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KCNQ-Encoded Potassium Channels as Therapeutic Targets

Annual review of pharmacology and toxicology, 2018-01, Vol.58 (1), p.625-648

2018

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Epileptic channelopathies caused by neuronal Kv7 (KCNQ) channel dysfunction

Pflügers Archiv, 2020-07, Vol.472 (7), p.881-898

2020

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Genotype–phenotype correlations in neonatal epilepsies caused by mutations in the voltage sensor of Kᵥ7.2 potassium channel subunits

Proceedings of the National Academy of Sciences - PNAS, 2013-03, Vol.110 (11), p.4386-4391

2013

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Kv7 Channel Activation Underpins EPAC-Dependent Relaxations of Rat Arteries

Arteriosclerosis, thrombosis, and vascular biology, 2016-12, Vol.36 (12), p.2404-2411

2016

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Editorial: Kv7 Channels: Structure, Physiology, and Pharmacology

Frontiers in physiology, 2021-04, Vol.12, p.679317-679317

2021

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SMIT (Sodium-Myo-Inositol Transporter) 1 Regulates Arterial Contractility Through the Modulation of Vascular Kv7 Channels

Arteriosclerosis, thrombosis, and vascular biology, 2020-10, Vol.40 (10), p.2468-2480

2020

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G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity

Proceedings of the National Academy of Sciences - PNAS, 2015-05, Vol.112 (20), p.6497-6502

2015

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Contribution of Kv7 channels to natriuretic peptide mediated vasodilation in normal and hypertensive rats

Hypertension (Dallas, Tex. 1979), 2015-03, Vol.65 (3), p.676-682

2015

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New advances in beta-blocker therapy in heart failure

Frontiers in physiology, 2013-01, Vol.4, p.323-323

2013

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Specification of skeletal muscle differentiation by repressor element-1 silencing transcription factor (REST)-regulated Kv7.4 potassium channels

Molecular biology of the cell, 2013-02, Vol.24 (3), p.274-284

2013

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Expression, localization, and pharmacological role of Kv7 potassium channels in skeletal muscle proliferation, differentiation, and survival after myotoxic insults

The Journal of pharmacology and experimental therapeutics, 2010-03, Vol.332 (3), p.811

2010

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Kv7.2 and Kv7.3 potassium channel subunits as new central regulators of blood pressure

Cardiovascular research, 2022-01, Vol.118 (2), p.345-346

2022

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Key role for Kv11.1 (ether‐a‐go‐go related gene) channels in rat bladder contractility

Physiological reports, 2023-02, Vol.11 (3), p.e15583-n/a

2023

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A Novel Kv7.3 Variant in the Voltage-Sensing S4 Segment in a Family With Benign Neonatal Epilepsy: Functional Characterization and in vitro Rescue by β-Hydroxybutyrate

Frontiers in physiology, 2020-09, Vol.11, p.1040

2020

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In Vitro Neurochemical Assessment of Methylphenidate and Its "Legal High" Analogs 3,4-CTMP and Ethylphenidate in Rat Nucleus Accumbens and Bed Nucleus of the Stria Terminalis

Frontiers in psychiatry, 2018-05, Vol.9, p.149-149

2018

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Proliferative Role of Kv11 Channels in Murine Arteries

Frontiers in physiology, 2017-07, Vol.8, p.500-500

2017

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Decreased Subunit Stability as a Novel Mechanism for Potassium Current Impairment by a KCNQ2 C Terminus Mutation Causing Benign Familial Neonatal Convulsions

The Journal of biological chemistry, 2006-01, Vol.281 (1), p.418-428

2006

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Involvement of KCNQ2 subunits in [³H]dopamine release triggered by depolarization and pre-synaptic muscarinic receptor activation from rat striatal synaptosomes

Journal of neurochemistry, 2007-07, Vol.102 (1), p.179-193

2007

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Genotype-phenotype correlations in neonatal epilepsies caused by mutations in the voltage sensor of K(v)7.2 potassium channel subunits

Proceedings of the National Academy of Sciences - PNAS, 2013-03, Vol.110 (11), p.4386

2013

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Gain-of-function effects by pore variants in Kv7.2 and Kv7.3 potassium channel subunits causing developmental and epileptic encephalopathy

Biophysical journal, 2024-02, Vol.123 (3), p.527a-528a

2024

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Kv7 channel activation reduces brain endothelial cell permeability and prevents kainic acid-induced blood-brain barrier damage

American Journal of Physiology: Cell Physiology, 2024-03, Vol.326 (3), p.C893-C904

2024

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Investigating the Role of G Protein βγ in Kv7-Dependent Relaxations of the Rat Vasculature

Arteriosclerosis, thrombosis, and vascular biology, 2018-09, Vol.38 (9), p.2091-2102

2018

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Gain of function due to increased opening probability by two KCNQ5 pore variants causing developmental and epileptic encephalopathy

Proceedings of the National Academy of Sciences - PNAS, 2022-04, Vol.119 (15), p.e2116887119-e2116887119

2022

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Kv7.4 channels regulate potassium permeability in neuronal mitochondria

Biochemical pharmacology, 2022-03, Vol.197, p.114931-114931, Article 114931

2022

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Beyond Retigabine: Design, Synthesis, and Pharmacological Characterization of a Potent and Chemically Stable Neuronal Kv7 Channel Activator with Anticonvulsant Activity

Journal of medicinal chemistry, 2022-08, Vol.65 (16), p.11340-11364

2022

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KCNQ-Encoded Potassium Channels as Therapeutic Targets

Epileptic channelopathies caused by neuronal Kv7 (KCNQ) channel dysfunction

Genotype–phenotype correlations in neonatal epilepsies caused by mutations in the voltage sensor of Kᵥ7.2 potassium channel subunits

Kv7 Channel Activation Underpins EPAC-Dependent Relaxations of Rat Arteries

Editorial: Kv7 Channels: Structure, Physiology, and Pharmacology

SMIT (Sodium-Myo-Inositol Transporter) 1 Regulates Arterial Contractility Through the Modulation of Vascular Kv7 Channels

G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity

Contribution of Kv7 channels to natriuretic peptide mediated vasodilation in normal and hypertensive rats

New advances in beta-blocker therapy in heart failure

Specification of skeletal muscle differentiation by repressor element-1 silencing transcription factor (REST)-regulated Kv7.4 potassium channels

Expression, localization, and pharmacological role of Kv7 potassium channels in skeletal muscle proliferation, differentiation, and survival after myotoxic insults

Kv7.2 and Kv7.3 potassium channel subunits as new central regulators of blood pressure

Key role for Kv11.1 (ether‐a‐go‐go related gene) channels in rat bladder contractility

A Novel Kv7.3 Variant in the Voltage-Sensing S4 Segment in a Family With Benign Neonatal Epilepsy: Functional Characterization and in vitro Rescue by β-Hydroxybutyrate

In Vitro Neurochemical Assessment of Methylphenidate and Its "Legal High" Analogs 3,4-CTMP and Ethylphenidate in Rat Nucleus Accumbens and Bed Nucleus of the Stria Terminalis

Proliferative Role of Kv11 Channels in Murine Arteries

Decreased Subunit Stability as a Novel Mechanism for Potassium Current Impairment by a KCNQ2 C Terminus Mutation Causing Benign Familial Neonatal Convulsions

Involvement of KCNQ2 subunits in [³H]dopamine release triggered by depolarization and pre-synaptic muscarinic receptor activation from rat striatal synaptosomes

Genotype-phenotype correlations in neonatal epilepsies caused by mutations in the voltage sensor of K(v)7.2 potassium channel subunits

Gain-of-function effects by pore variants in Kv7.2 and Kv7.3 potassium channel subunits causing developmental and epileptic encephalopathy

Kv7 channel activation reduces brain endothelial cell permeability and prevents kainic acid-induced blood-brain barrier damage

Investigating the Role of G Protein βγ in Kv7-Dependent Relaxations of the Rat Vasculature

Gain of function due to increased opening probability by two KCNQ5 pore variants causing developmental and epileptic encephalopathy

Kv7.4 channels regulate potassium permeability in neuronal mitochondria

Beyond Retigabine: Design, Synthesis, and Pharmacological Characterization of a Potent and Chemically Stable Neuronal Kv7 Channel Activator with Anticonvulsant Activity

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