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Submicron Size Particles of a Murine Monoclonal Antibody Are More Immunogenic Than Soluble Oligomers or Micron Size Particles Upon Subcutaneous Administration in Mice

Journal of pharmaceutical sciences, 2018-11, Vol.107 (11), p.2847-2859

2018

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Gelation of a Monoclonal Antibody at the Silicone Oil–Water Interface and Subsequent Rupture of the Interfacial Gel Results in Aggregation and Particle Formation

Journal of pharmaceutical sciences, 2015-04, Vol.104 (4), p.1282-1290

2015

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Development of a stable lyophilized adeno-associated virus gene therapy formulation

International journal of pharmaceutics, 2021-09, Vol.606, p.120912-120912, Article 120912

2021

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Comparative Thermodynamics of the Reversible Self-Association of Therapeutic mAbs Reveal Opposing Roles for Linked Proton- and Ion-Binding Events

Pharmaceutical research, 2023-06, Vol.40 (6), p.1383-1397

2023

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Protein Aggregation and Particle Formation in Prefilled Glass Syringes

Journal of pharmaceutical sciences, 2014-06, Vol.103 (6), p.1601-1612

2014

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Quantitation of Trace Levels of DNA Released from Disrupted Adeno-Associated Virus Gene Therapy Vectors

Journal of pharmaceutical sciences, 2021-09, Vol.110 (9), p.3183-3187

2021

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Trace levels of the CHO host cell protease cathepsin D caused particle formation in a monoclonal antibody product

Biotechnology progress, 2015-09, Vol.31 (5), p.1360-1369

2015

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Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody

The Journal of biological chemistry, 2018-06, Vol.293 (22), p.8439-8448

2018

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Effects of Surfaces and Leachables on the Stability of Biopharmaceuticals

Journal of pharmaceutical sciences, 2011-10, Vol.100 (10), p.4158-4170

2011

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Impact of Time Out of Intended Storage and Freeze-thaw Rates on the Stability of Adeno-associated Virus 8 and 9

Journal of pharmaceutical sciences, 2022-05, Vol.111 (5), p.1346-1353

2022

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Mechanistic Studies and Formulation Mitigations of Adeno-associated Virus Capsid Rupture During Freezing and Thawing: Mechanisms of Freeze/Thaw Induced AAV Rupture

Journal of pharmaceutical sciences, 2022-07, Vol.111 (7), p.1868-1878

2022

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Ionic Strength Affects Tertiary Structure and Aggregation Propensity of a Monoclonal Antibody Adsorbed to Silicone Oil–Water Interfaces

Journal of pharmaceutical sciences, 2013-02, Vol.102 (2), p.429-440

2013

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Response of a concentrated monoclonal antibody formulation to high shear

Biotechnology and bioengineering, 2009-08, Vol.103 (5), p.936-943

2009

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Monoclonal Antibody Dimers Induced by Low pH, Heat, or Light Exposure Are Not Immunogenic Upon Subcutaneous Administration in a Mouse Model

Journal of pharmaceutical sciences, 2020-01, Vol.109 (1), p.730-738

2020

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Energetic Dissection of Mab-Specific Reversible Self-Association Reveals Unique Thermodynamic Signatures

Pharmaceutical research, 2021-02, Vol.38 (2), p.243-255

2021

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Generation and Characterization of an IgG4 Monomeric Fc Platform

PloS one, 2016-08, Vol.11 (8), p.e0160345

2016

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Determination of Interaction Parameters for Reversibly Self-Associating Antibodies: A Comparative Analysis

Journal of pharmaceutical sciences, 2018-07, Vol.107 (7), p.1820-1830

2018

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Analytical characterization of coformulated antibodies as combination therapy

mAbs, 2020-01, Vol.12 (1), p.1738691

2020

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Aggregation of a monoclonal antibody induced by adsorption to stainless steel

Biotechnology and bioengineering, 2010-01, Vol.105 (1), p.121-129

2010

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The future of protein particle characterization and understanding its potential to diminish the immunogenicity of biopharmaceuticals: A shared perspective

Journal of pharmaceutical sciences, 2012-10, Vol.101 (10), p.3580-3585

2012

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Production of particles of therapeutic proteins at the air-water interface during compression/dilation cycles

Soft matter, 2012-01, Vol.8 (4), p.1329-1335

2012

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Precipitation of a Monoclonal Antibody by Soluble Tungsten

Journal of pharmaceutical sciences, 2009-09, Vol.98 (9), p.3290-3301

2009

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Monoclonal antibody interactions with micro- and nanoparticles: Adsorption, aggregation, and accelerated stress studies

Journal of pharmaceutical sciences, 2009-09, Vol.98 (9), p.3218-3238

2009

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Fate of Multimeric Oligomers, Submicron, and Micron Size Aggregates of Monoclonal Antibodies Upon Subcutaneous Injection in Mice

Journal of pharmaceutical sciences, 2016-05, Vol.105 (5), p.1693-1704

2016

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Identification of an IgG CDR sequence contributing to co‐purification of the host cell protease cathepsin D

Biotechnology progress, 2017-01, Vol.33 (1), p.140-145

2017

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Submicron Size Particles of a Murine Monoclonal Antibody Are More Immunogenic Than Soluble Oligomers or Micron Size Particles Upon Subcutaneous Administration in Mice

Gelation of a Monoclonal Antibody at the Silicone Oil–Water Interface and Subsequent Rupture of the Interfacial Gel Results in Aggregation and Particle Formation

Development of a stable lyophilized adeno-associated virus gene therapy formulation

Comparative Thermodynamics of the Reversible Self-Association of Therapeutic mAbs Reveal Opposing Roles for Linked Proton- and Ion-Binding Events

Protein Aggregation and Particle Formation in Prefilled Glass Syringes

Quantitation of Trace Levels of DNA Released from Disrupted Adeno-Associated Virus Gene Therapy Vectors

Trace levels of the CHO host cell protease cathepsin D caused particle formation in a monoclonal antibody product

Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody

Effects of Surfaces and Leachables on the Stability of Biopharmaceuticals

Impact of Time Out of Intended Storage and Freeze-thaw Rates on the Stability of Adeno-associated Virus 8 and 9

Mechanistic Studies and Formulation Mitigations of Adeno-associated Virus Capsid Rupture During Freezing and Thawing: Mechanisms of Freeze/Thaw Induced AAV Rupture

Ionic Strength Affects Tertiary Structure and Aggregation Propensity of a Monoclonal Antibody Adsorbed to Silicone Oil–Water Interfaces

Response of a concentrated monoclonal antibody formulation to high shear

Monoclonal Antibody Dimers Induced by Low pH, Heat, or Light Exposure Are Not Immunogenic Upon Subcutaneous Administration in a Mouse Model

Energetic Dissection of Mab-Specific Reversible Self-Association Reveals Unique Thermodynamic Signatures

Generation and Characterization of an IgG4 Monomeric Fc Platform

Determination of Interaction Parameters for Reversibly Self-Associating Antibodies: A Comparative Analysis

Analytical characterization of coformulated antibodies as combination therapy

Aggregation of a monoclonal antibody induced by adsorption to stainless steel

The future of protein particle characterization and understanding its potential to diminish the immunogenicity of biopharmaceuticals: A shared perspective

Production of particles of therapeutic proteins at the air-water interface during compression/dilation cycles

Precipitation of a Monoclonal Antibody by Soluble Tungsten

Monoclonal antibody interactions with micro- and nanoparticles: Adsorption, aggregation, and accelerated stress studies

Fate of Multimeric Oligomers, Submicron, and Micron Size Aggregates of Monoclonal Antibodies Upon Subcutaneous Injection in Mice

Identification of an IgG CDR sequence contributing to co‐purification of the host cell protease cathepsin D

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