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MT1‐MMP and ADAM10/17 exhibit a remarkable overlap of shedding properties

The FEBS journal, 2023-01, Vol.290 (1), p.93-111

2023

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Meprin and ADAM proteases as triggers of systemic inflammation in sepsis

FEBS letters, 2022-03, Vol.596 (5), p.534-556

2022

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Propeptide glycosylation and galectin‐3 binding decrease proteolytic activation of human proMMP‐9/progelatinase B

The FEBS journal, 2019-03, Vol.286 (5), p.930-945

2019

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Determination of cleavage site of Reelin between its sixth and seventh repeat and contribution of meprin metalloproteases to the cleavage

Journal of biochemistry (Tokyo), 2016-03, Vol.159 (3), p.305-312

2016

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Phosphorylation of meprin β controls its cell surface abundance and subsequently diminishes ectodomain shedding

The FASEB journal, 2021-07, Vol.35 (7), p.e21677-n/a

2021

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Inhibitors of BMP‐1/tolloid‐like proteinases: efficacy, selectivity and cellular toxicity

FEBS open bio, 2018-12, Vol.8 (12), p.2011-2021

2018

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Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus

Proceedings of the National Academy of Sciences - PNAS, 2014-08, Vol.111 (34), p.12396-12401

2014

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Meprin β cleaves TREM2 and controls its phagocytic activity on macrophages

The FASEB journal, 2020-05, Vol.34 (5), p.6675-6687

2020

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Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation

PLoS biology, 2017-01, Vol.15 (1), p.e2000080-e2000080

2017

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LC–MS Based Cleavage Site Profiling of the Proteases ADAM10 and ADAM17 Using Proteome-Derived Peptide Libraries

Journal of proteome research, 2014-04, Vol.13 (4), p.2205-2214

2014

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Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP

International journal of molecular sciences, 2019-07, Vol.20 (15), p.3677

2019

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The metalloprotease ADAMTS4 generates N-truncated Aβ4–x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer’s disease

Acta neuropathologica, 2019-02, Vol.137 (2), p.239-257

2019

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IL-6 trans-signaling in the brain influences the behavioral and physio-pathological phenotype of the Tg2576 and 3xTgAD mouse models of Alzheimer’s disease

Brain, behavior, and immunity, 2019-11, Vol.82, p.145-159

2019

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Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage

The FASEB journal, 2019-11, Vol.33 (11), p.11925-11940

2019

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TMPRSS4 is a type II transmembrane serine protease involved in cancer and viral infections

Biological chemistry, 2012-09, Vol.393 (9), p.907-914

2012

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Calcium negatively regulates meprin β activity and attenuates substrate cleavage

The FASEB journal, 2015-08, Vol.29 (8), p.3549-3557

2015

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Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strength

Proceedings of the National Academy of Sciences - PNAS, 2013-08, Vol.110 (35), p.14219-14224

2013

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Identification of PCPE-2 as the endogenous specific inhibitor of human BMP-1/tolloid-like proteinases

Nature communications, 2023-12, Vol.14 (1), p.8020-8020, Article 8020

2023

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Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro

Scientific reports, 2020-12, Vol.10 (1), p.21612-21612, Article 21612

2020

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Structural basis for the sheddase function of human meprin β metalloproteinase at the plasma membrane

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (40), p.16131-16136

2012

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Human and Murine Interleukin 23 Receptors Are Novel Substrates for A Disintegrin and Metalloproteases ADAM10 and ADAM17

The Journal of biological chemistry, 2016-05, Vol.291 (20), p.10551-10561

2016

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Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation

Biological chemistry, 2010-04, Vol.391 (4), p.455-460

2010

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Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate

Scientific reports, 2016-12, Vol.6 (1), p.11-17, Article 11

2016

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Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB

Cell reports (Cambridge), 2017-11, Vol.21 (8), p.2090-2103

2017

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Processing of Procollagen III by Meprins: New Players in Extracellular Matrix Assembly?

Journal of investigative dermatology, 2010-12, Vol.130 (12), p.2727-2735

2010

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MT1‐MMP and ADAM10/17 exhibit a remarkable overlap of shedding properties

Meprin and ADAM proteases as triggers of systemic inflammation in sepsis

Propeptide glycosylation and galectin‐3 binding decrease proteolytic activation of human proMMP‐9/progelatinase B

Determination of cleavage site of Reelin between its sixth and seventh repeat and contribution of meprin metalloproteases to the cleavage

Phosphorylation of meprin β controls its cell surface abundance and subsequently diminishes ectodomain shedding

Inhibitors of BMP‐1/tolloid‐like proteinases: efficacy, selectivity and cellular toxicity

Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus

Meprin β cleaves TREM2 and controls its phagocytic activity on macrophages

Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation

LC–MS Based Cleavage Site Profiling of the Proteases ADAM10 and ADAM17 Using Proteome-Derived Peptide Libraries

Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP

The metalloprotease ADAMTS4 generates N-truncated Aβ4–x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer’s disease

IL-6 trans-signaling in the brain influences the behavioral and physio-pathological phenotype of the Tg2576 and 3xTgAD mouse models of Alzheimer’s disease

Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage

TMPRSS4 is a type II transmembrane serine protease involved in cancer and viral infections

Calcium negatively regulates meprin β activity and attenuates substrate cleavage

Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strength

Identification of PCPE-2 as the endogenous specific inhibitor of human BMP-1/tolloid-like proteinases

Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro

Structural basis for the sheddase function of human meprin β metalloproteinase at the plasma membrane

Human and Murine Interleukin 23 Receptors Are Novel Substrates for A Disintegrin and Metalloproteases ADAM10 and ADAM17

Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation

Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate

Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB

Processing of Procollagen III by Meprins: New Players in Extracellular Matrix Assembly?

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