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Inhibition of immune checkpoints PD-1, CTLA-4, and IDO1 coordinately induces immune-mediated liver injury in mice

PloS one, 2019-05, Vol.14 (5), p.e0217276

2019

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Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging

Proceedings of the National Academy of Sciences - PNAS, 2007-09, Vol.104 (39), p.15549-15554

2007

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Physicochemical and Biological Characterization of Targeted, Nucleic Acid-Containing Nanoparticles

Bioconjugate chemistry, 2007-03, Vol.18 (2), p.456-468

2007

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Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles

Biotechnology and bioengineering, 2008-03, Vol.99 (4), p.975-985

2008

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Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma

Cancer research (Chicago, Ill.), 2005-10, Vol.65 (19), p.8984-8992

2005

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Effect of siRNA nuclease stability on the in vitro and in vivo kinetics of siRNA-mediated gene silencing

Biotechnology and bioengineering, 2007-07, Vol.97 (4), p.909-921

2007

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A Microfluidic Perfusion Platform for In Vitro Analysis of Drug Pharmacokinetic-Pharmacodynamic (PK-PD) Relationships

The AAPS journal, 2020-03, Vol.22 (2), p.53, Article 53

2020

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Preclinical Efficacy of the Camptothecin-Polymer Conjugate IT-101 in Multiple Cancer Models

Clinical cancer research, 2006-03, Vol.12 (5), p.1606-1614

2006

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Translational PK-PD for targeted protein degradation

Chemical Society reviews, 2022-05, Vol.51 (9), p.3477-3486

2022

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Potent siRNA Inhibitors of Ribonucleotide Reductase Subunit RRM2 Reduce Cell Proliferation In vitro and In vivo

Clinical cancer research, 2007-04, Vol.13 (7), p.2207-2215

2007

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A kinetic proofreading model for bispecific protein degraders

Journal of pharmacokinetics and pharmacodynamics, 2021-02, Vol.48 (1), p.149-163

2021

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Delivering on the promise of protein degraders

Nature reviews. Drug discovery, 2023-05, Vol.22 (5), p.410-427

2023

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Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging

Nucleic acids research, 2006-01, Vol.34 (1), p.322-333

2006

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Increasing dialysate flow and dialyzer mass transfer area coefficient to increase the clearance of protein-bound solutes

Journal of the American Society of Nephrology, 2004-07, Vol.15 (7), p.1927-1935

2004

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Development of an In Vivo Retrodialysis Calibration Method Using Stable Isotope Labeling to Monitor Metabolic Pathways in the Tumor Microenvironment via Microdialysis

Journal of pharmaceutical sciences, 2019-09, Vol.108 (9), p.3124-3129

2019

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A Quantitative Systems Pharmacology Platform to Investigate the Impact of Alirocumab and Cholesterol-Lowering Therapies on Lipid Profiles and Plaque Characteristics

Gene Regulation and Systems Biology, 2017-06, Vol.2017 (11), p.1177625017710941-1177625017710941

2017

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Noninvasive Imaging of PSMA in prostate tumors with (89)Zr-Labeled huJ591 engineered antibody fragments: the faster alternatives

Molecular pharmaceutics, 2014-11, Vol.11 (11), p.3965

2014

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Activatable fluorescent cys-diabody conjugated with indocyanine green derivative: consideration of fluorescent catabolite kinetics on molecular imaging

Journal of biomedical optics, 2013-10, Vol.18 (10), p.101304-101304

2013

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Noninvasive Imaging of PSMA in Prostate Tumors with 89Zr-Labeled huJ591 Engineered Antibody Fragments: The Faster Alternatives

Molecular pharmaceutics, 2014-11, Vol.11 (11), p.3965-3973

2014

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Rapid and Efficient Production of Radiolabeled Antibody Conjugates Using Vacuum Diafiltration Guided by Mathematical Modeling

Bioconjugate chemistry, 2008-09, Vol.19 (9), p.1927-1937

2008

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705. A Practical Approach to siRNA-Based Treatment Design Using Bioluminescent Imaging and Mathematical Modeling

Molecular therapy, 2006-05, Vol.13 (S1), p.S272-S273

2006

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Noninvasive Imaging of PSMA in Prostate Tumors with 89 Zr-Labeled huJ591 Engineered Antibody Fragments: The Faster Alternatives

Molecular pharmaceutics, 2014-11, Vol.11 (11), p.3965-3973

2014

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De novo protein design: how do we expand into the universe of possible protein structures?

Current opinion in structural biology, 2015-08, Vol.33, p.16-26

2015

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CCBuilder: an interactive web-based tool for building, designing and assessing coiled-coil protein assemblies

Bioinformatics (Oxford, England), 2014-11, Vol.30 (21), p.3029-3035

2014

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Computational design of water-soluble α-helical barrels

Science (American Association for the Advancement of Science), 2014-10, Vol.346 (6208), p.485-488

2014

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Inhibition of immune checkpoints PD-1, CTLA-4, and IDO1 coordinately induces immune-mediated liver injury in mice

Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging

Physicochemical and Biological Characterization of Targeted, Nucleic Acid-Containing Nanoparticles

Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles

Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma

Effect of siRNA nuclease stability on the in vitro and in vivo kinetics of siRNA-mediated gene silencing

A Microfluidic Perfusion Platform for In Vitro Analysis of Drug Pharmacokinetic-Pharmacodynamic (PK-PD) Relationships

Preclinical Efficacy of the Camptothecin-Polymer Conjugate IT-101 in Multiple Cancer Models

Translational PK-PD for targeted protein degradation

Potent siRNA Inhibitors of Ribonucleotide Reductase Subunit RRM2 Reduce Cell Proliferation In vitro and In vivo

A kinetic proofreading model for bispecific protein degraders

Delivering on the promise of protein degraders

Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging

Increasing dialysate flow and dialyzer mass transfer area coefficient to increase the clearance of protein-bound solutes

Development of an In Vivo Retrodialysis Calibration Method Using Stable Isotope Labeling to Monitor Metabolic Pathways in the Tumor Microenvironment via Microdialysis

A Quantitative Systems Pharmacology Platform to Investigate the Impact of Alirocumab and Cholesterol-Lowering Therapies on Lipid Profiles and Plaque Characteristics

Noninvasive Imaging of PSMA in prostate tumors with (89)Zr-Labeled huJ591 engineered antibody fragments: the faster alternatives

Activatable fluorescent cys-diabody conjugated with indocyanine green derivative: consideration of fluorescent catabolite kinetics on molecular imaging

Noninvasive Imaging of PSMA in Prostate Tumors with 89Zr-Labeled huJ591 Engineered Antibody Fragments: The Faster Alternatives

Rapid and Efficient Production of Radiolabeled Antibody Conjugates Using Vacuum Diafiltration Guided by Mathematical Modeling

705. A Practical Approach to siRNA-Based Treatment Design Using Bioluminescent Imaging and Mathematical Modeling

Noninvasive Imaging of PSMA in Prostate Tumors with 89 Zr-Labeled huJ591 Engineered Antibody Fragments: The Faster Alternatives

De novo protein design: how do we expand into the universe of possible protein structures?

CCBuilder: an interactive web-based tool for building, designing and assessing coiled-coil protein assemblies

Computational design of water-soluble α-helical barrels

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