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Fluorogenic probes for imaging cellular phosphatase activity

Current opinion in chemical biology, 2020-08, Vol.57, p.34-40

2020

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Early Endosomal Escape of a Cyclic Cell-Penetrating Peptide Allows Effective Cytosolic Cargo Delivery

Biochemistry (Easton), 2014-06, Vol.53 (24), p.4034-4046

2014

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A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

Nature medicine, 2012-06, Vol.18 (6), p.956-960

2012

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PTPs: Degrading the Undruggable

Journal of medicinal chemistry, 2020-07, Vol.63 (14), p.7508-7509

Barrios, Amy M

2020

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Gold(I)-Mediated Inhibition of Protein Tyrosine Phosphatases: A Detailed in Vitro and Cellular Study

Journal of medicinal chemistry, 2008-08, Vol.51 (15), p.4790-4795

2008

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Identification of Cystathionine β-Synthase Inhibitors Using a Hydrogen Sulfide Selective Probe

Angewandte Chemie International Edition, 2013-04, Vol.52 (17), p.4641-4644

2013

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Identification of Cystathionine [beta]-Synthase Inhibitors Using a Hydrogen Sulfide Selective Probe

Angewandte Chemie International Edition, 2013-04, Vol.52 (17), p.4641-4644

International ed. in English, 2013

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Histidine phosphorylation in metalloprotein binding sites

Journal of inorganic biochemistry, 2021-12, Vol.225, p.111606-111606, Article 111606

2021

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High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45

Proceedings of the National Academy of Sciences - PNAS, 2012-08, Vol.109 (35), p.13972-13977

2012

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Identifying Selective Protein Tyrosine Phosphatase Substrates and Inhibitors from a Fluorogenic, Combinatorial Peptide Library

Chembiochem : a European journal of chemical biology, 2008-05, Vol.9 (8), p.1216-1219

2008

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Efficient Delivery of Cyclic Peptides into Mammalian Cells with Short Sequence Motifs

ACS chemical biology, 2013-02, Vol.8 (2), p.423-431

2013

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Facile, Fluorogenic Assay for Protein Histidine Phosphatase Activity

Biochemistry (Easton), 2018-05, Vol.57 (18), p.2584-2589

2018

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Front Cover: Derivatives of the Fungal Natural Product Illudalic Acid Inhibit the Activity of Protein Histidine Phosphatase PHPT1 (ChemMedChem 15/2023)

ChemMedChem, 2023-08, Vol.18 (15), p.n/a

2023

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Inhibitor Screen Identifies Covalent Inhibitors of the Protein Histidine Phosphatase PHPT1

ACS medicinal chemistry letters, 2022-07, Vol.13 (7), p.1198-1201

2022

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Synthesis and PTP Inhibitory Activity of Illudalic Acid and Its Methyl Ether, with Insights into Selectivity for LAR PTP over Other Tyrosine Phosphatases under Physiologically Relevant Conditions

Journal of natural products (Washington, D.C.), 2019-12, Vol.82 (12), p.3386-3393

2019

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A luminogenic lanthanide-based probe for the highly selective detection of nanomolar sulfide levels in aqueous samples

Chemical communications (Cambridge, England), 2017-05, Vol.53 (36), p.4911-4914

2017

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In Vitro Assays for Measuring Protein Histidine Phosphatase Activity

Methods in molecular biology (Clifton, N.J.), 2020, Vol.2077, p.109

2020

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Derivatives of the Fungal Natural Product Illudalic Acid Inhibit the Activity of Protein Histidine Phosphatase PHPT1

ChemMedChem, 2023-08, Vol.18 (15), p.e202300187-n/a

2023

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Rational design of a SHP-2 targeted, fluorogenic peptide substrate

Bioorganic & medicinal chemistry letters, 2019-09, Vol.29 (17), p.2452-2454

2019

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Synthesis of illudalic acid and analogous phosphatase inhibitors

Organic & biomolecular chemistry, 2021-12, Vol.19 (48), p.1596-16

2021

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The mechanism of covalent inhibition of LAR phosphatase by illudalic acid

Bioorganic & medicinal chemistry letters, 2024-05, Vol.104, p.129740-129740, Article 129740

2024

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Inhibition of cathepsin B by Au(I) complexes: a kinetic and computational study

Journal of biological inorganic chemistry, 2008-05, Vol.13 (4), p.555-561

2008

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Cellular biochemistry methods for investigating protein tyrosine phosphatases

Antioxidants & redox signaling, 2014-05, Vol.20 (14), p.2160-2178

2014

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Decomposition of Alkyl-Substituted Urea Molecules at a Hydroxide-Bridged Dinickel Center

Inorganic chemistry, 2001-03, Vol.40 (6), p.1250-1255

2001

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A Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune Diseases

Journal of medicinal chemistry, 2013-06, Vol.56 (12), p.4990-5008

2013

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Fluorogenic probes for imaging cellular phosphatase activity

Early Endosomal Escape of a Cyclic Cell-Penetrating Peptide Allows Effective Cytosolic Cargo Delivery

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

PTPs: Degrading the Undruggable

Gold(I)-Mediated Inhibition of Protein Tyrosine Phosphatases: A Detailed in Vitro and Cellular Study

Identification of Cystathionine β-Synthase Inhibitors Using a Hydrogen Sulfide Selective Probe

Identification of Cystathionine [beta]-Synthase Inhibitors Using a Hydrogen Sulfide Selective Probe

Histidine phosphorylation in metalloprotein binding sites

High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45

Identifying Selective Protein Tyrosine Phosphatase Substrates and Inhibitors from a Fluorogenic, Combinatorial Peptide Library

Efficient Delivery of Cyclic Peptides into Mammalian Cells with Short Sequence Motifs

Facile, Fluorogenic Assay for Protein Histidine Phosphatase Activity

Front Cover: Derivatives of the Fungal Natural Product Illudalic Acid Inhibit the Activity of Protein Histidine Phosphatase PHPT1 (ChemMedChem 15/2023)

Inhibitor Screen Identifies Covalent Inhibitors of the Protein Histidine Phosphatase PHPT1

Synthesis and PTP Inhibitory Activity of Illudalic Acid and Its Methyl Ether, with Insights into Selectivity for LAR PTP over Other Tyrosine Phosphatases under Physiologically Relevant Conditions

A luminogenic lanthanide-based probe for the highly selective detection of nanomolar sulfide levels in aqueous samples

In Vitro Assays for Measuring Protein Histidine Phosphatase Activity

Derivatives of the Fungal Natural Product Illudalic Acid Inhibit the Activity of Protein Histidine Phosphatase PHPT1

Rational design of a SHP-2 targeted, fluorogenic peptide substrate

Synthesis of illudalic acid and analogous phosphatase inhibitors

The mechanism of covalent inhibition of LAR phosphatase by illudalic acid

Inhibition of cathepsin B by Au(I) complexes: a kinetic and computational study

Cellular biochemistry methods for investigating protein tyrosine phosphatases

Decomposition of Alkyl-Substituted Urea Molecules at a Hydroxide-Bridged Dinickel Center

A Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune Diseases

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