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Constitutively active MyD88/CD40 costimulation enhances expansion and efficacy of chimeric antigen receptor T cells targeting hematological malignancies

Leukemia, 2019-09, Vol.33 (9), p.2195-2207

2019

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Inducible MyD88/CD40 synergizes with IL-15 to enhance antitumor efficacy of CAR-NK cells

Blood advances, 2020-05, Vol.4 (9), p.1950-1964

2020

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Endocardial Brg1 Represses ADAMTS1 to Maintain the Microenvironment for Myocardial Morphogenesis

Developmental cell, 2008-02, Vol.14 (2), p.298-311

2008

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Two-Dimensional Regulation of CAR-T Cell Therapy with Orthogonal Switches

Molecular therapy. Oncolytics, 2019-03, Vol.12, p.124-137

2019

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Ligands for FKBP12 Increase Ca2+ Influx and Protein Synthesis to Improve Skeletal Muscle Function

The Journal of biological chemistry, 2014-09, Vol.289 (37), p.25556-25570

2014

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Engineering Tolerance toward Allogeneic CAR-T Cells by Regulation of MHC Surface Expression with Human Herpes Virus-8 Proteins

Molecular therapy, 2021-02, Vol.29 (2), p.718-733

2021

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Regulated Expansion and Survival of Chimeric Antigen Receptor-Modified T Cells Using Small Molecule-Dependent Inducible MyD88/CD40

Molecular therapy, 2017-09, Vol.25 (9), p.2176-2188

2017

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A Field of Myocardial-Endocardial NFAT Signaling Underlies Heart Valve Morphogenesis

Cell, 2004-09, Vol.118 (5), p.649-663

2004

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Conditional Protein Alleles Using Knockin Mice and a Chemical Inducer of Dimerization

Molecular cell, 2003-12, Vol.12 (6), p.1615-1624

2003

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Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acids

Molecular and Cellular Biology, 1995-01, Vol.15 (1), p.497-504

1995

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Hyperphenylalaninemia and Impaired Glucose Tolerance in Mice Lacking the Bifunctional DCoH Gene

The Journal of biological chemistry, 2002-08, Vol.277 (32), p.28884-28891

2002

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Rescue of Degradation-Prone Mutants of the FK506-Rapamycin Binding (FRB) Protein with Chemical Ligands

Chembiochem : a European journal of chemical biology, 2007-07, Vol.8 (10), p.1162-1169

2007

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Sudden Infant Death Syndrome in Mice With an Inherited Mutation in RyR2

Circulation. Arrhythmia and electrophysiology, 2009-12, Vol.2 (6), p.677-685

2009

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Abstract 2193: Small molecule inducible MyD88/CD40 (iMC) in CAR-T cells can repolarize M2 macrophage to an anti-tumor M1 phenotype

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.2193-2193

2020

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Biochemical and Structural Basis for Partially Redundant Enzymatic and Transcriptional Functions of DCoH and DCoH2

Biochemistry (Easton), 2004-06, Vol.43 (23), p.7345-7355

2004

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The Carboxyl-Terminal Domain of the p53 Protein Regulates Sequence-Specific DNA Binding through Its Nonspecific Nucleic Acid-Binding Activity

Proceedings of the National Academy of Sciences - PNAS, 1995-06, Vol.92 (12), p.5729-5733

1995

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Abstract 2194: Inducible MyD88/CD40 (iMC) enhances CAR-T cell expansion and persistence by overcoming T cell exhaustion

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.2194-2194

2020

Volltextzugriff (PDF)

Preclinical Development of Inducible MyD88/CD40 (iMC)-Enhanced Chimeric Antigen Receptor Natural Killer (GoCAR-NK) Cells to Target BCMA+ Tumors

Blood, 2020-11, Vol.136 (Supplement 1), p.39-40

2020

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Abstract LB-141: A unified dual-switch CAR vector to target solid cancer with controllable "on" and "off" states

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.LB-141-LB-141

2018

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Regulated Natural Killer Cell Expansion and Anti-Tumor Activity with Inducible MyD88/CD40

Blood, 2018-11, Vol.132 (Supplement 1), p.4550-4550

2018

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Abstract LB-184: Dual-switchGoCAR-T cells: small molecule-regulated “GO” and “STOP” switches to target solid cancer in vivo

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.LB-184-LB-184

2017

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Inducible MyD88/CD40 (iMC) Costimulation Provides Ligand-Dependent Tumor Eradication By CD123-Specific Chimeric Antigen Receptor T Cells

Blood, 2016-12, Vol.128 (22), p.4551-4551

2016

Volltextzugriff (PDF)

Dual-Switch CAR-T Cells: Orthogonal Molecular Switches to Control Activation and Elimination of CAR-T Cells to Target CD123+ Cancer

Blood, 2017-12, Vol.130, p.3184-3184

2017

Volltextzugriff (PDF)

Abstract 3745: Dual-switch TCR: A two-ligand system to control PRAME TCR-modified T cell proliferation and death using inducible MyD88/CD40 and caspase-9

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.3745-3745

2017

Volltextzugriff (PDF)

The p53-mdm-2 autoregulatory feedback loop

Genes & development, 1993-07, Vol.7 (7A), p.1126-1132

1993

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Constitutively active MyD88/CD40 costimulation enhances expansion and efficacy of chimeric antigen receptor T cells targeting hematological malignancies

Inducible MyD88/CD40 synergizes with IL-15 to enhance antitumor efficacy of CAR-NK cells

Endocardial Brg1 Represses ADAMTS1 to Maintain the Microenvironment for Myocardial Morphogenesis

Two-Dimensional Regulation of CAR-T Cell Therapy with Orthogonal Switches

Ligands for FKBP12 Increase Ca2+ Influx and Protein Synthesis to Improve Skeletal Muscle Function

Engineering Tolerance toward Allogeneic CAR-T Cells by Regulation of MHC Surface Expression with Human Herpes Virus-8 Proteins

Regulated Expansion and Survival of Chimeric Antigen Receptor-Modified T Cells Using Small Molecule-Dependent Inducible MyD88/CD40

A Field of Myocardial-Endocardial NFAT Signaling Underlies Heart Valve Morphogenesis

Conditional Protein Alleles Using Knockin Mice and a Chemical Inducer of Dimerization

Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acids

Hyperphenylalaninemia and Impaired Glucose Tolerance in Mice Lacking the Bifunctional DCoH Gene

Rescue of Degradation-Prone Mutants of the FK506-Rapamycin Binding (FRB) Protein with Chemical Ligands

Sudden Infant Death Syndrome in Mice With an Inherited Mutation in RyR2

Abstract 2193: Small molecule inducible MyD88/CD40 (iMC) in CAR-T cells can repolarize M2 macrophage to an anti-tumor M1 phenotype

Biochemical and Structural Basis for Partially Redundant Enzymatic and Transcriptional Functions of DCoH and DCoH2

The Carboxyl-Terminal Domain of the p53 Protein Regulates Sequence-Specific DNA Binding through Its Nonspecific Nucleic Acid-Binding Activity

Abstract 2194: Inducible MyD88/CD40 (iMC) enhances CAR-T cell expansion and persistence by overcoming T cell exhaustion

Preclinical Development of Inducible MyD88/CD40 (iMC)-Enhanced Chimeric Antigen Receptor Natural Killer (GoCAR-NK) Cells to Target BCMA+ Tumors

Abstract LB-141: A unified dual-switch CAR vector to target solid cancer with controllable "on" and "off" states

Regulated Natural Killer Cell Expansion and Anti-Tumor Activity with Inducible MyD88/CD40

Abstract LB-184: Dual-switchGoCAR-T cells: small molecule-regulated “GO” and “STOP” switches to target solid cancer in vivo

Inducible MyD88/CD40 (iMC) Costimulation Provides Ligand-Dependent Tumor Eradication By CD123-Specific Chimeric Antigen Receptor T Cells

Dual-Switch CAR-T Cells: Orthogonal Molecular Switches to Control Activation and Elimination of CAR-T Cells to Target CD123+ Cancer

Abstract 3745: Dual-switch TCR: A two-ligand system to control PRAME TCR-modified T cell proliferation and death using inducible MyD88/CD40 and caspase-9

The p53-mdm-2 autoregulatory feedback loop

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