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Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints

Bioorganic & medicinal chemistry letters, 2005-12, Vol.15 (23), p.5114-5119

2005

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Spirocyclic Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-3-hydroxy-4-(spiro[chromene-2,4′-piperidine]-4-yl) Benzamide (ADL5747)

Journal of medicinal chemistry, 2009-09, Vol.52 (18), p.5685-5702

2009

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Potent, Orally Bioavailable Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-4-(5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl)benzamide (ADL5859)

Journal of medicinal chemistry, 2008-10, Vol.51 (19), p.5893-5896

2008

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Synthesis and Pharmacological Evaluation of Novel Octahydro-1H-pyrido[1,2-a]pyrazine as μ-Opioid Receptor Antagonists

Journal of medicinal chemistry, 2006-12, Vol.49 (25), p.7290-7306

2006

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Novel malonamide derivatives as potent κ opioid receptor agonists

Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (7), p.1951-1955

2007

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Elucidation of the Bioactive Conformation of the N-Substituted trans-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine Class of μ-Opioid Receptor Antagonists

Journal of medicinal chemistry, 2006-12, Vol.49 (25), p.7278-7289

2006

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Synthesis and Pharmacological Evaluation of Novel Octahydro-1 H -pyrido[1,2-a]pyrazine as μ-Opioid Receptor Antagonists

Journal of medicinal chemistry, 2006-12, Vol.49 (25), p.7290-7306

2006

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Further studies of tyrosine surrogates in opioid receptor peptide ligands

Bioorganic & medicinal chemistry letters, 2007-05, Vol.17 (9), p.2656-2660

2007

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(4-Carboxamido)phenylalanine is a surrogate for tyrosine in opioid receptor peptide ligands

Bioorganic & medicinal chemistry letters, 2004-07, Vol.14 (13), p.3545-3548

2004

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Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as μ opioid receptor antagonists with improved opioid receptor selectivity profiles

Bioorganic & medicinal chemistry, 2008-03, Vol.18 (6), p.2006-2012

2008

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trans-3,4-Dimethyl-4-(3-carboxamidophenyl)piperidines: A novel class of μ-selective opioid antagonists

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (24), p.4459-4462

2003

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Arylacetamide κ opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity

Bioorganic & medicinal chemistry letters, 2005-05, Vol.15 (10), p.2647-2652

2005

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Azepinone as a conformational constraint in the design of κ-opioid receptor agonists

Bioorganic & medicinal chemistry letters, 2004-11, Vol.14 (22), p.5693-5697

2004

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Novel malonamide derivatives as potent [kappa] opioid receptor agonists

Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (7), p.1951-1955

2007

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Synthesis and structure-activity relationships of a new series of 2alpha-substituted trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine as mu-selective opioid antagonists

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (4), p.864-868

2006

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Synthesis and structure–activity relationships of a new series of 2α-substituted trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine as μ-selective opioid antagonists

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (4), p.864-868

2006

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Novel phenylamino acetamide derivatives as potent and selective κ opioid receptor agonists

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (3), p.645-648

2006

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trans-3,4-dimethyl-4-(3-carboxamidophenyl)piperidines: a novel class of micro-selective opioid antagonists

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (24), p.4459-4462

2003

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Effects of amyloid peptides on cell viability and expression of neuropeptides in cultured rat dorsal root ganglion neurons: a role for free radicals and protein kinase C

The European journal of neuroscience, 2001-03, Vol.13 (6), p.1125-1135

2001

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Expression of calcitonin gene-related peptide and substance P in cultured dorsal root ganglion neurons following chronic exposure to opiates

Belanger, Serge Denis

2002

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Synthesis and Structure-Activity Relationships of a New Series of 2α-Substituted trans-4,5-Dimethyl-4-(3-hydroxyphenyl)piperidines as μ-Selective Opioid Antagonists

ChemInform, 2006-05, Vol.37 (19), p.no-no

2006

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Design and optimisation of a phased array transducer for ultrasonic inspection of large forged steel ingots

NDT & E international : independent nondestructive testing and evaluation, 2019-04, Vol.103, p.119-129

2019

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Inhibition impairments in Alzheimer's disease, mild cognitive impairment and healthy aging: Effect of congruency proportion in a Stroop task

Neuropsychologia, 2010-01, Vol.48 (2), p.581-590

2010

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Highly efficient polycarbazole-based organic photovoltaic devices

Applied physics letters, 2009-08, Vol.95 (6), p.063304-063304-3

2009

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Validation and refinement of a clinical decision rule for the use of computed tomography in children with minor head injury in the emergency department

Canadian Medical Association journal (CMAJ), 2018-07, Vol.190 (27), p.E816-E822

2018

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Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints

Spirocyclic Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-3-hydroxy-4-(spiro[chromene-2,4′-piperidine]-4-yl) Benzamide (ADL5747)

Potent, Orally Bioavailable Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-4-(5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl)benzamide (ADL5859)

Synthesis and Pharmacological Evaluation of Novel Octahydro-1H-pyrido[1,2-a]pyrazine as μ-Opioid Receptor Antagonists

Novel malonamide derivatives as potent κ opioid receptor agonists

Elucidation of the Bioactive Conformation of the N-Substituted trans-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine Class of μ-Opioid Receptor Antagonists

Synthesis and Pharmacological Evaluation of Novel Octahydro-1 H -pyrido[1,2-a]pyrazine as μ-Opioid Receptor Antagonists

Further studies of tyrosine surrogates in opioid receptor peptide ligands

(4-Carboxamido)phenylalanine is a surrogate for tyrosine in opioid receptor peptide ligands

Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as μ opioid receptor antagonists with improved opioid receptor selectivity profiles

trans-3,4-Dimethyl-4-(3-carboxamidophenyl)piperidines: A novel class of μ-selective opioid antagonists

Arylacetamide κ opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity

Azepinone as a conformational constraint in the design of κ-opioid receptor agonists

Novel malonamide derivatives as potent [kappa] opioid receptor agonists

Synthesis and structure-activity relationships of a new series of 2alpha-substituted trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine as mu-selective opioid antagonists

Synthesis and structure–activity relationships of a new series of 2α-substituted trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine as μ-selective opioid antagonists

Novel phenylamino acetamide derivatives as potent and selective κ opioid receptor agonists

trans-3,4-dimethyl-4-(3-carboxamidophenyl)piperidines: a novel class of micro-selective opioid antagonists

Effects of amyloid peptides on cell viability and expression of neuropeptides in cultured rat dorsal root ganglion neurons: a role for free radicals and protein kinase C

Expression of calcitonin gene-related peptide and substance P in cultured dorsal root ganglion neurons following chronic exposure to opiates

Synthesis and Structure-Activity Relationships of a New Series of 2α-Substituted trans-4,5-Dimethyl-4-(3-hydroxyphenyl)piperidines as μ-Selective Opioid Antagonists

Design and optimisation of a phased array transducer for ultrasonic inspection of large forged steel ingots

Inhibition impairments in Alzheimer's disease, mild cognitive impairment and healthy aging: Effect of congruency proportion in a Stroop task

Highly efficient polycarbazole-based organic photovoltaic devices

Validation and refinement of a clinical decision rule for the use of computed tomography in children with minor head injury in the emergency department

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