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Metformin induces apoptosis through AMPK-dependent inhibition of UPR signaling in ALL lymphoblasts

PloS one, 2013-08, Vol.8 (8), p.e74420

2013

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Acute lymphoblastic leukemia mortality in Hispanic Americans

Leukemia & lymphoma, 2020-09, Vol.61 (11), p.2674-2681

2020

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Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKβ leading to autophagy

Biochemical pharmacology, 2013-05, Vol.85 (10), p.1463-1477

2013

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Protein Kinase D-Dependent Downregulation of Immediate Early Genes through Class IIA Histone Deacetylases in Acute Lymphoblastic Leukemia

Molecular cancer research, 2021-08, Vol.19 (8), p.1296-1307

2021

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AMPK and Akt determine apoptotic cell death following perturbations of one-carbon metabolism by regulating ER stress in acute lymphoblastic leukemia

Molecular cancer therapeutics, 2011-03, Vol.10 (3), p.437-447

2011

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The Effect of Health Insurance on Pediatric Cancer Survival: An Analysis of Children Evaluated for Radiation Therapy in Diverse Multicenter Health Systems

Journal of pediatric hematology/oncology, 2023-08, Vol.45 (6), p.e662

2023

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Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy

Molecular cancer, 2007-07, Vol.6 (1), p.46-46, Article 46

2007

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Late isolated central nervous system relapse in childhood B‐cell acute lymphoblastic leukemia treated with intensified systemic therapy and delayed reduced dose cranial radiation: A report from the Children's Oncology Group study AALL02P2

Pediatric blood & cancer, 2021-12, Vol.68 (12), p.e29256-n/a

2021

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Inhibition of Akt potentiates 2-DG-induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia

Molecular cancer research, 2012-07, Vol.10 (7), p.969-978

2012

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AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia

Journal of molecular signaling, 2010-09, Vol.5 (1), p.15-15

2010

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A phase I window, dose escalating and safety trial of metformin in combination with induction chemotherapy in relapsed refractory acute lymphoblastic leukemia: Metformin with induction chemotherapy of vincristine, dexamethasone, PEG‐asparaginase, and doxorubicin

Pediatric blood & cancer, 2018-09, Vol.65 (9), p.e27224-n/a

2018

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Isolated late testicular relapse of B‐cell acute lymphoblastic leukemia treated with intensive systemic chemotherapy and response‐based testicular radiation: A Children's Oncology Group study

Pediatric blood & cancer, 2018-05, Vol.65 (5), p.e26928-n/a

2018

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The NEDD8-activating enzyme inhibitor pevonedistat activates the eIF2α and mTOR pathways inducing UPR-mediated cell death in acute lymphoblastic leukemia

Leukemia research, 2016-11, Vol.50, p.1-10

2016

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Isolated CNS Relapse of Acute Lymphoblastic Leukemia Treated With Intensive Systemic Chemotherapy and Delayed CNS Radiation: A Pediatric Oncology Group Study

Journal of clinical oncology, 2006-07, Vol.24 (19), p.3142-3149

2006

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Inhibition of the NEDD8 conjugation pathway induces calcium-dependent compensatory activation of the pro-survival MEK/ERK pathway in acute lymphoblastic leukemia

Oncotarget, 2018-01, Vol.9 (5), p.5529-5544

2018

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Effect of a formal oncofertility program on fertility preservation rates-first year experience

Translational andrology and urology, 2018-07, Vol.7 (Suppl 3), p.S271-S275

2018

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Primary Mediastinal Large B-Cell Lymphoma With Translocations Involving BCL6 and MYC (Double-Hit Lymphoma)

American journal of clinical pathology, 2016-05, Vol.145 (5), p.710-716

2016

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Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress

Leukemia research, 2015-11, Vol.39 (11), p.1246-1254

2015

Volltextzugriff (PDF)

Adenoid cystic carcinoma of the lacrimal gland in a 14-year-old male

Orbit (Amsterdam), 2017-12, Vol.36 (6), p.448-451

2017

Volltextzugriff (PDF)

Folylpolyglutamate Synthetase Gene Transcription is Regulated by a Multiprotein Complex that Binds the TEL-AML1 Fusion in Acute Lymphoblastic Leukemia

Leukemia research, 2010-12, Vol.34 (12), p.1601-1609

2010

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The pediatric hydroxyurea phase III clinical trial (BABY HUG): Challenges of study design

Pediatric blood & cancer, 2010-02, Vol.54 (2), p.250-255

2010

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AMPK Reprograms Gene Expression and Promotes Adaptation/Survival in Response to Metabolic Stress through Binding to a Chromatin-Associated Transcription Complex in Acute Lymphoblastic Leukemia

Blood, 2021-11, Vol.138 (Supplement 1), p.3299-3299

2021

Volltextzugriff (PDF)

Analysis of folylpoly-gamma-glutamate synthetase gene expression in human B-precursor ALL and T-lineage ALL cells

BMC cancer, 2006-05, Vol.6 (1), p.132-132, Article 132

2006

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Metformin induces apoptosis through AMPK-dependent inhibition of UPR signaling in ALL lymphoblasts

Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG)

Acute lymphoblastic leukemia mortality in Hispanic Americans

Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKβ leading to autophagy

Protein Kinase D-Dependent Downregulation of Immediate Early Genes through Class IIA Histone Deacetylases in Acute Lymphoblastic Leukemia

AMPK and Akt determine apoptotic cell death following perturbations of one-carbon metabolism by regulating ER stress in acute lymphoblastic leukemia

The Effect of Health Insurance on Pediatric Cancer Survival: An Analysis of Children Evaluated for Radiation Therapy in Diverse Multicenter Health Systems

Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy

Late isolated central nervous system relapse in childhood B‐cell acute lymphoblastic leukemia treated with intensified systemic therapy and delayed reduced dose cranial radiation: A report from the Children's Oncology Group study AALL02P2

Inhibition of Akt potentiates 2-DG-induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia

AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia

A phase I window, dose escalating and safety trial of metformin in combination with induction chemotherapy in relapsed refractory acute lymphoblastic leukemia: Metformin with induction chemotherapy of vincristine, dexamethasone, PEG‐asparaginase, and doxorubicin

Isolated late testicular relapse of B‐cell acute lymphoblastic leukemia treated with intensive systemic chemotherapy and response‐based testicular radiation: A Children's Oncology Group study

The NEDD8-activating enzyme inhibitor pevonedistat activates the eIF2α and mTOR pathways inducing UPR-mediated cell death in acute lymphoblastic leukemia

Isolated CNS Relapse of Acute Lymphoblastic Leukemia Treated With Intensive Systemic Chemotherapy and Delayed CNS Radiation: A Pediatric Oncology Group Study

Inhibition of the NEDD8 conjugation pathway induces calcium-dependent compensatory activation of the pro-survival MEK/ERK pathway in acute lymphoblastic leukemia

Effect of a formal oncofertility program on fertility preservation rates-first year experience

Serum ferritin level changes in children with sickle cell disease on chronic blood transfusion are nonlinear and are associated with iron load and liver injury

Primary Mediastinal Large B-Cell Lymphoma With Translocations Involving BCL6 and MYC (Double-Hit Lymphoma)

Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress

Adenoid cystic carcinoma of the lacrimal gland in a 14-year-old male

Folylpolyglutamate Synthetase Gene Transcription is Regulated by a Multiprotein Complex that Binds the TEL-AML1 Fusion in Acute Lymphoblastic Leukemia

The pediatric hydroxyurea phase III clinical trial (BABY HUG): Challenges of study design

AMPK Reprograms Gene Expression and Promotes Adaptation/Survival in Response to Metabolic Stress through Binding to a Chromatin-Associated Transcription Complex in Acute Lymphoblastic Leukemia

Analysis of folylpoly-gamma-glutamate synthetase gene expression in human B-precursor ALL and T-lineage ALL cells

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