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Drug Development Targeting the Ubiquitin-Proteasome System (UPS) for the Treatment of Human Cancers

Cancers, 2020-04, Vol.12 (4), p.902

2020

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Deubiquitinating Enzymes in Coronaviruses and Possible Therapeutic Opportunities for COVID-19

International journal of molecular sciences, 2020-05, Vol.21 (10), p.3492

2020

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Targeting Mitochondria for Treatment of Chemoresistant Ovarian Cancer

International journal of molecular sciences, 2019-01, Vol.20 (1), p.229

2019

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The DNA Cytosine Deaminase APOBEC3B is a Molecular Determinant of Platinum Responsiveness in Clear Cell Ovarian Cancer

Clinical cancer research, 2020-07, Vol.26 (13), p.3397-3407

2020

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Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries

International journal of molecular sciences, 2021-04, Vol.22 (9), p.4750

2021

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The Ovary-Brain Connection

Cells (Basel, Switzerland), 2024-01, Vol.13 (1), p.94

2024

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Small-Molecule RA-9 Inhibits Proteasome-Associated DUBs and Ovarian Cancer In Vitro and In Vivo via Exacerbating Unfolded Protein Responses

Clinical cancer research, 2014-06, Vol.20 (12), p.3174-3186

2014

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Abstract A41: Ovarian cancer as an infectious disease. Targeting of mitochondrial activity to prevent and treat recurrent ovarian cancer

Clinical cancer research, 2018-08, Vol.24 (15_Supplement), p.A41-A41

Bazzaro, Martina

2018

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Combination of Proteasome and HDAC Inhibitors for Uterine Cervical Cancer Treatment

Clinical cancer research, 2009-01, Vol.15 (2), p.570-577

2009

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Simultaneous inhibition of deubiquitinating enzymes (DUBs) and autophagy synergistically kills breast cancer cells

Oncotarget, 2015-02, Vol.6 (6), p.4159-4170

2015

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USP14 is a predictor of recurrence in endometrial cancer and a molecular target for endometrial cancer treatment

Oncotarget, 2016-05, Vol.7 (21), p.30962-30976

2016

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UNC-45A Is Highly Expressed in the Proliferative Cells of the Mouse Genital Tract and in the Microtubule-Rich Areas of the Mouse Nervous System

Cells (Basel, Switzerland), 2021-06, Vol.10 (7), p.1604

2021

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Ubiquitin Proteasome System Stress Underlies Synergistic Killing of Ovarian Cancer Cells by Bortezomib and a Novel HDAC6 Inhibitor

Clinical cancer research, 2008-11, Vol.14 (22), p.7340-7347

2008

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Cellular and Molecular Networking Within the Ecosystem of Cancer Cell Communication via Tunneling Nanotubes

Frontiers in cell and developmental biology, 2018-10, Vol.6, p.95-95

2018

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Stressing the ubiquitin-proteasome system without 20S proteolytic inhibition selectively kills cervical cancer cells

PloS one, 2011-08, Vol.6 (8), p.e23888

2011

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Ubiquitin-proteasome system stress sensitizes ovarian cancer to proteasome inhibitor-induced apoptosis

Cancer research (Chicago, Ill.), 2006-04, Vol.66 (7), p.3754-3763

2006

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Establishment, characterization and downstream application of primary ovarian cancer cells derived from solid tumors

PloS one, 2012-11, Vol.7 (11), p.e50519-e50519

2012

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Dienone Compounds: Targets and Pharmacological Responses

Journal of medicinal chemistry, 2020-12, Vol.63 (24), p.15075-15093

2020

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Targeting Deubiquitinating Enzymes and Autophagy in Cancer

Methods in molecular biology (Clifton, N.J.), 2017-01, Vol.1513, p.49

2017

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The microtubule-severing protein UNC-45A preferentially binds to curved microtubules and counteracts the microtubule-straightening effects of Taxol

The Journal of biological chemistry, 2023-11, Vol.299 (11), p.105355, Article 105355

2023

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UNC-45A breaks the microtubule lattice independently of its effects on non-muscle myosin II

Journal of cell science, 2021-01, Vol.134 (1)

2021

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Measurement of deubiquitinating enzyme activity via a suicidal HA-Ub-VS probe

Methods in molecular biology (Clifton, N.J.), 2015, Vol.1249, p.193

2015

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Single cell sequencing reveals heterogeneity within ovarian cancer epithelium and cancer associated stromal cells

Gynecologic oncology, 2017-03, Vol.144 (3), p.598-606

2017

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UNC-45A Breaks MT Lattice Independent of its Effect on Non-Muscle Myosin II

Journal of cell science, 2020-01

2020

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UNC-45A Is a Novel Microtubule-Associated Protein and Regulator of Paclitaxel Sensitivity in Ovarian Cancer Cells

Molecular cancer research, 2019-02, Vol.17 (2), p.370-383

2019

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Drug Development Targeting the Ubiquitin-Proteasome System (UPS) for the Treatment of Human Cancers

Deubiquitinating Enzymes in Coronaviruses and Possible Therapeutic Opportunities for COVID-19

Targeting Mitochondria for Treatment of Chemoresistant Ovarian Cancer

The DNA Cytosine Deaminase APOBEC3B is a Molecular Determinant of Platinum Responsiveness in Clear Cell Ovarian Cancer

Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries

The Ovary-Brain Connection

Small-Molecule RA-9 Inhibits Proteasome-Associated DUBs and Ovarian Cancer In Vitro and In Vivo via Exacerbating Unfolded Protein Responses

Abstract A41: Ovarian cancer as an infectious disease. Targeting of mitochondrial activity to prevent and treat recurrent ovarian cancer

Combination of Proteasome and HDAC Inhibitors for Uterine Cervical Cancer Treatment

Simultaneous inhibition of deubiquitinating enzymes (DUBs) and autophagy synergistically kills breast cancer cells

USP14 is a predictor of recurrence in endometrial cancer and a molecular target for endometrial cancer treatment

UNC-45A Is Highly Expressed in the Proliferative Cells of the Mouse Genital Tract and in the Microtubule-Rich Areas of the Mouse Nervous System

Ubiquitin Proteasome System Stress Underlies Synergistic Killing of Ovarian Cancer Cells by Bortezomib and a Novel HDAC6 Inhibitor

Cellular and Molecular Networking Within the Ecosystem of Cancer Cell Communication via Tunneling Nanotubes

Stressing the ubiquitin-proteasome system without 20S proteolytic inhibition selectively kills cervical cancer cells

Ubiquitin-proteasome system stress sensitizes ovarian cancer to proteasome inhibitor-induced apoptosis

Establishment, characterization and downstream application of primary ovarian cancer cells derived from solid tumors

Dienone Compounds: Targets and Pharmacological Responses

Targeting Deubiquitinating Enzymes and Autophagy in Cancer

The microtubule-severing protein UNC-45A preferentially binds to curved microtubules and counteracts the microtubule-straightening effects of Taxol

UNC-45A breaks the microtubule lattice independently of its effects on non-muscle myosin II

Measurement of deubiquitinating enzyme activity via a suicidal HA-Ub-VS probe

Single cell sequencing reveals heterogeneity within ovarian cancer epithelium and cancer associated stromal cells

UNC-45A Breaks MT Lattice Independent of its Effect on Non-Muscle Myosin II

UNC-45A Is a Novel Microtubule-Associated Protein and Regulator of Paclitaxel Sensitivity in Ovarian Cancer Cells

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