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Dose-ranging evaluation of intravitreal siRNA PF-04523655 for diabetic macular edema (the DEGAS study)

Investigative ophthalmology & visual science, 2012-11, Vol.53 (12), p.7666-7674

2012

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Gene Expression Profiling of Transporters in the Solute Carrier and ATP-Binding Cassette Superfamilies in Human Eye Substructures

Molecular pharmaceutics, 2013-02, Vol.10 (2), p.650-663

2013

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Characterization of Central Inhibitory Muscarinic Autoreceptors by the Use of Muscarinic Acetylcholine Receptor Knock-Out Mice

The Journal of neuroscience, 2002-03, Vol.22 (5), p.1709-1717

2002

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Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function

Journal of neurochemistry, 2001-02, Vol.76 (3), p.846-854

2001

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Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide

Journal of neuroinflammation, 2004-04, Vol.1 (1), p.2-2

2004

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Deletion of the M5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia

Proceedings of the National Academy of Sciences - PNAS, 2002-08, Vol.99 (17), p.11452-11457

2002

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Amitifadine, a triple monoamine uptake inhibitor, reduces binge drinking and negative affect in an animal model of co-occurring alcoholism and depression symptomatology

Pharmacology, biochemistry and behavior, 2012-11, Vol.103 (1), p.111-118

2012

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Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain

The Journal of pharmacology and experimental therapeutics, 2007-06, Vol.321 (3), p.1208-1225

2007

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Evaluation of Muscarinic Agonist-Induced Analgesia in Muscarinic Acetylcholine Receptor Knockout Mice

Molecular pharmacology, 2002-11, Vol.62 (5), p.1084-1093

2002

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Induction of serine racemase expression and D-serine release from microglia by secreted amyloid precursor protein (sAPP)

Current Alzheimer research, 2007-07, Vol.4 (3), p.243-251

2007

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Preclinical evaluation of the abuse potential of the analgesic bicifadine

The Journal of pharmacology and experimental therapeutics, 2009-07, Vol.330 (1), p.236-248

2009

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Mice Transgenically Overexpressing Sulfonylurea Receptor 1 in Forebrain Resist Seizure Induction and Excitotoxic Neuron Death

Proceedings of the National Academy of Sciences - PNAS, 2001-03, Vol.98 (6), p.3549-3554

2001

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Peripheral benzodiazepine receptors and mitochondrial function

Neurochemistry international, 2002-05, Vol.40 (6), p.475-486

2002

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M2 Muscarinic Acetylcholine Receptor Knock-Out Mice Show Deficits in Behavioral Flexibility, Working Memory, and Hippocampal Plasticity

The Journal of neuroscience, 2004-11, Vol.24 (45), p.10117-10127

2004

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Multiple Muscarinic Acetylcholine Receptor Subtypes Modulate Striatal Dopamine Release, as Studied with M1-M5 Muscarinic Receptor Knock-Out Mice

The Journal of neuroscience, 2002-08, Vol.22 (15), p.6347-6352

2002

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The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity

The Journal of pharmacology and experimental therapeutics, 2008-03, Vol.324 (3), p.1111-1126

2008

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Pharmacological profile of the "triple" monoamine neurotransmitter uptake inhibitor, DOV 102,677

Cellular and molecular neurobiology, 2006-07, Vol.26 (4-6), p.857-871

2006

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A pulmonary formulation of L-dopa enhances its effectiveness in a rat model of Parkinson's disease

The Journal of pharmacology and experimental therapeutics, 2004-08, Vol.310 (2), p.828-835

2004

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RTP801 gene expression is differentially upregulated in retinopathy and is silenced by PF-04523655, a 19-Mer siRNA directed against RTP801

Investigative ophthalmology & visual science, 2014-03, Vol.55 (3), p.1232-1240

2014

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Inhibitors of cyclooxygenase-2, but not cyclooxygenase-1 provide structural and functional protection against quinolinic acid-induced neurodegeneration

The Journal of pharmacology and experimental therapeutics, 2003-07, Vol.306 (1), p.218-228

2003

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Population Pharmacokinetics of Pegaptanib in Patients With Neovascular, Age-Related Macular Degeneration

Journal of clinical pharmacology, 2012-08, Vol.52 (8), p.1186-1199

2012

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Molecular Basis of Peripheral vs Central Benzodiazepine Receptor Selectivity in a New Class of Peripheral Benzodiazepine Receptor Ligands Related to Alpidem

Journal of medicinal chemistry, 1996-10, Vol.39 (21), p.4275-4284

1996

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Triple reuptake inhibitors ("broad spectrum" antidepressants)

CNS & neurological disorders drug targets, 2007-04, Vol.6 (2), p.141-149

2007

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Population pharmacokinetics of pegaptanib sodium (Macugen(®)) in patients with diabetic macular edema

Clinical ophthalmology (Auckland, N.Z.), 2015-01, Vol.9 (default), p.323-335

2015

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Dose-ranging evaluation of intravitreal siRNA PF-04523655 for diabetic macular edema (the DEGAS study)

Gene Expression Profiling of Transporters in the Solute Carrier and ATP-Binding Cassette Superfamilies in Human Eye Substructures

Characterization of Central Inhibitory Muscarinic Autoreceptors by the Use of Muscarinic Acetylcholine Receptor Knock-Out Mice

Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function

Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide

Deletion of the M5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia

Amitifadine, a triple monoamine uptake inhibitor, reduces binge drinking and negative affect in an animal model of co-occurring alcoholism and depression symptomatology

Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain

Evaluation of Muscarinic Agonist-Induced Analgesia in Muscarinic Acetylcholine Receptor Knockout Mice

Induction of serine racemase expression and D-serine release from microglia by secreted amyloid precursor protein (sAPP)

Preclinical evaluation of the abuse potential of the analgesic bicifadine

Mice Transgenically Overexpressing Sulfonylurea Receptor 1 in Forebrain Resist Seizure Induction and Excitotoxic Neuron Death

Peripheral benzodiazepine receptors and mitochondrial function

The PET tracer [ 11 C]MK-6884 quantifies M4 muscarinic receptor in rhesus monkeys and patients with Alzheimer’s disease

M2 Muscarinic Acetylcholine Receptor Knock-Out Mice Show Deficits in Behavioral Flexibility, Working Memory, and Hippocampal Plasticity

Multiple Muscarinic Acetylcholine Receptor Subtypes Modulate Striatal Dopamine Release, as Studied with M1-M5 Muscarinic Receptor Knock-Out Mice

The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity

Pharmacological profile of the "triple" monoamine neurotransmitter uptake inhibitor, DOV 102,677

A pulmonary formulation of L-dopa enhances its effectiveness in a rat model of Parkinson's disease

RTP801 gene expression is differentially upregulated in retinopathy and is silenced by PF-04523655, a 19-Mer siRNA directed against RTP801

Inhibitors of cyclooxygenase-2, but not cyclooxygenase-1 provide structural and functional protection against quinolinic acid-induced neurodegeneration

Population Pharmacokinetics of Pegaptanib in Patients With Neovascular, Age-Related Macular Degeneration

Molecular Basis of Peripheral vs Central Benzodiazepine Receptor Selectivity in a New Class of Peripheral Benzodiazepine Receptor Ligands Related to Alpidem

Triple reuptake inhibitors ("broad spectrum" antidepressants)

Population pharmacokinetics of pegaptanib sodium (Macugen(®)) in patients with diabetic macular edema

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