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Inositol Pyrophosphates Mediate the DNA-PK/ATM-p53 Cell Death Pathway by Regulating CK2 Phosphorylation of Tti1/Tel2

Molecular cell, 2014-04, Vol.54 (1), p.119-132

2014

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The Role of Inositol Hexakisphosphate Kinase in the Central Nervous System

Biomolecules (Basel, Switzerland), 2023-08, Vol.13 (9), p.1317

2023

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Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1

Proceedings of the National Academy of Sciences - PNAS, 2015-02, Vol.112 (6), p.1773-1778

2015

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Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function

Proceedings of the National Academy of Sciences - PNAS, 2016-03, Vol.113 (13), p.3503-3508

2016

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DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response

Oncotarget, 2014-06, Vol.5 (12), p.4361-4369

2014

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Inhibitors of Catechol-O-Methyltransferase

CNS & neurological disorders drug targets, 2012-05, Vol.11 (3), p.324

Barrow, James C

2012

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The IP6K Inhibitor LI-2242 Ameliorates Diet-Induced Obesity, Hyperglycemia, and Hepatic Steatosis in Mice by Improving Cell Metabolism and Insulin Signaling

Biomolecules (Basel, Switzerland), 2023-05, Vol.13 (5), p.868

2023

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Inhibition of Catechol- O -methyltransferase Does Not Alter Effort-Related Choice Behavior in a Fixed Ratio/Concurrent Chow Task in Male Mice

Frontiers in behavioral neuroscience, 2020-05, Vol.14, p.73-73

2020

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TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway

Molecular metabolism (Germany), 2016-10, Vol.5 (10), p.903-917

2016

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Classics in Chemical Neuroscience: Diazepam (Valium)

ACS chemical neuroscience, 2014-04, Vol.5 (4), p.253-260

2014

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The Importance of PK–PD

Journal of medicinal chemistry, 2023-04, Vol.66 (7), p.4273-4274

2023

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A Method for Touchscreen‐Based Oral Self‐Administration of Oxycodone in Mice

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT)

ACS medicinal chemistry letters, 2015-03, Vol.6 (3), p.318-323

2015

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Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis

The Journal of clinical investigation, 2016-11, Vol.126 (11), p.4273-4288

2016

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A Medicinal Chemist’s Perspective on Transitioning from Industry to Academic Drug Discovery

ACS medicinal chemistry letters, 2019-05, Vol.10 (5), p.687-689

Barrow, James C

2019

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Synthesis and characterization of novel isoform-selective IP6K1 inhibitors

Bioorganic & medicinal chemistry letters, 2019-10, Vol.29 (19), p.126628-126628, Article 126628

2019

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Post-weaning social isolation increases ΔFosB/FosB protein expression in sex-specific patterns in the prelimbic/infralimbic cortex and hippocampus in mice

Neuroscience letters, 2021-01, Vol.740, p.135423, Article 135423

2021

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Total Syntheses of Vancomycin and Eremomycin Aglycons

Angewandte Chemie (International ed.), 1998-10, Vol.37 (19), p.2700-2704

1998

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Asymmetric Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C

Journal of the American Chemical Society, 1994-12, Vol.116 (26), p.12111-12112

1994

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Degrading stimuli by reducing image resolution impairs performance in a rodent continuous performance test

Behavioural processes, 2023-10, Vol.212, p.104941-104941, Article 104941

2023

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Novel, non-nitrocatechol catechol-O-methyltransferase inhibitors modulate dopamine neurotransmission in the frontal cortex and improve cognitive flexibility

Psychopharmacology, 2020-09, Vol.237 (9), p.2695-2707

2020

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Development of a PC12 Cell Based Assay for Screening Catechol‑O‑methyltransferase Inhibitors

ACS chemical neuroscience, 2019-10, Vol.10 (10), p.4221-4226

2019

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Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis

Journal of medicinal chemistry, 2015-10, Vol.58 (19), p.7888-7894

2015

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Fragment-Based Screening Identifies New Quinazolinone-Based Inositol Hexakisphosphate Kinase (IP6K) Inhibitors

ACS medicinal chemistry letters, 2023-12, Vol.14 (12), p.1760-1766

2023

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Inositol Pyrophosphates Mediate the DNA-PK/ATM-p53 Cell Death Pathway by Regulating CK2 Phosphorylation of Tti1/Tel2

Molecular cell, 2020-08, Vol.79 (4), p.702-702

2020

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Inositol Pyrophosphates Mediate the DNA-PK/ATM-p53 Cell Death Pathway by Regulating CK2 Phosphorylation of Tti1/Tel2

The Role of Inositol Hexakisphosphate Kinase in the Central Nervous System

Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1

Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function

DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response

Inhibitors of Catechol-O-Methyltransferase

The IP6K Inhibitor LI-2242 Ameliorates Diet-Induced Obesity, Hyperglycemia, and Hepatic Steatosis in Mice by Improving Cell Metabolism and Insulin Signaling

Inhibition of Catechol- O -methyltransferase Does Not Alter Effort-Related Choice Behavior in a Fixed Ratio/Concurrent Chow Task in Male Mice

TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway

Classics in Chemical Neuroscience: Diazepam (Valium)

The Importance of PK–PD

A Method for Touchscreen‐Based Oral Self‐Administration of Oxycodone in Mice

Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT)

Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis

A Medicinal Chemist’s Perspective on Transitioning from Industry to Academic Drug Discovery

Synthesis and characterization of novel isoform-selective IP6K1 inhibitors

Post-weaning social isolation increases ΔFosB/FosB protein expression in sex-specific patterns in the prelimbic/infralimbic cortex and hippocampus in mice

Total Syntheses of Vancomycin and Eremomycin Aglycons

Asymmetric Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C

Degrading stimuli by reducing image resolution impairs performance in a rodent continuous performance test

Novel, non-nitrocatechol catechol-O-methyltransferase inhibitors modulate dopamine neurotransmission in the frontal cortex and improve cognitive flexibility

Development of a PC12 Cell Based Assay for Screening Catechol‑O‑methyltransferase Inhibitors

Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis

Fragment-Based Screening Identifies New Quinazolinone-Based Inositol Hexakisphosphate Kinase (IP6K) Inhibitors

Inositol Pyrophosphates Mediate the DNA-PK/ATM-p53 Cell Death Pathway by Regulating CK2 Phosphorylation of Tti1/Tel2

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