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A sequence level model of an intact locus predicts the location and function of nonadditive enhancers

PloS one, 2017-07, Vol.12 (7), p.e0180861-e0180861

2017

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The relationship between regulatory changes in cis and trans and the evolution of gene expression in humans and chimpanzees

Genome Biology, 2023-09, Vol.24 (1), p.1-21, Article 207

2023

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Correction: A sequence level model of an intact locus predicts the location and function of nonadditive enhancers

PloS one, 2018-05, Vol.13 (5), p.e0197211-e0197211

2018

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Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor

Journal of medicinal chemistry, 2020-02, Vol.63 (4), p.1612-1623

2020

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Energy-aware lossless data compression

ACM transactions on computer systems, 2006-08, Vol.24 (3), p.250-291

2006

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Single-cell sequencing reveals lineage-specific dynamic genetic regulation of gene expression during human cardiomyocyte differentiation

PLoS genetics, 2022-01, Vol.18 (1), p.e1009666

2022

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Characterizing and inferring quantitative cell cycle phase in single-cell RNA-seq data analysis

Genome research, 2020-04, Vol.30 (4), p.611-621

2020

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PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions

The Journal of experimental medicine, 2011-06, Vol.208 (6), p.1179-1188

2011

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Human embryoid bodies as a novel system for genomic studies of functionally diverse cell types

eLife, 2022-02, Vol.11

2022

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Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling

Nature immunology, 2012-03, Vol.13 (3), p.264-271

2012

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An in silico analysis of robust but fragile gene regulation links enhancer length to robustness

PLoS computational biology, 2019-11, Vol.15 (11), p.e1007497

2019

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Aristaless Controls Butterfly Wing Color Variation Used in Mimicry and Mate Choice

Current biology, 2018-11, Vol.28 (21), p.3469-3474.e4

2018

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Allosteric inhibition of protein tyrosine phosphatase 1B

Nature structural & molecular biology, 2004-08, Vol.11 (8), p.730-737

2004

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Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors

Journal of medicinal chemistry, 2019-07, Vol.62 (14), p.6575-6596

2019

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Divergence in alternative polyadenylation contributes to gene regulatory differences between humans and chimpanzees

eLife, 2021-02, Vol.10

2021

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A synthetic biology approach to the development of transcriptional regulatory models and custom enhancer design

Methods (San Diego, Calif.), 2013-07, Vol.62 (1), p.91-98

2013

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Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity

Cell reports (Cambridge), 2016-12, Vol.17 (12), p.3206-3218

2016

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Synthetic enhancer design by in silico compensatory evolution reveals flexibility and constraint in cis-regulation

BMC systems biology, 2017-11, Vol.11 (1), p.116-116, Article 116

2017

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Potent, Orally Active Heterocycle-Based Combretastatin A-4 Analogues: Synthesis, Structure−Activity Relationship, Pharmacokinetics, and In Vivo Antitumor Activity Evaluation

Journal of medicinal chemistry, 2002-04, Vol.45 (8), p.1697-1711

2002

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Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye

ACS medicinal chemistry letters, 2012-03, Vol.3 (3), p.203-206

2012

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Fully interpretable deep learning model of transcriptional control

Bioinformatics (Oxford, England), 2020-07, Vol.36 (Supplement_1), p.i499-i507

2020

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FK506-binding protein (FKBP) partitions a modified HIV protease inhibitor into blood cells and prolongs its lifetime in vivo

Proceedings of the National Academy of Sciences - PNAS, 2009-02, Vol.106 (5), p.1336-1341

2009

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Applications of Vinylogous Mannich Reactions. Concise Enantiospecific Total Syntheses of (+)-Croomine

Journal of the American Chemical Society, 1999-08, Vol.121 (30), p.6990-6997

1999

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Structure–activity relationship (SAR) of the α-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.307-310

2011

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Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors

Bioorganic & medicinal chemistry, 2008-10, Vol.18 (20), p.5648-5652

2008

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A sequence level model of an intact locus predicts the location and function of nonadditive enhancers

The relationship between regulatory changes in cis and trans and the evolution of gene expression in humans and chimpanzees

Correction: A sequence level model of an intact locus predicts the location and function of nonadditive enhancers

Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor

Energy-aware lossless data compression

Single-cell sequencing reveals lineage-specific dynamic genetic regulation of gene expression during human cardiomyocyte differentiation

Characterizing and inferring quantitative cell cycle phase in single-cell RNA-seq data analysis

PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions

Human embryoid bodies as a novel system for genomic studies of functionally diverse cell types

Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling

An in silico analysis of robust but fragile gene regulation links enhancer length to robustness

Aristaless Controls Butterfly Wing Color Variation Used in Mimicry and Mate Choice

Allosteric inhibition of protein tyrosine phosphatase 1B

Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors

Divergence in alternative polyadenylation contributes to gene regulatory differences between humans and chimpanzees

A synthetic biology approach to the development of transcriptional regulatory models and custom enhancer design

Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity

Synthetic enhancer design by in silico compensatory evolution reveals flexibility and constraint in cis-regulation

Potent, Orally Active Heterocycle-Based Combretastatin A-4 Analogues: Synthesis, Structure−Activity Relationship, Pharmacokinetics, and In Vivo Antitumor Activity Evaluation

Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye

Fully interpretable deep learning model of transcriptional control

FK506-binding protein (FKBP) partitions a modified HIV protease inhibitor into blood cells and prolongs its lifetime in vivo

Applications of Vinylogous Mannich Reactions. Concise Enantiospecific Total Syntheses of (+)-Croomine

Structure–activity relationship (SAR) of the α-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists

Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors

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