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Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy

International journal of molecular sciences, 2020-06, Vol.21 (11), p.3913

2020

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Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S‑2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures

Journal of medicinal chemistry, 2015-02, Vol.58 (4), p.1776-1794

2015

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Synthesis and Pharmacological Characterization of C4‑(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)‑2-Amino-4-(1H‑1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist

Journal of medicinal chemistry, 2015-09, Vol.58 (18), p.7526-7548

2015

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Chromenones as Multineurotargeting Inhibitors of Human Enzymes

ACS omega, 2019-12, Vol.4 (26), p.22161-22168

2019

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Synthesis and Pharmacological Characterization of 2‑(2,6-Dichlorophenyl)-1-((1S,3R)‑5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)‑yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor

Journal of medicinal chemistry, 2019-10, Vol.62 (19), p.8711-8732

2019

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The Chemotype of Chromanones as a Privileged Scaffold for Multineurotarget Anti-Alzheimer Agents

ACS pharmacology & translational science, 2022-11, Vol.5 (11), p.1097-1108

2022

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1-Aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors

Bioorganic & medicinal chemistry letters, 2005-10, Vol.15 (20), p.4432-4437

2005

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1-Aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors

Bioorganic & medicinal chemistry letters, 2005-10, Vol.15 (20), p.4432-4437

2005

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Investigation of a Flexible Enantiospecific Approach to Aziridines

Journal of organic chemistry, 2008-02, Vol.73 (3), p.1128-1130

2008

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Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu[subscript 2] Receptor Agonist

Journal of medicinal chemistry, 2016-03, Vol.58 ((18) ; 09, 2015)

2016

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Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1 S ,2 S ,5 R ,6 S -2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures

Journal of medicinal chemistry, 2015-02, Vol.58 (4), p.1776-1794

2015

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Automated Synthesis of New Quinoxalinetacrines

ChemistrySelect (Weinheim), 2020-06, Vol.5 (21), p.6491-6493

2020

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Synthesis and Pharmacological Characterization of C 4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 R ,2 S ,4 R ,5 R ,6 R )-2-Amino-4-(1 H -1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu 2 Receptor Agonist

Journal of medicinal chemistry, 2015-09, Vol.58 (18), p.7526-7548

2015

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An Enantiospecific Approach to Triazolylalanine Derivatives

Synthesis (Stuttgart), 2009-01, Vol.2009 (1), p.133-137

2009

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1-Aryl-3,4-dihydro-1 H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors

Bioorganic & medicinal chemistry letters, 2005, Vol.15 (20), p.4432-4437

2005

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ChemInform Abstract: Investigation of a Flexible Enantiospecific Approach to Aziridines

ChemInform, 2008-05, Vol.39 (22), p.no-no

2008

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1-Aryl-3,4-dihydro-1H-quinolin-2-one Derivatives, Novel and Selective Norepinephrine Reuptake Inhibitors

ChemInform, 2006-01, Vol.37 (2), p.no-no

2006

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Physiological regulation of productivity and water use in Eucalyptus: a review

Forest ecology and management, 2004-05, Vol.193 (1), p.113-140

2004

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The Ecophysiology of Foliar Anthocyanin

The Botanical review, 2003-04, Vol.69 (2), p.149-161

2003

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Prolongation of definitive head and neck cancer radiotherapy: Survival impact and predisposing factors

Radiotherapy and oncology, 2021-03, Vol.156, p.201-208

2021

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Mechanical versus manual chest compressions in the treatment of in-hospital cardiac arrest patients in a non-shockable rhythm - a randomised controlled feasibility trial (COMPRESS-RCT)

Scandinavian journal of trauma, resuscitation and emergency medicine, 2018-08, Vol.26 (1), p.70-70, Article 70

2018

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Oropharynx Cancer

Current problems in cancer, 2012-11, Vol.36 (6), p.334-415

2012

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Leaf angle responds to nitrogen supply in eucalypt seedlings. Is it a photoprotective mechanism?

Tree physiology, 2006-06, Vol.26 (6), p.743-748

2006

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Chilling-dependent photoinhibition, nutrition and growth analysis of Eucalyptus nitens seedlings during establishment

Tree physiology, 2003-03, Vol.23 (4), p.217-226

2003

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Quantifying the effect of cumulative water stress on stomatal conductance of Eucalyptus globulus and Eucalyptus nitens: a phenomenological approach

Functional plant biology : FPB, 1999, Vol.26 (1), p.17

1999

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Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy

Chromenones as Multineurotargeting Inhibitors of Human Enzymes

The Chemotype of Chromanones as a Privileged Scaffold for Multineurotarget Anti-Alzheimer Agents

1-Aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors

1-Aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors

Investigation of a Flexible Enantiospecific Approach to Aziridines

Automated Synthesis of New Quinoxalinetacrines

An Enantiospecific Approach to Triazolylalanine Derivatives

1-Aryl-3,4-dihydro-1 H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors

ChemInform Abstract: Investigation of a Flexible Enantiospecific Approach to Aziridines

1-Aryl-3,4-dihydro-1H-quinolin-2-one Derivatives, Novel and Selective Norepinephrine Reuptake Inhibitors

Physiological regulation of productivity and water use in Eucalyptus: a review

The Ecophysiology of Foliar Anthocyanin

Prolongation of definitive head and neck cancer radiotherapy: Survival impact and predisposing factors

Mechanical versus manual chest compressions in the treatment of in-hospital cardiac arrest patients in a non-shockable rhythm - a randomised controlled feasibility trial (COMPRESS-RCT)

Oropharynx Cancer

Leaf angle responds to nitrogen supply in eucalypt seedlings. Is it a photoprotective mechanism?

Chilling-dependent photoinhibition, nutrition and growth analysis of Eucalyptus nitens seedlings during establishment

Quantifying the effect of cumulative water stress on stomatal conductance of Eucalyptus globulus and Eucalyptus nitens: a phenomenological approach

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