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Cyclic nucleotide research - still expanding after half a century

Nature reviews. Molecular cell biology, 2002-09, Vol.3 (9), p.710-718

2002

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Cyclic GMP Phosphodiesterases and Regulation of Smooth Muscle Function

Circulation research, 2003-08, Vol.93 (4), p.280-291

2003

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Isolation and Characterization of a Dual-Substrate Phosphodiesterase Gene Family: PDE10A

Proceedings of the National Academy of Sciences - PNAS, 1999-06, Vol.96 (12), p.7071-7076

1999

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Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors

Trends in Pharmacological Sciences, 1990-04, Vol.11 (4), p.150-155

1990

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Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

Physiological reviews, 1995-10, Vol.75 (4), p.725-748

Beavo, J. A

1995

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Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions

Current opinion in cell biology, 2000-04, Vol.12 (2), p.174-179

2000

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The Two GAF Domains in Phosphodiesterase 2A Have Distinct Roles in Dimerization and in cGMP Binding

Proceedings of the National Academy of Sciences - PNAS, 2002-10, Vol.99 (20), p.13260-13265

2002

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PDE5 is converted to an activated state upon cGMP binding to the GAF A domain

The EMBO journal, 2003-02, Vol.22 (3), p.469-478

2003

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Regulation of cGMP-specific Phosphodiesterase (PDE5) Phosphorylation in Smooth Muscle Cells

The Journal of biological chemistry, 2002-02, Vol.277 (5), p.3310-3317

2002

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CD3- and CD28-Dependent Induction of PDE7 Required for T Cell Activation

Science (American Association for the Advancement of Science), 1999-02, Vol.283 (5403), p.848-851

1999

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Molecular Cloning and Characterization of a Distinct Human Phosphodiesterase Gene Family: PDE11A

Proceedings of the National Academy of Sciences - PNAS, 2000-03, Vol.97 (7), p.3702-3707

2000

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mRNA expression patterns of the cGMP-hydrolyzing phosphodiesterases types 2, 5, and 9 during development of the rat brain

Journal of comparative neurology (1911), 2003-12, Vol.467 (4), p.566-580

2003

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Identification and Characterization of a Novel Family of Cyclic Nucleotide Phosphodiesterases

The Journal of biological chemistry, 1998-06, Vol.273 (25), p.15553-15558

1998

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Cloning and Characterization of a cAMP-Specific Cyclic Nucleotide Phosphodiesterase

Proceedings of the National Academy of Sciences - PNAS, 1998-07, Vol.95 (15), p.8991-8996

1998

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Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance

Circulation (New York, N.Y.), 2001-11, Vol.104 (19), p.2338-2265

2001

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A-Kinase Anchoring Proteins Interact with Phosphodiesterases in T Lymphocyte Cell Lines

The Journal of immunology (1950), 2004-10, Vol.173 (8), p.4806-4814

2004

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Crystal Structure of the Tandem GAF Domains from a Cyanobacterial Adenylyl Cyclase: Modes of Ligand Binding and Dimerization

Proceedings of the National Academy of Sciences - PNAS, 2005-02, Vol.102 (8), p.3082-3087

2005

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Leptin Induces Insulin-like Signaling That Antagonizes cAMP Elevation by Glucagon in Hepatocytes

The Journal of biological chemistry, 2000-04, Vol.275 (15), p.11348-11354

2000

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Leptin inhibits insulin secretion by activation of phosphodiesterase 3B

The Journal of clinical investigation, 1998-09, Vol.102 (5), p.869-873

1998

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Multiple cyclic nucleotide phosphodiesterases

Molecular pharmacology, 1994-09, Vol.46 (3), p.399-405

1994

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Molecular Determinants for Cyclic Nucleotide Binding to the Regulatory Domains of Phosphodiesterase 2A

The Journal of biological chemistry, 2004-09, Vol.279 (36), p.37928-37938

2004

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Cyclic Nucleotide Phosphodiesterase 1C Promotes Human Arterial Smooth Muscle Cell Proliferation

Circulation research, 2002-02, Vol.90 (2), p.151-157

2002

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Specific localized expression of cGMP PDEs in Purkinje neurons and macrophages

Neurochemistry international, 2004-11, Vol.45 (6), p.853-857

2004

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T Cell Activation Up-Regulates Cyclic Nucleotide Phosphodiesterases 8A1 and 7A3

Proceedings of the National Academy of Sciences - PNAS, 2001-05, Vol.98 (11), p.6319-6324

2001

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Individual Cerebellar Purkinje Cells Express Different cGMP Phosphodiesterases (PDEs): In Vivo Phosphorylation of cGMP-Specific PDE (PDE5) as an Indicator of cGMP-dependent protein kinase (PKG) Activation

The Journal of neuroscience, 2003-07, Vol.23 (16), p.6452-6459

2003

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Cyclic nucleotide research - still expanding after half a century

Cyclic GMP Phosphodiesterases and Regulation of Smooth Muscle Function

Isolation and Characterization of a Dual-Substrate Phosphodiesterase Gene Family: PDE10A

Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions

The Two GAF Domains in Phosphodiesterase 2A Have Distinct Roles in Dimerization and in cGMP Binding

PDE5 is converted to an activated state upon cGMP binding to the GAF A domain

Regulation of cGMP-specific Phosphodiesterase (PDE5) Phosphorylation in Smooth Muscle Cells

CD3- and CD28-Dependent Induction of PDE7 Required for T Cell Activation

Molecular Cloning and Characterization of a Distinct Human Phosphodiesterase Gene Family: PDE11A

mRNA expression patterns of the cGMP-hydrolyzing phosphodiesterases types 2, 5, and 9 during development of the rat brain

Identification and Characterization of a Novel Family of Cyclic Nucleotide Phosphodiesterases

Cloning and Characterization of a cAMP-Specific Cyclic Nucleotide Phosphodiesterase

Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance

A-Kinase Anchoring Proteins Interact with Phosphodiesterases in T Lymphocyte Cell Lines

Crystal Structure of the Tandem GAF Domains from a Cyanobacterial Adenylyl Cyclase: Modes of Ligand Binding and Dimerization

Leptin Induces Insulin-like Signaling That Antagonizes cAMP Elevation by Glucagon in Hepatocytes

Leptin inhibits insulin secretion by activation of phosphodiesterase 3B

Multiple cyclic nucleotide phosphodiesterases

Molecular Determinants for Cyclic Nucleotide Binding to the Regulatory Domains of Phosphodiesterase 2A

Cyclic Nucleotide Phosphodiesterase 1C Promotes Human Arterial Smooth Muscle Cell Proliferation

Specific localized expression of cGMP PDEs in Purkinje neurons and macrophages

T Cell Activation Up-Regulates Cyclic Nucleotide Phosphodiesterases 8A1 and 7A3

Individual Cerebellar Purkinje Cells Express Different cGMP Phosphodiesterases (PDEs): In Vivo Phosphorylation of cGMP-Specific PDE (PDE5) as an Indicator of cGMP-dependent protein kinase (PKG) Activation

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