

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