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Target-Based Identification and Optimization of 5‑Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay

Journal of medicinal chemistry, 2020-08, Vol.63 (15), p.8276-8295

2020

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Distinct effects of IPSU and suvorexant on mouse sleep architecture

Frontiers in neuroscience, 2013-01, Vol.7, p.235

2013

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Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors

Frontiers in neuroscience, 2013-01, Vol.7, p.230

2013

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Identification of a Novel Series of Orexin Receptor Antagonists with a Distinct Effect on Sleep Architecture for the Treatment of Insomnia

Journal of medicinal chemistry, 2013-10, Vol.56 (19), p.7590-7607

2013

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NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo

Cell stem cell, 2024-04, Vol.31 (4), p.554-569.e17

2024

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Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist

ACS medicinal chemistry letters, 2022-04, Vol.13 (4), p.658-664

2022

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Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs)

Bioorganic & medicinal chemistry letters, 2015-12, Vol.25 (23), p.5555-5560

2015

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Discovery of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel, allosteric mGluR5 antagonists

Bioorganic & medicinal chemistry letters, 2012-10, Vol.22 (20), p.6454-6459

2012

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Discovery of 1 H -pyrazolo[3,4- b ]pyridines as potent dual orexin receptor antagonists (DORAs)

Bioorganic & medicinal chemistry letters, 2015-12, Vol.25 (23), p.5555-5560

2015

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A Novel Three-Component One-Pot Synthesis of 1H-Imidazol-4-yl-pyridines

Organic letters, 2005-01, Vol.7 (1), p.39-42

2005

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Discovery of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel, allosteric mGluRS antagonists

Bioorganic & medicinal chemistry letters, 2012, Vol.22 (20), p.6454-6459

2012

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A Novel Three-Component One-Pot Synthesis of 1H-Imidazol-4-yl-pyridines

Organic letters, 2005-06, Vol.7 (12), p.2517-2518

2005

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Substituted 2-(Cyanomethyl-amino)-acetamides by a Novel Three-Component Reaction

Synlett, 2004-03, Vol.2004 (4), p.688-692

2004

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A Novel Three-Component One-Pot Synthesis of 1 H -Imidazol-4-yl-pyridines

Organic letters, 2005-06, Vol.7 (12), p.2517-2518

2005

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A Novel Three-Component One-Pot Synthesis of 1 H -Imidazol-4-yl-pyridines

Organic letters, 2005-01, Vol.7 (1), p.39-42

2005

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Forskolin Studies

Tetrahedron, 2000-02, Vol.56 (8), p.1081-1095

2000

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An allylic isoprenoid C5 nucleophile for the synthesis of forskolin

Tetrahedron letters, 1997-10, Vol.38 (40), p.7059-7062

1997

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Spatial Cognition VIII: International Conference, Spatial Cognition 2012, Kloster Seeon, Germany, August 31 - September 3, 2012, Proceedings

1, 2012

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An allylic isoprenoid C 5 nucleophile for the synthesis of forskolin

Tetrahedron letters, 1997-10, Vol.38 (40), p.7059-7062

1997

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Evolutionary Chemistry Approach toward Finding Novel Inhibitors of the Type 2 Diabetes Target Glucose-6-phosphate Translocase

Journal of combinatorial chemistry, 2005-03, Vol.7 (2), p.218-226

2005

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A Novel Three-Component One-Pot Synthesis of 1H-Imidazol-4-yl-pyridines

ChemInform, 2005-05, Vol.36 (20), p.no-no

2005

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Substituted 2-(Cyanomethyl-amino)-acetamides by a Novel Three-Component Reaction

ChemInform, 2004-07, Vol.35 (30), p.no-no

2004

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ChemInform Abstract: Forskolin Studies

ChemInform, 2000-05, Vol.31 (22), p.no-no

2000

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Approximate triangulation and region growing for efficient segmentation and smoothing of range images

Robotics and autonomous systems, 2014-09, Vol.62 (9), p.1282-1293

2014

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Registration of non-uniform density 3D laser scans for mapping with micro aerial vehicles

Robotics and autonomous systems, 2015-12, Vol.74, p.318-330

2015

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Target-Based Identification and Optimization of 5‑Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay

Distinct effects of IPSU and suvorexant on mouse sleep architecture

Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors

Identification of a Novel Series of Orexin Receptor Antagonists with a Distinct Effect on Sleep Architecture for the Treatment of Insomnia

NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo

Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist

Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs)

Discovery of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel, allosteric mGluR5 antagonists

Discovery of 1 H -pyrazolo[3,4- b ]pyridines as potent dual orexin receptor antagonists (DORAs)

A Novel Three-Component One-Pot Synthesis of 1H-Imidazol-4-yl-pyridines

Discovery of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel, allosteric mGluRS antagonists

A Novel Three-Component One-Pot Synthesis of 1H-Imidazol-4-yl-pyridines

Substituted 2-(Cyanomethyl-amino)-acetamides by a Novel Three-Component Reaction

A Novel Three-Component One-Pot Synthesis of 1 H -Imidazol-4-yl-pyridines

A Novel Three-Component One-Pot Synthesis of 1 H -Imidazol-4-yl-pyridines

Forskolin Studies

An allylic isoprenoid C5 nucleophile for the synthesis of forskolin

Spatial Cognition VIII: International Conference, Spatial Cognition 2012, Kloster Seeon, Germany, August 31 - September 3, 2012, Proceedings

An allylic isoprenoid C 5 nucleophile for the synthesis of forskolin

Evolutionary Chemistry Approach toward Finding Novel Inhibitors of the Type 2 Diabetes Target Glucose-6-phosphate Translocase

A Novel Three-Component One-Pot Synthesis of 1H-Imidazol-4-yl-pyridines

Substituted 2-(Cyanomethyl-amino)-acetamides by a Novel Three-Component Reaction

ChemInform Abstract: Forskolin Studies

Approximate triangulation and region growing for efficient segmentation and smoothing of range images

Registration of non-uniform density 3D laser scans for mapping with micro aerial vehicles

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