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Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4)

Nature communications, 2023-01, Vol.14 (1), p.492-492, Article 492

2023

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Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS

PloS one, 2012-08, Vol.7 (8), p.e42714-e42714

2012

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Relaxin family peptides: structure–activity relationship studies

British journal of pharmacology, 2017-05, Vol.174 (10), p.950-961

2017

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International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides

Pharmacological reviews, 2015-04, Vol.67 (2), p.389-440

2015

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Further Developments towards a Minimal Potent Derivative of Human Relaxin-2

International journal of molecular sciences, 2023-08, Vol.24 (16), p.12670

2023

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Stabilization of pre-existing neurotensin receptor conformational states by β-arrestin-1 and the biased allosteric modulator ML314

Nature communications, 2023-06, Vol.14 (1), p.3328-14, Article 3328

2023

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Unravelling the mechanism of neurotensin recognition by neurotensin receptor 1

Nature communications, 2023-12, Vol.14 (1), p.8155-8155, Article 8155

2023

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A Novel Ultra-Stable, Monomeric Green Fluorescent Protein For Direct Volumetric Imaging of Whole Organs Using CLARITY

Scientific reports, 2018-01, Vol.8 (1), p.667-15, Article 667

2018

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A Lipidated Single-B-Chain Derivative of Relaxin Exhibits Improved In Vitro Serum Stability without Altering Activity

International journal of molecular sciences, 2023-04, Vol.24 (7), p.6616

2023

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A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

Chemical science (Cambridge), 2016-01, Vol.7 (6), p.3805-3819

2016

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Cardiovascular effects of relaxin: from basic science to clinical therapy

Nature reviews cardiology, 2010-01, Vol.7 (1), p.48-58

2010

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Chronic activation of the relaxin‐3 receptor on GABA neurons in rat ventral hippocampus promotes anxiety and social avoidance

Hippocampus, 2019-10, Vol.29 (10), p.905-920

2019

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The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1

Nature communications, 2016-04, Vol.7 (1), p.11344-11344, Article 11344

2016

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High-Throughput Screening Campaign Identified a Potential Small Molecule RXFP3/4 Agonist

Molecules (Basel, Switzerland), 2021-12, Vol.26 (24), p.7511

2021

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ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

Scientific reports, 2017-06, Vol.7 (1), p.2968-14, Article 2968

2017

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Design, Synthesis, and Characterization of a Single-Chain Peptide Antagonist for the Relaxin-3 Receptor RXFP3

Journal of the American Chemical Society, 2011-04, Vol.133 (13), p.4965-4974

2011

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Selective transduction and photoinhibition of pre-Bötzinger complex neurons that project to the facial nucleus in rats affects nasofacial activity

eLife, 2023-09, Vol.12

2023

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Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production

Proceedings of the National Academy of Sciences - PNAS, 2013-04, Vol.110 (15), p.E1426-E1435

2013

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The Different Ligand-Binding Modes of Relaxin Family Peptide Receptors RXFP1 and RXFP2

Molecular endocrinology (Baltimore, Md.), 2012-11, Vol.26 (11), p.1896-1906

2012

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A Real-Time, Plate-Based BRET Assay for Detection of cGMP in Primary Cells

International journal of molecular sciences, 2022-02, Vol.23 (3), p.1908

2022

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Relaxin Modulates Cardiac Fibroblast Proliferation, Differentiation, and Collagen Production and Reverses Cardiac Fibrosis in Vivo

Endocrinology (Philadelphia), 2004-09, Vol.145 (9), p.4125-4133

2004

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Signal transduction pathways activated by insulin‐like peptide 5 at the relaxin family peptide RXFP4 receptor

British journal of pharmacology, 2017-05, Vol.174 (10), p.1077-1089

2017

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Structure and Function Relationship of Murine Insulin-like Peptide 5 (INSL5): Free C-Terminus Is Essential for RXFP4 Receptor Binding and Activation

Biochemistry (Easton), 2011-10, Vol.50 (39), p.8352-8361

2011

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Determinants of Ligand Subtype-Selectivity at α1A-Adrenoceptor Revealed Using Saturation Transfer Difference (STD) NMR

ACS chemical biology, 2018-04, Vol.13 (4), p.1090-1102

2018

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Nucleus incertus promotes cortical desynchronization and behavioral arousal

Brain Structure and Function, 2017, Vol.222 (1), p.515-537

2017

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Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4)

Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS

Relaxin family peptides: structure–activity relationship studies

International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides

Further Developments towards a Minimal Potent Derivative of Human Relaxin-2

Stabilization of pre-existing neurotensin receptor conformational states by β-arrestin-1 and the biased allosteric modulator ML314

Unravelling the mechanism of neurotensin recognition by neurotensin receptor 1

A Novel Ultra-Stable, Monomeric Green Fluorescent Protein For Direct Volumetric Imaging of Whole Organs Using CLARITY

A Lipidated Single-B-Chain Derivative of Relaxin Exhibits Improved In Vitro Serum Stability without Altering Activity

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

Cardiovascular effects of relaxin: from basic science to clinical therapy

Chronic activation of the relaxin‐3 receptor on GABA neurons in rat ventral hippocampus promotes anxiety and social avoidance

The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1

High-Throughput Screening Campaign Identified a Potential Small Molecule RXFP3/4 Agonist

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

Design, Synthesis, and Characterization of a Single-Chain Peptide Antagonist for the Relaxin-3 Receptor RXFP3

Selective transduction and photoinhibition of pre-Bötzinger complex neurons that project to the facial nucleus in rats affects nasofacial activity

Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production

The Different Ligand-Binding Modes of Relaxin Family Peptide Receptors RXFP1 and RXFP2

A Real-Time, Plate-Based BRET Assay for Detection of cGMP in Primary Cells

Relaxin Modulates Cardiac Fibroblast Proliferation, Differentiation, and Collagen Production and Reverses Cardiac Fibrosis in Vivo

Signal transduction pathways activated by insulin‐like peptide 5 at the relaxin family peptide RXFP4 receptor

Structure and Function Relationship of Murine Insulin-like Peptide 5 (INSL5): Free C-Terminus Is Essential for RXFP4 Receptor Binding and Activation

Determinants of Ligand Subtype-Selectivity at α1A-Adrenoceptor Revealed Using Saturation Transfer Difference (STD) NMR

Nucleus incertus promotes cortical desynchronization and behavioral arousal

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