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Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use

Pharmacological reviews, 2006-09, Vol.58 (3), p.488-520

2006

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Sildenafil reduces respiratory muscle weakness and fibrosis in the mdx mouse model of Duchenne muscular dystrophy

The Journal of pathology, 2012-09, Vol.228 (1), p.77-87

2012

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Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy

Proceedings of the National Academy of Sciences - PNAS, 2010-11, Vol.107 (44), p.19079-19083

2010

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The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland

Molecular pharmacology, 2011-04, Vol.79 (4), p.639-648

2011

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Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis

Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (35), p.12925-12929

2014

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Cyclic GMP Phosphodiesterases and Regulation of Smooth Muscle Function

Circulation research, 2003-08, Vol.93 (4), p.280-291

2003

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Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes

Proceedings of the National Academy of Sciences - PNAS, 2010-03, Vol.107 (12), p.5646-5651

2010

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Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions

Current opinion in cell biology, 2000-04, Vol.12 (2), p.174-179

2000

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Role of Ca2+/Calmodulin–Stimulated Cyclic Nucleotide Phosphodiesterase 1 in Mediating Cardiomyocyte Hypertrophy

Circulation research, 2009-11, Vol.105 (10), p.956-964

2009

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Differential Regulation of Endothelial Cell Permeability by cGMP via Phosphodiesterases 2 and 3

Circulation research, 2007-10, Vol.101 (8), p.811-818

2007

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Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A

Proceedings of the National Academy of Sciences - PNAS, 2006-12, Vol.103 (52), p.19925-19930

2006

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A yeast-based chemical screen identifies a PDE inhibitor that elevates steroidogenesis in mouse Leydig cells via PDE8 and PDE4 inhibition

PloS one, 2013-08, Vol.8 (8), p.e71279-e71279

2013

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Hydrolysis Products of cAMP Analogs Cause Transformation of Trypanosoma Brucei from Slender to Stumpy-Like Forms

Proceedings of the National Academy of Sciences - PNAS, 2006-12, Vol.103 (50), p.19194-19199

2006

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Phosphodiesterase-8A binds to and regulates Raf-1 kinase

Proceedings of the National Academy of Sciences - PNAS, 2013-04, Vol.110 (16), p.E1533-E1542

2013

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Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages

Proceedings of the National Academy of Sciences - PNAS, 2009-12, Vol.106 (51), p.21978-21983

2009

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Isolation and Characterization of a Dual-Substrate Phosphodiesterase Gene Family: PDE10A

Proceedings of the National Academy of Sciences - PNAS, 1999-06, Vol.96 (12), p.7071-7076

1999

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The Two GAF Domains in Phosphodiesterase 2A Have Distinct Roles in Dimerization and in cGMP Binding

Proceedings of the National Academy of Sciences - PNAS, 2002-10, Vol.99 (20), p.13260-13265

2002

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Regulation of cGMP-specific Phosphodiesterase (PDE5) Phosphorylation in Smooth Muscle Cells

The Journal of biological chemistry, 2002-02, Vol.277 (5), p.3310-3317

2002

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The Structure of the GAF A Domain from Phosphodiesterase 6C Reveals Determinants of cGMP Binding, a Conserved Binding Surface, and a Large cGMP-dependent Conformational Change

The Journal of biological chemistry, 2008-09, Vol.283 (38), p.25913-25919

2008

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mRNA expression patterns of the cGMP-hydrolyzing phosphodiesterases types 2, 5, and 9 during development of the rat brain

Journal of comparative neurology (1911), 2003-12, Vol.467 (4), p.566-580

2003

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Foxp3-dependent programme of regulatory T-cell differentiation

Nature, 2007-02, Vol.445 (7129), p.771-775

2007

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Rosiglitazone Inhibits Acyl-CoA Synthetase Activity and Fatty Acid Partitioning to Diacylglycerol and Triacylglycerol via a Peroxisome Proliferator–Activated Receptor-γ–Independent Mechanism in Human Arterial Smooth Muscle Cells and Macrophages

Diabetes (New York, N.Y.), 2007-04, Vol.56 (4), p.1143-1152

2007

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Phosphodiesterase Type 5: Expanding Roles in Cardiovascular Regulation

Circulation research, 2007-11, Vol.101 (11), p.1084-1095

2007

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Crystal Structure of the Tandem GAF Domains from a Cyanobacterial Adenylyl Cyclase: Modes of Ligand Binding and Dimerization

Proceedings of the National Academy of Sciences - PNAS, 2005-02, Vol.102 (8), p.3082-3087

2005

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Studying mechanisms of cAMP and cyclic nucleotide phosphodiesterase signaling in Leydig cell function with phosphoproteomics

Cellular signalling, 2016-07, Vol.28 (7), p.764-778

2016

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Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use

Sildenafil reduces respiratory muscle weakness and fibrosis in the mdx mouse model of Duchenne muscular dystrophy

Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy

The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland

Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis

Cyclic GMP Phosphodiesterases and Regulation of Smooth Muscle Function

Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes

Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions

Role of Ca2+/Calmodulin–Stimulated Cyclic Nucleotide Phosphodiesterase 1 in Mediating Cardiomyocyte Hypertrophy

Differential Regulation of Endothelial Cell Permeability by cGMP via Phosphodiesterases 2 and 3

Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A

A yeast-based chemical screen identifies a PDE inhibitor that elevates steroidogenesis in mouse Leydig cells via PDE8 and PDE4 inhibition

Hydrolysis Products of cAMP Analogs Cause Transformation of Trypanosoma Brucei from Slender to Stumpy-Like Forms

Phosphodiesterase-8A binds to and regulates Raf-1 kinase

Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages

Isolation and Characterization of a Dual-Substrate Phosphodiesterase Gene Family: PDE10A

The Two GAF Domains in Phosphodiesterase 2A Have Distinct Roles in Dimerization and in cGMP Binding

Regulation of cGMP-specific Phosphodiesterase (PDE5) Phosphorylation in Smooth Muscle Cells

The Structure of the GAF A Domain from Phosphodiesterase 6C Reveals Determinants of cGMP Binding, a Conserved Binding Surface, and a Large cGMP-dependent Conformational Change

mRNA expression patterns of the cGMP-hydrolyzing phosphodiesterases types 2, 5, and 9 during development of the rat brain

Foxp3-dependent programme of regulatory T-cell differentiation

Rosiglitazone Inhibits Acyl-CoA Synthetase Activity and Fatty Acid Partitioning to Diacylglycerol and Triacylglycerol via a Peroxisome Proliferator–Activated Receptor-γ–Independent Mechanism in Human Arterial Smooth Muscle Cells and Macrophages

Phosphodiesterase Type 5: Expanding Roles in Cardiovascular Regulation

Crystal Structure of the Tandem GAF Domains from a Cyanobacterial Adenylyl Cyclase: Modes of Ligand Binding and Dimerization

Studying mechanisms of cAMP and cyclic nucleotide phosphodiesterase signaling in Leydig cell function with phosphoproteomics

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