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Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells

PLoS computational biology, 2017-02, Vol.13 (2), p.e1005332-e1005332

2017

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Development of a minimal PBPK-QSP modeling platform for LNP-mRNA based therapeutics to study tissue disposition and protein expression dynamics

Frontiers in nanotechnology, 2024-01, Vol.6

2024

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Eliciting the antitumor immune response with a conditionally activated PD‐L1 targeting antibody analyzed with a quantitative systems pharmacology model

CPT: pharmacometrics and systems pharmacology, 2024-01, Vol.13 (1), p.93-105

2024

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Computer Simulation of TSP1 Inhibition of VEGF-Akt-eNOS: An Angiogenesis Triple Threat

Frontiers in physiology, 2018-05, Vol.9, p.644-644

2018

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A Mathematical Model of Electrotonic Interactions between Ventricular Myocytes and Fibroblasts

Biophysical journal, 2007-06, Vol.92 (11), p.4121-4132

2007

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Novel fluorescence resonance energy transfer‐based reporter reveals differential calcineurin activation in neonatal and adult cardiomyocytes

The Journal of physiology, 2015-09, Vol.593 (17), p.3865-3884

2015

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A mechanistic systems pharmacology modeling platform to investigate the effect of PD-L1 expression heterogeneity and dynamics on the efficacy of PD-1 and PD-L1 blocking antibodies in cancer

Journal of theoretical biology, 2021-08, Vol.522, p.110697-110697, Article 110697

2021

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Dynamic switching of calmodulin interactions underlies Ca2+ regulation of CaV1.3 channels

Nature communications, 2013-01, Vol.4 (1), p.1717-1717, Article 1717

2013

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Towards a Unified Theory of Calmodulin Regulation (Calmodulation) of Voltage-Gated Calcium and Sodium Channels

Current molecular pharmacology, 2015-01, Vol.8 (2), p.188

2015

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Computational investigation of sphingosine kinase 1

PLoS computational biology, 2017-02, Vol.13 (2)

2017

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Quantitative Translation in Immuno‐Oncology Research and Development

Clinical pharmacology and therapeutics, 2020-09, Vol.108 (3), p.430-433

2020

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Continuously Tunable Ca2+ Regulation of RNA-Edited CaV1.3 Channels

Cell reports (Cambridge), 2013-10, Vol.5 (2), p.367-377

2013

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Computational modeling of synergistic interaction between αVβ3 integrin and VEGFR2 in endothelial cells: Implications for the mechanism of action of angiogenesis-modulating integrin-binding peptides

Journal of theoretical biology, 2018-10, Vol.455, p.212-221

2018

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Combining Multikinase Tyrosine Kinase Inhibitors Targeting the Vascular Endothelial Growth Factor and Cluster of Differentiation 47 Signaling Pathways Is Predicted to Increase the Efficacy of Antiangiogenic Combination Therapies

ACS pharmacology & translational science, 2023-05, Vol.6 (5), p.710-726

2023

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Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation

Frontiers in physiology, 2017-02, Vol.8, p.48-48

2017

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Three-Dimensional Transport Model for Intravitreal and Suprachoroidal Drug Injection

Investigative ophthalmology & visual science, 2018-10, Vol.59 (12), p.5266-5276

2018

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Biomimetic peptide display from a polymeric nanoparticle surface for targeting and antitumor activity to human triple‐negative breast cancer cells

Journal of biomedical materials research. Part A, 2018-06, Vol.106 (6), p.1753-1764

2018

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FRET-Based Genetically Encoded Sensor of Calcineurin Activation

Biophysical journal, 2013-01, Vol.104 (2), p.530a-530a

2013

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Continuously tunable Ca(2+) regulation of RNA-edited CaV1.3 channels

Cell reports (Cambridge), 2013-10, Vol.5 (2), p.367-377

2013

Volltextzugriff (PDF)

Corrigendum: Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation

Frontiers in physiology, 2017-03, Vol.8, p.147-147

2017

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Resolving the Grip of the Distal Carboxy Tail on the Proximal Calmodulatory Region of CaV Channels

Biophysical journal, 2012-01, Vol.102 (3), p.126a-126a

2012

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Departure of Calmodulin from the IQ Domain of CaV1.3 Channels During Calcium-Dependent Inactivation

Biophysical journal, 2011-02, Vol.100 (3), p.571

2011

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TAK-676: A Novel Stimulator of Interferon Genes (STING) Agonist Promoting Durable IFN-dependent Antitumor Immunity in Preclinical Studies

Cancer research communications, 2022-06, Vol.2 (6), p.489-502

2022

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Departure of Calmodulin from the IQ Domain of Ca V1.3 Channels During Calcium-Dependent Inactivation

Biophysical journal, 2011, Vol.100 (3), p.571a-571a

2011

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Calmodulin Release from the IQ Domain of Cav1.3 Channels During Calcium Dependent Inactivation?

Biophysical journal, 2010-01, Vol.98 (3), p.519a-519a

2010

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Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells

Development of a minimal PBPK-QSP modeling platform for LNP-mRNA based therapeutics to study tissue disposition and protein expression dynamics

Eliciting the antitumor immune response with a conditionally activated PD‐L1 targeting antibody analyzed with a quantitative systems pharmacology model

Computer Simulation of TSP1 Inhibition of VEGF-Akt-eNOS: An Angiogenesis Triple Threat

A Mathematical Model of Electrotonic Interactions between Ventricular Myocytes and Fibroblasts

Novel fluorescence resonance energy transfer‐based reporter reveals differential calcineurin activation in neonatal and adult cardiomyocytes

A mechanistic systems pharmacology modeling platform to investigate the effect of PD-L1 expression heterogeneity and dynamics on the efficacy of PD-1 and PD-L1 blocking antibodies in cancer

Dynamic switching of calmodulin interactions underlies Ca2+ regulation of CaV1.3 channels

Towards a Unified Theory of Calmodulin Regulation (Calmodulation) of Voltage-Gated Calcium and Sodium Channels

Computational investigation of sphingosine kinase 1

Quantitative Translation in Immuno‐Oncology Research and Development

Continuously Tunable Ca2+ Regulation of RNA-Edited CaV1.3 Channels

Computational modeling of synergistic interaction between αVβ3 integrin and VEGFR2 in endothelial cells: Implications for the mechanism of action of angiogenesis-modulating integrin-binding peptides

Combining Multikinase Tyrosine Kinase Inhibitors Targeting the Vascular Endothelial Growth Factor and Cluster of Differentiation 47 Signaling Pathways Is Predicted to Increase the Efficacy of Antiangiogenic Combination Therapies

Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation

Three-Dimensional Transport Model for Intravitreal and Suprachoroidal Drug Injection

Biomimetic peptide display from a polymeric nanoparticle surface for targeting and antitumor activity to human triple‐negative breast cancer cells

FRET-Based Genetically Encoded Sensor of Calcineurin Activation

Continuously tunable Ca(2+) regulation of RNA-edited CaV1.3 channels

Corrigendum: Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation

Resolving the Grip of the Distal Carboxy Tail on the Proximal Calmodulatory Region of CaV Channels

Departure of Calmodulin from the IQ Domain of CaV1.3 Channels During Calcium-Dependent Inactivation

TAK-676: A Novel Stimulator of Interferon Genes (STING) Agonist Promoting Durable IFN-dependent Antitumor Immunity in Preclinical Studies

Departure of Calmodulin from the IQ Domain of Ca V1.3 Channels During Calcium-Dependent Inactivation

Calmodulin Release from the IQ Domain of Cav1.3 Channels During Calcium Dependent Inactivation?

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