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CoMFA, Synthesis, and Pharmacological Evaluation of (E)-3-(2-Carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic Acids: 3-[2-(3-Aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic Acid, a Potent Selective Glycine-Site NMDA Receptor Antagonist

Journal of medicinal chemistry, 2005-02, Vol.48 (4), p.995-1018

2005

Volltextzugriff (PDF)

A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms

Neuron (Cambridge, Mass.), 1993-09, Vol.11 (3), p.449-458

1993

Volltextzugriff (PDF)

Binding of 5H-Dibenzo[b,e][1,4]diazepine and Chiral 5H-Dibenzo[a,d]cycloheptene Analogs of Clozapine to Dopamine and Serotonin Receptors

Journal of medicinal chemistry, 1994-08, Vol.37 (17), p.2686-2696

1994

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Two Members of a Distinct Subfamily of 5-Hydroxytryptamine Receptors Differentially Expressed in Rat Brain

Proceedings of the National Academy of Sciences - PNAS, 1993-04, Vol.90 (8), p.3452-3456

1993

Volltextzugriff (PDF)

Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist

European journal of pharmacology, 1997-04, Vol.323 (2), p.181-192

1997

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Binding of the radiolabeled glycine site antagonist [ 3H]MDL 105,519 to homomeric NMDA-NR1a receptors

European journal of pharmacology, 1996-10, Vol.312 (3), p.357-365

1996

Volltextzugriff (PDF)

Chemical Development of MDL 103371: An N-Methyl-d-Aspartate-Type Glycine Receptor Antagonist for the Treatment of Stroke

Organic process research & development, 2000-11, Vol.4 (6), p.477-487

2000

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Development of a prototype reporter-based assay for the evaluation of gap junctional intercellular communication

Biotechnology letters, 2001-10, Vol.23 (19), p.1559-1563

2001

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The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke

Stroke (1970), 1994-06, Vol.25 (6), p.1241-1244

1994

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Characterization of the novel 5-HT3 antagonists MDL 73147EF (dolasetron mesilate) and MDL 74156 in NG108-15 neuroblastoma × glioma cells

European journal of pharmacology, 1992-08, Vol.219 (1), p.9-13

1992

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2,4-Dihydro-3H-1,2,4-triazol-3-ones as anticonvulsant agents

Journal of medicinal chemistry, 1990-10, Vol.33 (10), p.2772-2777

1990

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Enzyme-Activated Antagonists of the Strychnine-Insensitive Glycine/NMDA Receptor

Journal of medicinal chemistry, 1994-02, Vol.37 (3), p.334-336

1994

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Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile

The Journal of pharmacology and experimental therapeutics, 1996-05, Vol.277 (2), p.968

1996

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The selectivity of MDL 74,721 in models of neurogenic versus vascular components of migraine

European journal of pharmacology, 1997-10, Vol.336 (2-3), p.127-136

1997

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Binding of 5H-Dibenzo[a,d]cycloheptene and Dibenz[b,f]oxepin Analogs of Clozapine to Dopamine and Serotonin Receptors

Journal of medicinal chemistry, 1995-02, Vol.38 (4), p.708-714

1995

Volltextzugriff (PDF)

(R)-4-Oxo-5-phosphononorvaline: a new competitive glutamate antagonist at the NMDA receptor complex

Journal of medicinal chemistry, 1990-11, Vol.33 (11), p.2961-2963

1990

Volltextzugriff (PDF)

4-[(Carboxymethyl)oxy]- and 4-[(carboxymethyl)amino]-5,7-dichloroquinoline-2-carboxylic acid: new antagonists of the strychnine-insensitive glycine binding site on the N-methyl-D-aspartate (NMDA) receptor complex

Journal of medicinal chemistry, 1990-12, Vol.33 (12), p.3130-3132

1990

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3-(2-Carboxyindol-3-yl)propionic acid derivatives: antagonists of the strychnine-insensitive glycine receptor associated with the N-methyl-D-aspartate receptor complex

Journal of medicinal chemistry, 1990-11, Vol.33 (11), p.2944-2946

1990

Volltextzugriff (PDF)

3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the NMDA (N-methyl-D-aspartic acid) receptor associated glycine binding site

Journal of medicinal chemistry, 1992-05, Vol.35 (10), p.1791-1799

1992

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Nitric oxide synthesis in the CNS, endothelium and macrophages differs in its sensitivity to inhibition by arginine analogues

Life sciences (1973), 1991, Vol.48 (1), p.69-75

1991

Volltextzugriff (PDF)

[3H]MDL 105,519, a high-affinity radioligand for the N-methyl-D-aspartate receptor-associated glycine recognition site

The Journal of pharmacology and experimental therapeutics, 1996-10, Vol.279 (1), p.62

1996

Volltextzugriff (PDF)

CoMFA, Synthesis, and Pharmacological Evaluation of ( E )-3-(2-Carboxy-2-arylvinyl)-4,6-dichloro-1 H -indole-2-carboxylic Acids: 3-[2-(3-Aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1 H -indole-2-carboxylic Acid, a Potent Selective Glycine-Site NMDA Receptor Antagonist

Journal of medicinal chemistry, 2005-02, Vol.48 (4), p.995-1018

2005

Volltextzugriff (PDF)

Molecular Cloning and Functional Expression of 5-HT1E-Like Rat and Human 5-Hydroxytryptamine Receptor Genes

Proceedings of the National Academy of Sciences - PNAS, 1993-03, Vol.90 (6), p.2184-2188

1993

Volltextzugriff (PDF)

CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-Aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antagonis

Journal of medicinal chemistry, 2005, Vol.48 (4), p.995-1018

2005

Volltextzugriff (PDF)

NMDA receptor complex antagonists have potential anxiolytic effects as measured with separation-induced ultrasonic vocalizations

European journal of pharmacology, 1991-02, Vol.193 (3), p.283-292

1991

Volltextzugriff (PDF)

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CoMFA, Synthesis, and Pharmacological Evaluation of (E)-3-(2-Carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic Acids: 3-[2-(3-Aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic Acid, a Potent Selective Glycine-Site NMDA Receptor Antagonist

A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms

Binding of 5H-Dibenzo[b,e][1,4]diazepine and Chiral 5H-Dibenzo[a,d]cycloheptene Analogs of Clozapine to Dopamine and Serotonin Receptors

Two Members of a Distinct Subfamily of 5-Hydroxytryptamine Receptors Differentially Expressed in Rat Brain

Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist

Binding of the radiolabeled glycine site antagonist [ 3H]MDL 105,519 to homomeric NMDA-NR1a receptors

Chemical Development of MDL 103371: An N-Methyl-d-Aspartate-Type Glycine Receptor Antagonist for the Treatment of Stroke

Development of a prototype reporter-based assay for the evaluation of gap junctional intercellular communication

The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke

Characterization of the novel 5-HT3 antagonists MDL 73147EF (dolasetron mesilate) and MDL 74156 in NG108-15 neuroblastoma × glioma cells

2,4-Dihydro-3H-1,2,4-triazol-3-ones as anticonvulsant agents

Enzyme-Activated Antagonists of the Strychnine-Insensitive Glycine/NMDA Receptor

Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile

The selectivity of MDL 74,721 in models of neurogenic versus vascular components of migraine

Binding of 5H-Dibenzo[a,d]cycloheptene and Dibenz[b,f]oxepin Analogs of Clozapine to Dopamine and Serotonin Receptors

(R)-4-Oxo-5-phosphononorvaline: a new competitive glutamate antagonist at the NMDA receptor complex

4-[(Carboxymethyl)oxy]- and 4-[(carboxymethyl)amino]-5,7-dichloroquinoline-2-carboxylic acid: new antagonists of the strychnine-insensitive glycine binding site on the N-methyl-D-aspartate (NMDA) receptor complex

3-(2-Carboxyindol-3-yl)propionic acid derivatives: antagonists of the strychnine-insensitive glycine receptor associated with the N-methyl-D-aspartate receptor complex

3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the NMDA (N-methyl-D-aspartic acid) receptor associated glycine binding site

Nitric oxide synthesis in the CNS, endothelium and macrophages differs in its sensitivity to inhibition by arginine analogues

[3H]MDL 105,519, a high-affinity radioligand for the N-methyl-D-aspartate receptor-associated glycine recognition site

CoMFA, Synthesis, and Pharmacological Evaluation of ( E )-3-(2-Carboxy-2-arylvinyl)-4,6-dichloro-1 H -indole-2-carboxylic Acids: 3-[2-(3-Aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1 H -indole-2-carboxylic Acid, a Potent Selective Glycine-Site NMDA Receptor Antagonist

Molecular Cloning and Functional Expression of 5-HT1E-Like Rat and Human 5-Hydroxytryptamine Receptor Genes

CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-Aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antagonis

NMDA receptor complex antagonists have potential anxiolytic effects as measured with separation-induced ultrasonic vocalizations

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