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Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling

PloS one, 2012-01, Vol.7 (1), p.e28568

2012

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Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor

Molecular oncology, 2018-03, Vol.12 (3), p.287-304

2018

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In vitro and In vivo Pharmacokinetic-Pharmacodynamic Relationships for the Trisubstituted Aminopurine Cyclin-Dependent Kinase Inhibitors Olomoucine, Bohemine and CYC202

Clinical cancer research, 2005-07, Vol.11 (13), p.4875-4888

2005

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Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2

PloS one, 2013-06, Vol.8 (6), p.e65689-e65689

2013

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Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange

The EMBO journal, 2006-07, Vol.25 (13), p.3179-3190

2006

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High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells

Analytical biochemistry, 2003-09, Vol.320 (1), p.66-74

2003

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The 16,17-Double Bond Is Needed for Irreversible Inhibition of Human Cytochrome P45017 α by Abiraterone (17-(3-Pyridyl)androsta-5,16-dien-3β-ol) and Related Steroidal Inhibitors

Journal of medicinal chemistry, 1998-12, Vol.41 (27), p.5375-5381

1998

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Establishment and Characterization of Acquired Resistance to the Farnesyl Protein Transferase Inhibitor R115777 in a Human Colon Cancer Cell Line

Clinical cancer research, 2002-06, Vol.8 (6), p.2002-2009

2002

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CYP17 inhibition as a hormonal strategy for prostate cancer

Nature clinical practice urology, 2008-11, Vol.5 (11), p.610-620

2008

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Molecular profiling and combinatorial activity of CCT 068127: a potent CDK 2 and CDK 9 inhibitor

Molecular oncology, 2018-03, Vol.12 (3), p.287-304

2018

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Abstract 3692: High-throughput cell-based screen for inhibitors of AR activity

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.3692-3692

2010

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Novel steroidal inhibitors of human cytochrome P45017α (17α-hydroxylase-C17,20-lyase) : potential agents for the treatment of prostatic cancer

Journal of medicinal chemistry, 1995-06, Vol.38 (13), p.2463-2471

1995

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Novel Steroidal Inhibitors of Human Cytochrome P45017.alpha.-Hydroxylase-C17,20-lyase): Potential Agents for the Treatment of Prostatic Cancer

Journal of medicinal chemistry, 1995-06, Vol.38 (13), p.2463-2471

1995

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Dinucleotide analogs as inhibitors of thymidine kinase, thymidylate kinase and ribonucleotide reductase

Journal of medicinal chemistry, 1988-07, Vol.31 (7), p.1305-1308

1988

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Esters of 3-pyridylacetic acid that combine potent inhibition of 17α-hydroxylase/C17,20-lyase (cytochrome P45017α) with resistance to esterase hydrolysis

Journal of medicinal chemistry, 1995-10, Vol.38 (21), p.4191-4197

1995

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A reappraisal of the effect upon thymidine kinase of thymidine derivatives carrying large groups at the 5'-position

Journal of medicinal chemistry, 1984-08, Vol.27 (8), p.1044-1047

1984

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3- and 4-pyridylalkyl adamantanecarboxylates: inhibitors of human cytochrome P450(17 alpha) (17 alpha-hydroxylase/C17,20-lyase). Potential nonsteroidal agents for the treatment of prostatic cancer

Journal of medicinal chemistry, 1996-08, Vol.39 (17), p.3319-3323

1996

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The 16,17-Double Bond Is Needed for Irreversible Inhibition of Human Cytochrome P450 17 α by Abiraterone (17-(3-Pyridyl)androsta-5,16-dien-3β-ol) and Related Steroidal Inhibitors

Journal of medicinal chemistry, 1998-12, Vol.41 (27), p.5375-5381

1998

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Inhibition of enzymes of estrogen and androgen biosynthesis by esters of 4-pyridylacetic acid

Journal of medicinal chemistry, 1990-11, Vol.33 (11), p.3050-3055

1990

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3- and 4-Pyridylalkyl Adamantanecarboxylates: Inhibitors of Human Cytochrome P450 17 α (17 α-Hydroxylase/C 17,20 -Lyase). Potential Nonsteroidal Agents for the Treatment of Prostatic Cancer

Journal of medicinal chemistry, 1996-01, Vol.39 (17), p.3319-3323

1996

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Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis

Journal of medicinal chemistry, 1990-09, Vol.33 (9), p.2452-2455

1990

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Esters of 3-Pyridylacetic Acid That Combine Potent Inhibition of 17.alpha.-Hydroxylase/C17,20-Lyase (Cytochrome P45017.alpha.) with Resistance to Esterase Hydrolysis

Journal of medicinal chemistry, 1995-10, Vol.38 (21), p.4191-4197

1995

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3- and 4-Pyridylalkyl Adamantanecarboxylates: Inhibitors of Human Cytochrome P45017 α (17α-Hydroxylase/C17,20-Lyase). Potential Nonsteroidal Agents for the Treatment of Prostatic Cancer

Journal of medicinal chemistry, 1996-08, Vol.39 (17), p.3319-3323

1996

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Evaluation of Some 4-Fluoro-and 4-Cyano Derivatives of δ4, 3-Ketosteroids as Inhibitors of Testosterone 5α-Reductase

Journal of enzyme inhibition, 1994, Vol.8 (1), p.17-23

1994

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Talking about Leaving Revisited: Persistence, Relocation, and Loss in Undergraduate STEM Education

1st ed. 2019., 2019

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Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling

Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor

In vitro and In vivo Pharmacokinetic-Pharmacodynamic Relationships for the Trisubstituted Aminopurine Cyclin-Dependent Kinase Inhibitors Olomoucine, Bohemine and CYC202

Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2

Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange

High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells

The 16,17-Double Bond Is Needed for Irreversible Inhibition of Human Cytochrome P45017 α by Abiraterone (17-(3-Pyridyl)androsta-5,16-dien-3β-ol) and Related Steroidal Inhibitors

Establishment and Characterization of Acquired Resistance to the Farnesyl Protein Transferase Inhibitor R115777 in a Human Colon Cancer Cell Line

CYP17 inhibition as a hormonal strategy for prostate cancer

Molecular profiling and combinatorial activity of CCT 068127: a potent CDK 2 and CDK 9 inhibitor

Abstract 3692: High-throughput cell-based screen for inhibitors of AR activity

Novel steroidal inhibitors of human cytochrome P45017α (17α-hydroxylase-C17,20-lyase) : potential agents for the treatment of prostatic cancer

Novel Steroidal Inhibitors of Human Cytochrome P45017.alpha.-Hydroxylase-C17,20-lyase): Potential Agents for the Treatment of Prostatic Cancer

Dinucleotide analogs as inhibitors of thymidine kinase, thymidylate kinase and ribonucleotide reductase

Esters of 3-pyridylacetic acid that combine potent inhibition of 17α-hydroxylase/C17,20-lyase (cytochrome P45017α) with resistance to esterase hydrolysis

A reappraisal of the effect upon thymidine kinase of thymidine derivatives carrying large groups at the 5'-position

3- and 4-pyridylalkyl adamantanecarboxylates: inhibitors of human cytochrome P450(17 alpha) (17 alpha-hydroxylase/C17,20-lyase). Potential nonsteroidal agents for the treatment of prostatic cancer

The 16,17-Double Bond Is Needed for Irreversible Inhibition of Human Cytochrome P450 17 α by Abiraterone (17-(3-Pyridyl)androsta-5,16-dien-3β-ol) and Related Steroidal Inhibitors

Inhibition of enzymes of estrogen and androgen biosynthesis by esters of 4-pyridylacetic acid

3- and 4-Pyridylalkyl Adamantanecarboxylates: Inhibitors of Human Cytochrome P450 17 α (17 α-Hydroxylase/C 17,20 -Lyase). Potential Nonsteroidal Agents for the Treatment of Prostatic Cancer

Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis

Esters of 3-Pyridylacetic Acid That Combine Potent Inhibition of 17.alpha.-Hydroxylase/C17,20-Lyase (Cytochrome P45017.alpha.) with Resistance to Esterase Hydrolysis

3- and 4-Pyridylalkyl Adamantanecarboxylates: Inhibitors of Human Cytochrome P45017 α (17α-Hydroxylase/C17,20-Lyase). Potential Nonsteroidal Agents for the Treatment of Prostatic Cancer

Evaluation of Some 4-Fluoro-and 4-Cyano Derivatives of δ4, 3-Ketosteroids as Inhibitors of Testosterone 5α-Reductase

Talking about Leaving Revisited: Persistence, Relocation, and Loss in Undergraduate STEM Education

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