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Stable Suppression of the R2 Subunit of Ribonucleotide Reductase by R2-targeted Short Interference RNA Sensitizes p53(–/–) HCT-116 Colon Cancer Cells to DNA-damaging Agents and Ribonucleotide Reductase Inhibitors

The Journal of biological chemistry, 2004-06, Vol.279 (26), p.27030-27038

2004

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Reduced level of ribonucleotide reductase R2 subunits increases dependence on homologous recombination repair of cisplatin-induced DNA damage

Molecular pharmacology, 2011-12, Vol.80 (6), p.1000-1012

2011

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Tumor-targeted Salmonella expressing cytosine deaminase as an anticancer agent

Human gene therapy, 2002-07, Vol.13 (10), p.1225-1233

2002

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Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress

Biochemical pharmacology, 2007-03, Vol.73 (6), p.760-772

2007

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Nuclear Overexpression of NAD(P)H:Quinone Oxidoreductase 1 in Chinese Hamster Ovary Cells Increases the Cytotoxicity of Mitomycin C under Aerobic and Hypoxic Conditions

The Journal of biological chemistry, 2004-07, Vol.279 (30), p.31606-31612

2004

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Nuclear Localization of NADPH:Cytochrome c (P450) Reductase Enhances the Cytotoxicity of Mitomycin C to Chinese Hamster Ovary Cells

Molecular pharmacology, 2005-02, Vol.67 (2), p.417-423

2005

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Differential Toxicity of Mitomycin C and Porfiromycin to Aerobic and Hypoxic Chinese Hamster Ovary Cells Overexpressing Human NADPH:Cytochrome c (P-450) Reductase

Proceedings of the National Academy of Sciences - PNAS, 1996-01, Vol.93 (1), p.456-460

1996

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Structure of Adduct X, the Last Unknown of the Six Major DNA Adducts of Mitomycin C Formed in EMT6 Mouse Mammary Tumor Cells

Chemical research in toxicology, 2000-06, Vol.13 (6), p.479-488

2000

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Reversal of mitomycin C resistance by overexpression of bioreductive enzymes in Chinese hamster ovary cells

Cancer research (Chicago, Ill.), 2001-11, Vol.61 (21), p.7770-7776

2001

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Mitomycin Resistance in Mammalian Cells Expressing the Bacterial Mitomycin C Resistance Protein MCRA

Proceedings of the National Academy of Sciences - PNAS, 1999-08, Vol.96 (18), p.10489-10494

1999

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Hypoxia-Selective Nitrobenzyloxycarbonyl Derivatives of 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)hydrazines

Journal of medicinal chemistry, 1999-03, Vol.42 (5), p.941-946

1999

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Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells : Cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol

Biochemical pharmacology, 2001-06, Vol.61 (12), p.1517-1529

2001

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Inhibition of DNA Cross-linking by Mitomycin C by Peroxidase-mediated Oxidation of Mitomycin C Hydroquinone

The Journal of biological chemistry, 2001-09, Vol.276 (37), p.34445-34452

2001

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Reduced Level of Ribonucleotide Reductase R2 Subunits Increases Dependence on Homologous Recombination Repair of Cisplatin-Induced DNA DamageS

Molecular pharmacology, 2011-12, Vol.80 (6), p.1000-1012

2011

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Tumor-targeted Salmonella expressing cytosine deaminase as an anticancer agent

Human gene therapy, 2002-07, Vol.13 (10), p.1225-1233

2002

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Ribosomal frameshifting in the yeast retrotransposon Ty: tRNAs induce slippage on a 7 nucleotide minimal site

Cell, 1990-07, Vol.62 (2), p.339-352

1990

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Mitomycin C: a prototype bioreductive agent

Oncology research, 1994, Vol.6 (10-11), p.501

1994

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The intracellular location of NADH:cytochrome b5 reductase modulates the cytotoxicity of the mitomycins to Chinese hamster ovary cells

The Journal of biological chemistry, 1998-04, Vol.273 (15), p.8875

1998

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Bioactivation of mitomycin antibiotics by aerobic and hypoxic Chinese hamster ovary cells overexpressing DT-diaphorase

Biochemical pharmacology, 1996-06, Vol.51 (12), p.1669-1678

1996

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Formation of a major DNA adduct of the mitomycin metabolite 2,7-diaminomitosene in EMT6 mouse mammary tumor cells treated with mitomycin C

Oncology research, 1998, Vol.10 (10), p.509

1998

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Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol 4 4Abbreviations: MC, mitomycin C; DIC, dicumarol; 2,7-DAM, 2,7-diaminomitosene; and XDH, xanthine dehydrogenase

Biochemical pharmacology, 2001-06, Vol.61 (12), p.1517-1529

2001

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Tumour-Selective Salmonella-Based Cancer Therapy

Biotechnology & genetic engineering reviews, 2001, Vol.18 (1), p.219-233

2001

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The Intracellular Location of NADH:Cytochromeb5 Reductase Modulates the Cytotoxicity of the Mitomycins to Chinese Hamster Ovary Cells

The Journal of biological chemistry, 1998-04, Vol.273 (15), p.8875-8881

1998

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The Intracellular Location of NADH:Cytochromeb 5 Reductase Modulates the Cytotoxicity of the Mitomycins to Chinese Hamster Ovary Cells

The Journal of biological chemistry, 1998-04, Vol.273 (15), p.8875

1998

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Ribosomal frameshifting in yeast Ty elements

Belcourt, Michael Fred

1990

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Stable Suppression of the R2 Subunit of Ribonucleotide Reductase by R2-targeted Short Interference RNA Sensitizes p53(–/–) HCT-116 Colon Cancer Cells to DNA-damaging Agents and Ribonucleotide Reductase Inhibitors

Reduced level of ribonucleotide reductase R2 subunits increases dependence on homologous recombination repair of cisplatin-induced DNA damage

Tumor-targeted Salmonella expressing cytosine deaminase as an anticancer agent

Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress

Nuclear Overexpression of NAD(P)H:Quinone Oxidoreductase 1 in Chinese Hamster Ovary Cells Increases the Cytotoxicity of Mitomycin C under Aerobic and Hypoxic Conditions

Nuclear Localization of NADPH:Cytochrome c (P450) Reductase Enhances the Cytotoxicity of Mitomycin C to Chinese Hamster Ovary Cells

Differential Toxicity of Mitomycin C and Porfiromycin to Aerobic and Hypoxic Chinese Hamster Ovary Cells Overexpressing Human NADPH:Cytochrome c (P-450) Reductase

Structure of Adduct X, the Last Unknown of the Six Major DNA Adducts of Mitomycin C Formed in EMT6 Mouse Mammary Tumor Cells

Reversal of mitomycin C resistance by overexpression of bioreductive enzymes in Chinese hamster ovary cells

Mitomycin Resistance in Mammalian Cells Expressing the Bacterial Mitomycin C Resistance Protein MCRA

Hypoxia-Selective Nitrobenzyloxycarbonyl Derivatives of 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)hydrazines

Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells : Cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol

Inhibition of DNA Cross-linking by Mitomycin C by Peroxidase-mediated Oxidation of Mitomycin C Hydroquinone

Reduced Level of Ribonucleotide Reductase R2 Subunits Increases Dependence on Homologous Recombination Repair of Cisplatin-Induced DNA DamageS

Tumor-targeted Salmonella expressing cytosine deaminase as an anticancer agent

Ribosomal frameshifting in the yeast retrotransposon Ty: tRNAs induce slippage on a 7 nucleotide minimal site

Mitomycin C: a prototype bioreductive agent

The intracellular location of NADH:cytochrome b5 reductase modulates the cytotoxicity of the mitomycins to Chinese hamster ovary cells

Bioactivation of mitomycin antibiotics by aerobic and hypoxic Chinese hamster ovary cells overexpressing DT-diaphorase

Formation of a major DNA adduct of the mitomycin metabolite 2,7-diaminomitosene in EMT6 mouse mammary tumor cells treated with mitomycin C

Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol 4 4Abbreviations: MC, mitomycin C; DIC, dicumarol; 2,7-DAM, 2,7-diaminomitosene; and XDH, xanthine dehydrogenase

Tumour-Selective Salmonella-Based Cancer Therapy

The Intracellular Location of NADH:Cytochromeb5 Reductase Modulates the Cytotoxicity of the Mitomycins to Chinese Hamster Ovary Cells

The Intracellular Location of NADH:Cytochromeb 5 Reductase Modulates the Cytotoxicity of the Mitomycins to Chinese Hamster Ovary Cells

Ribosomal frameshifting in yeast Ty elements

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