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Mechanism of ganciclovir-induced chain termination revealed by resistant viral polymerase mutants with reduced exonuclease activity

Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (49), p.17462-17467

2014

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Crystal Structures of Human Bifunctional Enzyme Aminoimidazole-4-carboxamide Ribonucleotide Transformylase/IMP Cyclohydrolase in Complex with Potent Sulfonyl-containing Antifolates

The Journal of biological chemistry, 2004-04, Vol.279 (17), p.18034-18045

2004

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Structure-based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase

The Journal of biological chemistry, 2007-04, Vol.282 (17), p.13033-13046

2007

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Sequence Alterations in the Reduced Folate Carrier Are Observed in Osteosarcoma Tumor Samples

Clinical cancer research, 2003-02, Vol.9 (2), p.837-844

2003

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Expression of HER2/erbB-2 Correlates With Survival in Osteosarcoma

Journal of clinical oncology, 1999-09, Vol.17 (9), p.2781-2788

1999

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Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis

Nature structural & molecular biology, 2001-05, Vol.8 (5), p.402-406

2001

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Catalytic Mechanism of the Cyclohydrolase Activity of Human Aminoimidazole Carboxamide Ribonucleotide Formyltransferase/Inosine Monophosphate Cyclohydrolase

Biochemistry (Easton), 2004-02, Vol.43 (5), p.1184-1192

2004

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The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling

The Journal of biological chemistry, 2002-06, Vol.277 (25), p.22168-22174

2002

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Structural Insights into the Avian AICAR Transformylase Mechanism

Biochemistry (Easton), 2002-12, Vol.41 (52), p.15505-15513

2002

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Crystal Structures of Human GAR Tfase at Low and High pH and with Substrate β-GAR

Biochemistry (Easton), 2002-12, Vol.41 (48), p.14206-14215

2002

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The Kinetic Mechanism of the Human Bifunctional Enzyme ATIC (5-Amino-4-imidazolecarboxamide Ribonucleotide Transformylase/Inosine 5′-Monophosphate Cyclohydrolase)

The Journal of biological chemistry, 2002-06, Vol.277 (25), p.22168-22174

2002

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10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-ddacthf) : A potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway

Bioorganic & medicinal chemistry, 2002-08, Vol.10 (8), p.2739-2749

2002

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LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes

Cancer research (Chicago, Ill.), 1997-03, Vol.57 (6), p.1116-1123

1997

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Synthesis of oligonucleotides containing 5-(hydroxymethyl)-2'-deoxyuridine at defined sites

Journal of organic chemistry, 1993-03, Vol.58 (7), p.1664-1665

1993

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Solution Structure of a DNA Dodecamer Containing the Anti-Neoplastic Agent Arabinosylcytosine: Combined Use of NMR, Restrained Molecular Dynamics, and Full Relaxation Matrix Refinement

Biochemistry (Easton), 1994-09, Vol.33 (38), p.11460-11475

1994

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Chiral Chemical Synthesis of DNA Containing (S)-9-(1,3-Dihydroxy-2-propoxymethyl)guanine (DHPG) and Effects on Thermal Stability, Duplex Structure, and Thermodynamics of Duplex Formation

Biochemistry (Easton), 1995-07, Vol.34 (28), p.9235-9248

1995

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Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin

Journal of medicinal chemistry, 1985-07, Vol.28 (7), p.914-921

1985

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Augmentation of fetal-hemoglobin production in anemic monkeys by hydroxyurea

The New England journal of medicine, 1984-04, Vol.310 (14), p.869-873

1984

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The Human purH Gene Product, 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase

The Journal of biological chemistry, 1996-01, Vol.271 (4), p.2225-2233

1996

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Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity

The Journal of biological chemistry, 2001-03, Vol.276 (11), p.7727-7733

2001

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(6R)-5,10-Dideaza-5,6,7,8-tetrahydrofolic acid effects on nucleotide metabolism in CCRF-CEM human T-lymphoblast leukemia cells

Cancer research (Chicago, Ill.), 1991-05, Vol.51 (9), p.2291-2295

1991

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The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping

The Journal of biological chemistry, 1996-01, Vol.271 (4), p.2225-2233

1996

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Functional consequences of the arabinosylcytosine structural lesion in DNA

Biochemistry (Easton), 1988-06, Vol.27 (13), p.4698-4705

1988

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Multifactorial resistance to 5,10-dideazatetrahydrofolic acid in cell lines derived from human lymphoblastic leukemia CCRF-CEM

Cancer research (Chicago, Ill.), 1995-02, Vol.55 (3), p.566-573

1995

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Mechanism of ganciclovir-induced chain termination revealed by resistant viral polymerase mutants with reduced exonuclease activity

Crystal Structures of Human Bifunctional Enzyme Aminoimidazole-4-carboxamide Ribonucleotide Transformylase/IMP Cyclohydrolase in Complex with Potent Sulfonyl-containing Antifolates

Structure-based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase

Sequence Alterations in the Reduced Folate Carrier Are Observed in Osteosarcoma Tumor Samples

Expression of HER2/erbB-2 Correlates With Survival in Osteosarcoma

Biology of childhood osteogenic sarcoma and potential targets for therapeutic development: Meeting summary

Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis

Catalytic Mechanism of the Cyclohydrolase Activity of Human Aminoimidazole Carboxamide Ribonucleotide Formyltransferase/Inosine Monophosphate Cyclohydrolase

The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling

Structural Insights into the Avian AICAR Transformylase Mechanism

Crystal Structures of Human GAR Tfase at Low and High pH and with Substrate β-GAR

The Kinetic Mechanism of the Human Bifunctional Enzyme ATIC (5-Amino-4-imidazolecarboxamide Ribonucleotide Transformylase/Inosine 5′-Monophosphate Cyclohydrolase)

10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-ddacthf) : A potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway

LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes

Synthesis of oligonucleotides containing 5-(hydroxymethyl)-2'-deoxyuridine at defined sites

Solution Structure of a DNA Dodecamer Containing the Anti-Neoplastic Agent Arabinosylcytosine: Combined Use of NMR, Restrained Molecular Dynamics, and Full Relaxation Matrix Refinement

Chiral Chemical Synthesis of DNA Containing (S)-9-(1,3-Dihydroxy-2-propoxymethyl)guanine (DHPG) and Effects on Thermal Stability, Duplex Structure, and Thermodynamics of Duplex Formation

Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin

Augmentation of fetal-hemoglobin production in anemic monkeys by hydroxyurea

The Human purH Gene Product, 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase

Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity

(6R)-5,10-Dideaza-5,6,7,8-tetrahydrofolic acid effects on nucleotide metabolism in CCRF-CEM human T-lymphoblast leukemia cells

The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping

Functional consequences of the arabinosylcytosine structural lesion in DNA

Multifactorial resistance to 5,10-dideazatetrahydrofolic acid in cell lines derived from human lymphoblastic leukemia CCRF-CEM

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