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Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism

Structure (London), 2016-11, Vol.24 (11), p.1863-1875

2016

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DNA polymerase structure-based insight on the mutagenic properties of 8-oxoguanine

Mutation research, 2010-11, Vol.703 (1), p.18-23

2010

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Magnesium-Induced Assembly of a Complete DNA Polymerase Catalytic Complex

Structure (London), 2006-04, Vol.14 (4), p.757-766

2006

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Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion

Proceedings of the National Academy of Sciences - PNAS, 2012-01, Vol.109 (1), p.113-118

2012

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Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site

Nature structural & molecular biology, 2010-07, Vol.17 (7), p.889-890

2010

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Energy Analysis of Chemistry for Correct Insertion by DNA Polymerase β

Proceedings of the National Academy of Sciences - PNAS, 2006-09, Vol.103 (36), p.13294-13299

2006

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Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase β

Proceedings of the National Academy of Sciences - PNAS, 2008-04, Vol.105 (15), p.5670-5674

2008

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Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid

Proceedings of the National Academy of Sciences - PNAS, 2010-09, Vol.107 (36), p.15693-15698

2010

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Molecular basis for the faithful replication of 5-methylcytosine and its oxidized forms by DNA polymerase β

The Journal of biological chemistry, 2019-05, Vol.294 (18), p.7194-7201

2019

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DNA polymerase β nucleotide-stabilized template misalignment fidelity depends on local sequence context

The Journal of biological chemistry, 2020-01, Vol.295 (2), p.529-538

2020

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Role of polymerase β in complementing aprataxin deficiency during abasic-site base excision repair

Nature structural & molecular biology, 2014-05, Vol.21 (5), p.497-499

2014

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Revealing an Internal Stabilization Deficiency in the DNA Polymerase β K289M Cancer Variant through the Combined Use of Chemical Biology and X‑ray Crystallography

Biochemistry (Easton), 2020-03, Vol.59 (8), p.955-963

2020

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Mapping Functional Substrate–Enzyme Interactions in the pol β Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs

Biochemistry (Easton), 2018-07, Vol.57 (26), p.3934-3944

2018

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Probing DNA Base-Dependent Leaving Group Kinetic Effects on the DNA Polymerase Transition State

Biochemistry (Easton), 2018-07, Vol.57 (26), p.3925-3933

2018

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Substrate-induced DNA Polymerase β Activation

The Journal of biological chemistry, 2014-11, Vol.289 (45), p.31411-31422

2014

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Structures of DNA Polymerase β with Active-Site Mismatches Suggest a Transient Abasic Site Intermediate during Misincorporation

Molecular cell, 2008-05, Vol.30 (3), p.315-324

2008

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Amino Acid Substitution in the Active Site of DNA Polymerase β Explains the Energy Barrier of the Nucleotidyl Transfer Reaction

Journal of the American Chemical Society, 2013-05, Vol.135 (21), p.8078-8088

2013

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The X family portrait: Structural insights into biological functions of X family polymerases

DNA repair, 2007-12, Vol.6 (12), p.1709-1725

2007

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Structure of a DNA polymerase abortive complex with the 8OG:dA base pair at the primer terminus

Communications biology, 2020-07, Vol.3 (1), p.348, Article 348

2020

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Molecular Insights into DNA Polymerase Deterrents for Ribonucleotide Insertion

The Journal of biological chemistry, 2011-09, Vol.286 (36), p.31650-31660

2011

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DNA polymerase beta substrate specificity: side chain modulation of the "A-rule"

The Journal of biological chemistry, 2009-11, Vol.284 (46), p.31680-31689

2009

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Two Scaffolds from Two Flips: (α,β)/(β,γ) CH2/NH “Met-Im” Analogues of dTTP

Organic letters, 2015-06, Vol.17 (11), p.2586-2589

2015

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Structure of DNA Polymerase β with a Benzo[c]phenanthrene Diol Epoxide-Adducted Template Exhibits Mutagenic Features

Proceedings of the National Academy of Sciences - PNAS, 2006-11, Vol.103 (46), p.17231-17236

2006

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Halogenated β,γ-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase β: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues

Journal of the American Chemical Society, 2010-06, Vol.132 (22), p.7617-7625

2010

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Modifying the β,γ Leaving-Group Bridging Oxygen Alters Nucleotide Incorporation Efficiency, Fidelity, and the Catalytic Mechanism of DNA Polymerase β

Biochemistry (Easton), 2007-01, Vol.46 (2), p.461-471

2007

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Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism

DNA polymerase structure-based insight on the mutagenic properties of 8-oxoguanine

Magnesium-Induced Assembly of a Complete DNA Polymerase Catalytic Complex

Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion

Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site

Energy Analysis of Chemistry for Correct Insertion by DNA Polymerase β

Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase β

Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid

Molecular basis for the faithful replication of 5-methylcytosine and its oxidized forms by DNA polymerase β

DNA polymerase β nucleotide-stabilized template misalignment fidelity depends on local sequence context

Role of polymerase β in complementing aprataxin deficiency during abasic-site base excision repair

Revealing an Internal Stabilization Deficiency in the DNA Polymerase β K289M Cancer Variant through the Combined Use of Chemical Biology and X‑ray Crystallography

Mapping Functional Substrate–Enzyme Interactions in the pol β Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs

Probing DNA Base-Dependent Leaving Group Kinetic Effects on the DNA Polymerase Transition State

Substrate-induced DNA Polymerase β Activation

Structures of DNA Polymerase β with Active-Site Mismatches Suggest a Transient Abasic Site Intermediate during Misincorporation

Amino Acid Substitution in the Active Site of DNA Polymerase β Explains the Energy Barrier of the Nucleotidyl Transfer Reaction

The X family portrait: Structural insights into biological functions of X family polymerases

Structure of a DNA polymerase abortive complex with the 8OG:dA base pair at the primer terminus

Molecular Insights into DNA Polymerase Deterrents for Ribonucleotide Insertion

DNA polymerase beta substrate specificity: side chain modulation of the "A-rule"

Two Scaffolds from Two Flips: (α,β)/(β,γ) CH2/NH “Met-Im” Analogues of dTTP

Structure of DNA Polymerase β with a Benzo[c]phenanthrene Diol Epoxide-Adducted Template Exhibits Mutagenic Features

Halogenated β,γ-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase β: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues

Modifying the β,γ Leaving-Group Bridging Oxygen Alters Nucleotide Incorporation Efficiency, Fidelity, and the Catalytic Mechanism of DNA Polymerase β

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