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Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

Blood, 2013-08, Vol.122 (6), p.1017-1025

2013

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Impact of enzyme concentration and residence time on apparent activity recovery in jump dilution analysis

Analytical biochemistry, 2011-09, Vol.416 (2), p.206-210

2011

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Computer-aided design of non-nucleoside inhibitors of HIV-1 reverse transcriptase

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (3), p.663-667

2006

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Defining a Molecular Mechanism of Synergy between Nucleoside and Nonnucleoside AIDS Drugs

The Journal of biological chemistry, 2004-02, Vol.279 (8), p.6221-6224

2004

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Envelope Variable Region 4 Is the First Target of Neutralizing Antibodies in Early Simian Immunodeficiency Virus mac251 Infection of Rhesus Monkeys

Journal of Virology, 2012-07, Vol.86 (13), p.7052-7059

2012

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Developing novel nonnucleoside HIV-1 reverse transcriptase inhibitors: beyond the butterfly

Current pharmaceutical design, 2006-05, Vol.12 (15), p.1857

2006

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Mechanistic Studies to Understand the Progressive Development of Resistance in Human Immunodeficiency Virus Type 1 Reverse Transcriptase to Abacavir

The Journal of biological chemistry, 2002-10, Vol.277 (43), p.40479-40490

2002

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Probing the Molecular Mechanisms of AZT Drug Resistance Mediated by HIV-1 Reverse Transcriptase Using a Transient Kinetic Analysis

Biochemistry (Easton), 2003-07, Vol.42 (29), p.8831-8841

2003

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Corrigendum to “Impact of enzyme concentration and residence time on apparent activity recovery in jump dilution analysis” [Anal. Biochem. 416 (2011) 206–210]

Analytical biochemistry, 2022-05, Vol.645, p.114637-114637, Article 114637

2022

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Envelope Vaccination Shapes Viral Envelope Evolution following Simian Immunodeficiency Virus Infection in Rhesus Monkeys

Journal of Virology, 2010-01, Vol.84 (2), p.953-963

2010

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Conformational Adaptation Drives Potent, Selective and Durable Inhibition of the Human Protein Methyltransferase DOT1L

Chemical biology & drug design, 2012-12, Vol.80 (6), p.971-980

2012

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Reverse transcription of the HIV‐1 pandemic

The FASEB journal, 2007-12, Vol.21 (14), p.3795-3808

2007

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Abstract 104: ATF7IP does not alter the substrate specificity of the lysine methyltransferase SETDB1

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.104-104

2015

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Exploring drug delivery for the DOT1L inhibitor pinometostat (EPZ-5676): Subcutaneous administration as an alternative to continuous IV infusion, in the pursuit of an epigenetic target

Journal of controlled release, 2015-12, Vol.220 (Pt B), p.758-765

2015

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Characterization of the Enzymatic Activity of SETDB1 and Its 1:1 Complex with ATF7IP

Biochemistry (Easton), 2016-03, Vol.55 (11), p.1645-1651

2016

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Abstract PR10: IK-595, a MEK-RAF complex inhibitor, obviates CRAF mediated resistance resulting in superior RAS/MAPK pathway inhibition and anti-tumor activity in RAS/RAF altered cancers

Molecular cancer research, 2023-05, Vol.21 (5_Supplement), p.PR10-PR10

2023

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Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor

Biopharmaceutics & drug disposition, 2014-05, Vol.35 (4), p.237-252

2014

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Probing the Mechanistic Consequences of 5-Fluorine Substitution on Cytidine Nucleotide Analogue Incorporation by HIV-1 Reverse Transcriptase

Antiviral Chemistry and Chemotherapy, 2003-06, Vol.14 (3), p.115-125

2003

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Mechanism of Action of (-)-(2R,4R)-1-(2-hydroxymethyl-1,3-dioxolan-4-yl)thymine as an anti-HIV agent

Antiviral chemistry & chemotherapy, 2007-04, Vol.18 (2), p.83-92

2007

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Preclinical Characterization of a Potent, Selective Inhibitor of the Protein Methyltransferase DOT1L for Use in the Treatment of MLL-Rearranged Leukemia

Blood, 2012-11, Vol.120 (21), p.2379-2379

2012

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Bifunctional inhibition of HIV-1 reverse transcriptase: A first step in designing a bifunctional triphosphate

Bioorganic & medicinal chemistry letters, 2013-03, Vol.23 (5), p.1511-1518

2013

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C-2-Aryl O-substituted HI-236 derivatives as non-nucleoside HIV-1 reverse-transcriptase inhibitors

Bioorganic & medicinal chemistry, 2008-12, Vol.16 (24), p.10270-10280

2008

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Optimization of diarylamines as non-nucleoside inhibitors of HIV-1 reverse transcriptase

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (3), p.668-671

2006

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[d4U]-butyne-[HI-236] as a non-cleavable, bifunctional NRTI/NNRTI HIV-1 reverse-transcriptase inhibitor

Bioorganic & medicinal chemistry letters, 2007-05, Vol.17 (9), p.2614-2617

2007

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Modulation of Human Immunodeficiency Virus Type 1 Synergistic Inhibition by Reverse Transcriptase Mutations

Biochemistry (Easton), 2006-06, Vol.45 (23), p.7334-7340

2006

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Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

Impact of enzyme concentration and residence time on apparent activity recovery in jump dilution analysis

Computer-aided design of non-nucleoside inhibitors of HIV-1 reverse transcriptase

Defining a Molecular Mechanism of Synergy between Nucleoside and Nonnucleoside AIDS Drugs

Envelope Variable Region 4 Is the First Target of Neutralizing Antibodies in Early Simian Immunodeficiency Virus mac251 Infection of Rhesus Monkeys

Developing novel nonnucleoside HIV-1 reverse transcriptase inhibitors: beyond the butterfly

Mechanistic Studies to Understand the Progressive Development of Resistance in Human Immunodeficiency Virus Type 1 Reverse Transcriptase to Abacavir

Probing the Molecular Mechanisms of AZT Drug Resistance Mediated by HIV-1 Reverse Transcriptase Using a Transient Kinetic Analysis

Corrigendum to “Impact of enzyme concentration and residence time on apparent activity recovery in jump dilution analysis” [Anal. Biochem. 416 (2011) 206–210]

Envelope Vaccination Shapes Viral Envelope Evolution following Simian Immunodeficiency Virus Infection in Rhesus Monkeys

Conformational Adaptation Drives Potent, Selective and Durable Inhibition of the Human Protein Methyltransferase DOT1L

Reverse transcription of the HIV‐1 pandemic

Abstract 104: ATF7IP does not alter the substrate specificity of the lysine methyltransferase SETDB1

Exploring drug delivery for the DOT1L inhibitor pinometostat (EPZ-5676): Subcutaneous administration as an alternative to continuous IV infusion, in the pursuit of an epigenetic target

Characterization of the Enzymatic Activity of SETDB1 and Its 1:1 Complex with ATF7IP

Abstract PR10: IK-595, a MEK-RAF complex inhibitor, obviates CRAF mediated resistance resulting in superior RAS/MAPK pathway inhibition and anti-tumor activity in RAS/RAF altered cancers

Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor

Probing the Mechanistic Consequences of 5-Fluorine Substitution on Cytidine Nucleotide Analogue Incorporation by HIV-1 Reverse Transcriptase

Mechanism of Action of (-)-(2R,4R)-1-(2-hydroxymethyl-1,3-dioxolan-4-yl)thymine as an anti-HIV agent

Preclinical Characterization of a Potent, Selective Inhibitor of the Protein Methyltransferase DOT1L for Use in the Treatment of MLL-Rearranged Leukemia

Bifunctional inhibition of HIV-1 reverse transcriptase: A first step in designing a bifunctional triphosphate

C-2-Aryl O-substituted HI-236 derivatives as non-nucleoside HIV-1 reverse-transcriptase inhibitors

Optimization of diarylamines as non-nucleoside inhibitors of HIV-1 reverse transcriptase

[d4U]-butyne-[HI-236] as a non-cleavable, bifunctional NRTI/NNRTI HIV-1 reverse-transcriptase inhibitor

Modulation of Human Immunodeficiency Virus Type 1 Synergistic Inhibition by Reverse Transcriptase Mutations

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