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Genetically engineered human cortical spheroid models of tuberous sclerosis

Nature medicine, 2018-10, Vol.24 (10), p.1568-1578

2018

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Excitatory/Inhibitory Synaptic Imbalance Leads to Hippocampal Hyperexcitability in Mouse Models of Tuberous Sclerosis

Neuron (Cambridge, Mass.), 2013-05, Vol.78 (3), p.510-522

2013

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Dopaminergic Dysregulation in Syndromic Autism Spectrum Disorders: Insights From Genetic Mouse Models

Frontiers in neural circuits, 2021-07, Vol.15, p.700968-700968

2021

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Raptor downregulation rescues neuronal phenotypes in mouse models of Tuberous Sclerosis Complex

Nature communications, 2022-08, Vol.13 (1), p.4665-4665, Article 4665

2022

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Global Transcriptional and Translational Repression in Human-Embryonic-Stem-Cell-Derived Rett Syndrome Neurons

Cell stem cell, 2013-10, Vol.13 (4), p.446-458

2013

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Interferon-independent STING signaling promotes resistance to HSV-1 in vivo

Nature communications, 2020-07, Vol.11 (1), p.3382-3382, Article 3382

2020

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Widespread Translational Remodeling during Human Neuronal Differentiation

Cell reports (Cambridge), 2017-11, Vol.21 (7), p.2005-2016

2017

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Altered motor learning and coordination in mouse models of autism spectrum disorder

Frontiers in cellular neuroscience, 2023-11, Vol.17, p.1270489-1270489

2023

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Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors

Proceedings of the National Academy of Sciences - PNAS, 2010-08, Vol.107 (33), p.14845-14850

2010

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Highly efficient generation of isogenic pluripotent stem cell models using prime editing

eLife, 2022-09, Vol.11

2022

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Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility

Nature communications, 2019-11, Vol.10 (1), p.5426-19, Article 5426

2019

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Modeling Somatic Mutations Associated With Neurodevelopmental Disorders in Human Brain Organoids

Frontiers in molecular neuroscience, 2022-01, Vol.14, p.787243-787243

2022

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Corticostriatal Transmission Is Selectively Enhanced in Striatonigral Neurons with Postnatal Loss of Tsc1

Cell reports (Cambridge), 2018-06, Vol.23 (11), p.3197-3208

2018

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Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum

The Journal of neuroscience, 2008-10, Vol.28 (42), p.10460-10471

2008

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Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs

Nature neuroscience, 2008-08, Vol.11 (8), p.932-939

2008

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Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2

eLife, 2022-07, Vol.11

2022

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Loss of Tsc1 from striatal direct pathway neurons impairs endocannabinoid-LTD and enhances motor routine learning

Cell reports (Cambridge), 2021-08, Vol.36 (6), p.109511-109511, Article 109511

2021

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Dopamine- and cAMP-regulated Phosphoprotein of 32-kDa (DARPP-32)-dependent Activation of Extracellular Signal-regulated Kinase (ERK) and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Experimental Parkinsonism

The Journal of biological chemistry, 2012-08, Vol.287 (33), p.27806-27812

2012

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Generation of a DAT-P2A-Flpo mouse line for intersectional genetic targeting of dopamine neuron subpopulations

Cell reports (Cambridge), 2021-05, Vol.35 (6), p.109123-109123, Article 109123

2021

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Loss of Tsc1 from striatal direct pathway neurons impairs endocannabinoid-LTD and enhances motor routine learning

Cell reports (Cambridge), 2022-03, Vol.38 (12), p.110563-110563, Article 110563

2022

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Current Approaches and Future Directions for the Treatment of mTORopathies

Developmental neuroscience, 2021-01, Vol.43 (3-4), p.143-158

2021

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Nucleus Accumbens Subnuclei Regulate Motivated Behavior via Direct Inhibition and Disinhibition of VTA Dopamine Subpopulations

Neuron (Cambridge, Mass.), 2018-01, Vol.97 (2), p.434-449.e4

2018

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Role of adrenoceptors in the regulation of dopamine/DARPP-32 signaling in neostriatal neurons

Journal of neurochemistry, 2010-05, Vol.113 (4), p.1046-1059

2010

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Establishment of Genome-edited Human Pluripotent Stem Cell Lines: From Targeting to Isolation

Journal of visualized experiments, 2016-02 (108), p.e53583-e53583

2016

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Transient food insecurity during the juvenile-adolescent period affects adult weight, cognitive flexibility, and dopamine neurobiology

Current biology, 2022-09, Vol.32 (17), p.3690-3703.e5

2022

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Genetically engineered human cortical spheroid models of tuberous sclerosis

Excitatory/Inhibitory Synaptic Imbalance Leads to Hippocampal Hyperexcitability in Mouse Models of Tuberous Sclerosis

Dopaminergic Dysregulation in Syndromic Autism Spectrum Disorders: Insights From Genetic Mouse Models

Raptor downregulation rescues neuronal phenotypes in mouse models of Tuberous Sclerosis Complex

Global Transcriptional and Translational Repression in Human-Embryonic-Stem-Cell-Derived Rett Syndrome Neurons

Interferon-independent STING signaling promotes resistance to HSV-1 in vivo

Widespread Translational Remodeling during Human Neuronal Differentiation

Altered motor learning and coordination in mouse models of autism spectrum disorder

Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors

Highly efficient generation of isogenic pluripotent stem cell models using prime editing

Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility

Modeling Somatic Mutations Associated With Neurodevelopmental Disorders in Human Brain Organoids

Corticostriatal Transmission Is Selectively Enhanced in Striatonigral Neurons with Postnatal Loss of Tsc1

Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum

Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2

Loss of Tsc1 from striatal direct pathway neurons impairs endocannabinoid-LTD and enhances motor routine learning

Dopamine- and cAMP-regulated Phosphoprotein of 32-kDa (DARPP-32)-dependent Activation of Extracellular Signal-regulated Kinase (ERK) and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Experimental Parkinsonism

Generation of a DAT-P2A-Flpo mouse line for intersectional genetic targeting of dopamine neuron subpopulations

Loss of Tsc1 from striatal direct pathway neurons impairs endocannabinoid-LTD and enhances motor routine learning

Current Approaches and Future Directions for the Treatment of mTORopathies

Nucleus Accumbens Subnuclei Regulate Motivated Behavior via Direct Inhibition and Disinhibition of VTA Dopamine Subpopulations

Role of adrenoceptors in the regulation of dopamine/DARPP-32 signaling in neostriatal neurons

Establishment of Genome-edited Human Pluripotent Stem Cell Lines: From Targeting to Isolation

Transient food insecurity during the juvenile-adolescent period affects adult weight, cognitive flexibility, and dopamine neurobiology

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