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Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer

Journal of medicinal chemistry, 2021-07, Vol.64 (13), p.9056-9077

2021

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Development of (Trimethylsilyl)ethyl Ester Protected Enolates and Applications in Palladium-Catalyzed Enantioselective Allylic Alkylation: Intermolecular Cross-Coupling of Functionalized Electrophiles

Organic letters, 2014-05, Vol.16 (9), p.2314-2317

2014

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The Reaction Mechanism of the Enantioselective Tsuji Allylation: Inner-Sphere and Outer-Sphere Pathways, Internal Rearrangements, and Asymmetric C–C Bond Formation

Journal of the American Chemical Society, 2012-11, Vol.134 (46), p.19050-19060

2012

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Biology and Chemistry of the Zoanthamine Alkaloids

Angewandte Chemie (International ed.), 2008-03, Vol.47 (13), p.2365-2386

2008

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Enantioselective Decarboxylative Alkylation Reactions: Catalyst Development, Substrate Scope, and Mechanistic Studies

Chemistry : a European journal, 2011-12, Vol.17 (50), p.14199-14223

2011

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Palladium-Catalyzed Enantioselective Decarboxylative Allylic Alkylation of Cyclopentanones

Organic letters, 2015-11, Vol.17 (21), p.5160-5163

2015

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Unusual Allylpalladium Carboxylate Complexes: Identification of the Resting State of Catalytic Enantioselective Decarboxylative Allylic Alkylation Reactions of Ketones

Angewandte Chemie (International ed.), 2009-09, Vol.48 (37), p.6840-6843

2009

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Catalytic Enantioselective Decarboxylative Protonation

Journal of the American Chemical Society, 2006-09, Vol.128 (35), p.11348-11349

2006

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Synthesis of the Carbocyclic Core of Zoanthenol: Implementation of an Unusual Acid-Catalyzed Cyclization

Angewandte Chemie (International ed.), 2007-05, Vol.46 (22), p.4077-4080

2007

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Confirmation of the absolute configuration of (−)-aurantioclavine

Tetrahedron letters, 2011-04, Vol.52 (17), p.2152-2154

2011

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The Enantioselective Tsuji Allylation

Journal of the American Chemical Society, 2004-11, Vol.126 (46), p.15044-15045

2004

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Enantioselective Synthesis of α-Secondary and α-Tertiary Piperazin-2-ones and Piperazines by Catalytic Asymmetric Allylic Alkylation

Angewandte Chemie (International ed.), 2015-01, Vol.54 (1), p.179-183

International ed. in English, 2015

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Enantioselective construction of quaternary N-heterocycles by palladium-catalysed decarboxylative allylic alkylation of lactams

Nature chemistry, 2011-12, Vol.4 (2), p.130-133

2011

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Formal total syntheses of classic natural product target molecules via palladium-catalyzed enantioselective alkylation

Beilstein journal of organic chemistry, 2014-10, Vol.10 (1), p.2501-2512

2014

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Deracemization of Quaternary Stereocenters by Pd-Catalyzed Enantioconvergent Decarboxylative Allylation of Racemic β-Ketoesters

Angewandte Chemie (International ed.), 2005-10, Vol.44 (42), p.6924-6927

2005

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Discovery of N‑((3R,4R)‑4-Fluoro-1-(6-((3-methoxy-1-methyl‑1H‑pyrazol-4-yl)amino)-9-methyl‑9H‑purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.3002-3019

2017

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A Facile and Modular Synthesis of Phosphinooxazoline Ligands

Organic letters, 2007-06, Vol.9 (13), p.2529-2531

2007

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Expanding Insight into Asymmetric Palladium-Catalyzed Allylic Alkylation of N-Heterocyclic Molecules and Cyclic Ketones

Chemistry : a European journal, 2013-04, Vol.19 (14), p.4414-4418

2013

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Simple Enantioselective Approach to Synthetic Limonoids

Journal of the American Chemical Society, 2008-05, Vol.130 (21), p.6720-6721

2008

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Enantioselective Synthesis of Caprolactam and Enone Precursors to the Heterocyclic DEFG Ring System of Zoanthenol

European Journal of Organic Chemistry, 2016-04, Vol.2016 (12), p.2101-2104

2016

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Complexation of Peptidoglycan Intermediates by the Lipoglycodepsipeptide Antibiotic Ramoplanin: Minimal Structural Requirements for Intermolecular Complexation and Fibril Formation

Proceedings of the National Academy of Sciences - PNAS, 2002-05, Vol.99 (11), p.7384-7389

2002

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The Inner-Sphere Process in the Enantioselective Tsuji Allylation Reaction with (S)-t-Bu-phosphinooxazoline Ligands

Journal of the American Chemical Society, 2007-10, Vol.129 (39), p.11876-11877

2007

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An efficient synthesis of the carbocyclic core of zoanthenol

Tetrahedron, 2009-08, Vol.65 (33), p.6571-6575

2009

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Unexpected decarbonylation during an acid-mediated cyclization to access the carbocyclic core of zoanthenol

Tetrahedron letters, 2009-07, Vol.50 (26), p.3182-3184

2009

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Enantioselective Synthesis of α-Secondary and α-Tertiary Piperazin-2-ones and Piperazines by Catalytic Asymmetric Allylic Alkylation

Angewandte Chemie, 2015-01, Vol.127 (1), p.181-185

2015

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Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer

Development of (Trimethylsilyl)ethyl Ester Protected Enolates and Applications in Palladium-Catalyzed Enantioselective Allylic Alkylation: Intermolecular Cross-Coupling of Functionalized Electrophiles

The Reaction Mechanism of the Enantioselective Tsuji Allylation: Inner-Sphere and Outer-Sphere Pathways, Internal Rearrangements, and Asymmetric C–C Bond Formation

Biology and Chemistry of the Zoanthamine Alkaloids

Enantioselective Decarboxylative Alkylation Reactions: Catalyst Development, Substrate Scope, and Mechanistic Studies

Palladium-Catalyzed Enantioselective Decarboxylative Allylic Alkylation of Cyclopentanones

Unusual Allylpalladium Carboxylate Complexes: Identification of the Resting State of Catalytic Enantioselective Decarboxylative Allylic Alkylation Reactions of Ketones

Catalytic Enantioselective Decarboxylative Protonation

Synthesis of the Carbocyclic Core of Zoanthenol: Implementation of an Unusual Acid-Catalyzed Cyclization

Confirmation of the absolute configuration of (−)-aurantioclavine

The Enantioselective Tsuji Allylation

Enantioselective Synthesis of α-Secondary and α-Tertiary Piperazin-2-ones and Piperazines by Catalytic Asymmetric Allylic Alkylation

Enantioselective construction of quaternary N-heterocycles by palladium-catalysed decarboxylative allylic alkylation of lactams

Formal total syntheses of classic natural product target molecules via palladium-catalyzed enantioselective alkylation

Deracemization of Quaternary Stereocenters by Pd-Catalyzed Enantioconvergent Decarboxylative Allylation of Racemic β-Ketoesters

A Facile and Modular Synthesis of Phosphinooxazoline Ligands

Expanding Insight into Asymmetric Palladium-Catalyzed Allylic Alkylation of N-Heterocyclic Molecules and Cyclic Ketones

Simple Enantioselective Approach to Synthetic Limonoids

Enantioselective Synthesis of Caprolactam and Enone Precursors to the Heterocyclic DEFG Ring System of Zoanthenol

Complexation of Peptidoglycan Intermediates by the Lipoglycodepsipeptide Antibiotic Ramoplanin: Minimal Structural Requirements for Intermolecular Complexation and Fibril Formation

The Inner-Sphere Process in the Enantioselective Tsuji Allylation Reaction with (S)-t-Bu-phosphinooxazoline Ligands

An efficient synthesis of the carbocyclic core of zoanthenol

Unexpected decarbonylation during an acid-mediated cyclization to access the carbocyclic core of zoanthenol

Enantioselective Synthesis of α-Secondary and α-Tertiary Piperazin-2-ones and Piperazines by Catalytic Asymmetric Allylic Alkylation

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