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Polyfluorinated groups in medicinal chemistry

Future medicinal chemistry, 2015-03, Vol.7 (4), p.527-546

2015

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SARS-CoV-2 Virus−Host Interaction: Currently Available Structures and Implications of Variant Emergence on Infectivity and Immune Response

International journal of molecular sciences, 2021-10, Vol.22 (19), p.10836

2021

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Targeting the Complement Serine Protease MASP-2 as a Therapeutic Strategy for Coronavirus Infections

Viruses, 2021-02, Vol.13 (2), p.312

2021

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Structural investigations on the mitochondrial uncouplers niclosamide and FCCP

FEBS open bio, 2024-07, Vol.14 (7), p.1057-1071

2024

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Targeting the Viral Polymerase of Diarrhea-Causing Viruses as a Strategy to Develop a Single Broad-Spectrum Antiviral Therapy

Viruses, 2019-02, Vol.11 (2), p.173

2019

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Conjugating uncoupler compounds with hydrophobic hydrocarbon chains to achieve adipose tissue selective drug accumulation

Scientific reports, 2024-02, Vol.14 (1), p.4932-4932, Article 4932

2024

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CHIKV strains Brazil (wt) and Ross (lab-adapted) differ with regard to cell host range and antiviral sensitivity and show CPE in human glioblastoma cell lines U138 and U251

Virus genes, 2022-06, Vol.58 (3), p.188-202

2022

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Stereo-Specific Modulation of the Extracellular Calcium-Sensing Receptor in Colon Cancer Cells

International journal of molecular sciences, 2021-09, Vol.22 (18), p.10124

2021

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Computational Studies towards the Identification of Novel Rhodopsin-Binding Compounds as Chemical Chaperones for Misfolded Opsins

Molecules (Basel, Switzerland), 2020-10, Vol.25 (21), p.4904

2020

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Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C

PLoS biology, 2020-11, Vol.18 (11), p.e3000904

2020

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In silico screening for human norovirus antivirals reveals a novel non-nucleoside inhibitor of the viral polymerase

Scientific reports, 2018-03, Vol.8 (1), p.4129-18, Article 4129

2018

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Novel Nucleoside Analogues as Effective Antiviral Agents for Zika Virus Infections

Molecules (Basel, Switzerland), 2020-10, Vol.25 (20), p.4813

2020

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Concise Synthesis and Biological Evaluation of 2‑Aroyl-5-Amino Benzo[b]thiophene Derivatives As a Novel Class of Potent Antimitotic Agents

Journal of medicinal chemistry, 2013-11, Vol.56 (22), p.9296-9309

2013

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The calcium-sensing receptor modulates the prostaglandin E2 pathway in intestinal inflammation

Frontiers in pharmacology, 2023-04, Vol.14, p.1151144-1151144

2023

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Structural Investigations on Novel Non-Nucleoside Inhibitors of Human Norovirus Polymerase

Viruses, 2022-12, Vol.15 (1), p.74

2022

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Design, synthesis and biological evaluation of 3,5-disubstituted 2-amino thiophene derivatives as a novel class of antitumor agents

Bioorganic & medicinal chemistry, 2014-09, Vol.22 (18), p.5097-5109

2014

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In silico structure-based design and synthesis of novel anti-RSV compounds

Antiviral research, 2015-10, Vol.122, p.46-50

2015

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Structure–Activity Relationship Studies on Novel Antiviral Agents for Norovirus Infections

Microorganisms (Basel), 2021-08, Vol.9 (9), p.1795

2021

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Novel symmetrical phenylenediamines as potential anti-hepatitis C virus agents

Antiviral chemistry & chemotherapy, 2015-12, Vol.24 (5-6), p.155-160

2015

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Therapeutic use of fluorinated nucleosides - progress in patents

Pharmaceutical patent analyst, 2018-11, Vol.7 (6), p.277-299

2018

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Rational design of novel nucleoside analogues reveals potent antiviral agents for EV71

European journal of medicinal chemistry, 2023-01, Vol.246, p.114942-114942, Article 114942

2023

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Ligand-based rational design, synthesis and evaluation of novel potential chemical chaperones for opsin

European journal of medicinal chemistry, 2021-12, Vol.226, p.113841-113841, Article 113841

2021

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Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer

European journal of medicinal chemistry, 2016-08, Vol.118, p.230-243

2016

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A new series of bicalutamide, enzalutamide and enobosarm derivatives carrying pentafluorosulfanyl (SF5) and pentafluoroethyl (C2F5) substituents: Improved antiproliferative agents against prostate cancer

European journal of medicinal chemistry, 2019-10, Vol.180, p.1-14

2019

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Exploring the Fatty Acid Binding Pocket in the SARS-CoV‑2 Spike Protein – Confirmed and Potential Ligands

Journal of chemical information and modeling, 2023-12, Vol.63 (23), p.7282-7298

2023

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Polyfluorinated groups in medicinal chemistry

SARS-CoV-2 Virus−Host Interaction: Currently Available Structures and Implications of Variant Emergence on Infectivity and Immune Response

Targeting the Complement Serine Protease MASP-2 as a Therapeutic Strategy for Coronavirus Infections

Structural investigations on the mitochondrial uncouplers niclosamide and FCCP

Targeting the Viral Polymerase of Diarrhea-Causing Viruses as a Strategy to Develop a Single Broad-Spectrum Antiviral Therapy

Conjugating uncoupler compounds with hydrophobic hydrocarbon chains to achieve adipose tissue selective drug accumulation

CHIKV strains Brazil (wt) and Ross (lab-adapted) differ with regard to cell host range and antiviral sensitivity and show CPE in human glioblastoma cell lines U138 and U251

Stereo-Specific Modulation of the Extracellular Calcium-Sensing Receptor in Colon Cancer Cells

Computational Studies towards the Identification of Novel Rhodopsin-Binding Compounds as Chemical Chaperones for Misfolded Opsins

Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C

In silico screening for human norovirus antivirals reveals a novel non-nucleoside inhibitor of the viral polymerase

Novel Nucleoside Analogues as Effective Antiviral Agents for Zika Virus Infections

Concise Synthesis and Biological Evaluation of 2‑Aroyl-5-Amino Benzo[b]thiophene Derivatives As a Novel Class of Potent Antimitotic Agents

The calcium-sensing receptor modulates the prostaglandin E2 pathway in intestinal inflammation

Structural Investigations on Novel Non-Nucleoside Inhibitors of Human Norovirus Polymerase

Design, synthesis and biological evaluation of 3,5-disubstituted 2-amino thiophene derivatives as a novel class of antitumor agents

In silico structure-based design and synthesis of novel anti-RSV compounds

Structure–Activity Relationship Studies on Novel Antiviral Agents for Norovirus Infections

Novel symmetrical phenylenediamines as potential anti-hepatitis C virus agents

Therapeutic use of fluorinated nucleosides - progress in patents

Rational design of novel nucleoside analogues reveals potent antiviral agents for EV71

Ligand-based rational design, synthesis and evaluation of novel potential chemical chaperones for opsin

Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer

A new series of bicalutamide, enzalutamide and enobosarm derivatives carrying pentafluorosulfanyl (SF5) and pentafluoroethyl (C2F5) substituents: Improved antiproliferative agents against prostate cancer

Exploring the Fatty Acid Binding Pocket in the SARS-CoV‑2 Spike Protein – Confirmed and Potential Ligands

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