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Hyperexcitability in young iPSC-derived C9ORF72 mutant motor neurons is associated with increased intracellular calcium release

Scientific reports, 2022-05, Vol.12 (1), p.7378-8, Article 7378

2022

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Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice

eLife, 2017-09, Vol.6

2017

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Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice

Frontiers in cellular neuroscience, 2014-09, Vol.8, p.301-301

2014

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From Synaptic Dysfunction to Neuroprotective Strategies in Genetic Parkinson's Disease: Lessons From LRRK2

Frontiers in cellular neuroscience, 2020-07, Vol.14, p.158-158

2020

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Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson’s iPSC-dopamine neurons

iScience, 2023-07, Vol.26 (7), p.107044-107044, Article 107044

2023

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Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson's disease

Nature communications, 2019-11, Vol.10 (1), p.5094-11, Article 5094

2019

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LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory

Human molecular genetics, 2015-03, Vol.24 (5), p.1336-1349

2015

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Leptin : A Novel Therapeutic Target in Alzheimer's Disease?

International journal of alzheimer's disease, 2012, Vol.2012 (2012), p.1-7

2012

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Application of CRISPR/Cas9 editing and digital droplet PCR in human iPSCs to generate novel knock-in reporter lines to visualize dopaminergic neurons

Stem cell research, 2019-12, Vol.41, p.101656-101656, Article 101656

2019

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Early deficits in an in vitro striatal microcircuit model carrying the Parkinson's GBA-N370S mutation

NPJ Parkinson's Disease, 2024-04, Vol.10 (1), p.82-82, Article 82

2024

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Atypical Progressive Supranuclear Palsy With Corticospinal Tract Degeneration

Journal of neuropathology and experimental neurology, 2006-04, Vol.65 (4), p.396-405

2006

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Robotic multiwell planar patch-clamp for native and primary mammalian cells

Nature protocols, 2009-02, Vol.4 (2), p.244-255

2009

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Impaired dopamine release in Parkinson’s disease

Brain (London, England : 1878), 2023-08, Vol.146 (8), p.3117-3132

2023

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Palmitoylation of δ-catenin by DHHC5 mediates activity-induced synapse plasticity

Nature neuroscience, 2014-04, Vol.17 (4), p.522-532

2014

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Leptin prevents hippocampal synaptic disruption and neuronal cell death induced by amyloid β

Neurobiology of aging, 2013, Vol.34 (1), p.226-237

2013

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Tau depletion in human neurons mitigates Aβ-driven toxicity

Molecular psychiatry, 2024-02, Vol.29 (7), p.2009-2020

2024

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Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging

Journal of Parkinson's disease, 2014, Vol.4 (3), p.483-498

2014

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Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release

Parkinsonism & related disorders, 2015-10, Vol.21 (10), p.1156-1163

2015

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Leptin prevents hippocampal synaptic disruption and neuronal cell death induced by amyloid [beta]

Neurobiology of aging, 2013-01, Vol.34 (1), p.226-237

2013

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Palmitoylation of [delta]-catenin by DHHC5 mediates activity-induced synapse plasticity

Nature neuroscience, 2014-04, Vol.17 (4), p.522

2014

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Tackling underrepresentation to aid understanding of Parkinson’s disease: Progress and further opportunities

Physiology News, 2021-09

2021

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Tackling underrepresentation to aid understanding of Parkinson’s disease: Progress and further opportunities

Physiology News, 2021-09 (Autumn 123)

2021

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Robotic multi-well planar patch-clamp for native and primary mammalian cells

Nature protocols, 2009-01, Vol.4 (2), p.244-255

2009

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Hyperexcitability in young iPSC-derived C9ORF72 mutant motor neurons is associated with increased intracellular calcium release

Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice

Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice

From Synaptic Dysfunction to Neuroprotective Strategies in Genetic Parkinson's Disease: Lessons From LRRK2

Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson’s iPSC-dopamine neurons

Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson's disease

LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory

Leptin : A Novel Therapeutic Target in Alzheimer's Disease?

Application of CRISPR/Cas9 editing and digital droplet PCR in human iPSCs to generate novel knock-in reporter lines to visualize dopaminergic neurons

Early deficits in an in vitro striatal microcircuit model carrying the Parkinson's GBA-N370S mutation

Atypical Progressive Supranuclear Palsy With Corticospinal Tract Degeneration

Robotic multiwell planar patch-clamp for native and primary mammalian cells

Impaired dopamine release in Parkinson’s disease

Palmitoylation of δ-catenin by DHHC5 mediates activity-induced synapse plasticity

Leptin prevents hippocampal synaptic disruption and neuronal cell death induced by amyloid β

Tau depletion in human neurons mitigates Aβ-driven toxicity

DNAJC13 mutations in Parkinson disease

Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging

Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release

Leptin prevents hippocampal synaptic disruption and neuronal cell death induced by amyloid [beta]

Palmitoylation of [delta]-catenin by DHHC5 mediates activity-induced synapse plasticity

Tackling underrepresentation to aid understanding of Parkinson’s disease: Progress and further opportunities

Tackling underrepresentation to aid understanding of Parkinson’s disease: Progress and further opportunities

Robotic multi-well planar patch-clamp for native and primary mammalian cells

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