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Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

Biochemical journal, 2005-01, Vol.385 (Pt 2), p.399-408

2005

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Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (3), p.761-764

2005

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Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape

Biochemical journal, 2011-04, Vol.435 (2), p.475-487

2011

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Quantitative evaluation of siRNA delivery in vivo

RNA (Cambridge), 2010-12, Vol.16 (12), p.2553-2563

2010

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Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members

Molecular cancer therapeutics, 2005-02, Vol.4 (2), p.271-279

2005

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Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (4), p.905-909

2005

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The PI3K/Akt pathway: recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors

Current cancer drug targets, 2008-02, Vol.8 (1), p.7-18

2008

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The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation

Current topics in medicinal chemistry, 2005-01, Vol.5 (2), p.109-125

2005

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Recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors

Current topics in medicinal chemistry, 2007-07, Vol.7 (14), p.1349-1363

2007

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Allosteric inhibitors of Akt1 and Akt2: A naphthyridinone with efficacy in an A2780 tumor xenograft model

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (11), p.3178-3182

2008

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Allosteric inhibitors of Akt1 and Akt2: Discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.834-836

2009

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Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity

Bioorganic & medicinal chemistry, 2008, Vol.18 (1), p.49-53

2008

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Rapid assembly of diverse and potent allosteric Akt inhibitors

Bioorganic & medicinal chemistry, 2008-03, Vol.18 (6), p.2211-2214

2008

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The design and synthesis of potent and cell-active allosteric dual Akt 1 and 2 inhibitors devoid of hERG activity

Bioorganic & medicinal chemistry, 2008-07, Vol.18 (14), p.4191-4194

2008

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Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors

Bioorganic & medicinal chemistry, 2008-03, Vol.18 (6), p.2194-2197

2008

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Discovery of potent and cell-active allosteric dual Akt 1 and 2 inhibitors

Bioorganic & medicinal chemistry, 2008-07, Vol.18 (14), p.4186-4190

2008

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Development of Pyridopyrimidines as Potent Akt1/2 Inhibitors

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (4), p.1274-1279

2008

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Synthesis and biological evaluation of unnatural canthine alkaloids

Tetrahedron letters, 2005-04, Vol.46 (16), p.2779-2782

2005

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Interactions of the A1 heterogeneous nuclear ribonucleoprotein and its proteolytic derivative, UP1, with RNA and DNA: Evidence for multiple RNA binding domains and salt-dependent binding mode transitions

Biochemistry (Easton), 1991-03, Vol.30 (11), p.2968-2976

1991

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Interfacial Catalysis by Phosphoinositide 3'-Hydroxykinase

Biochemistry (Easton), 1995-10, Vol.34 (43), p.14254-14262

1995

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Primary structure differences between proteins C1 and C2 of HeLa 40S nuclear ribonucleoprotein particles

Nucleic acids research, 1989-11, Vol.17 (21), p.8441-8449

1989

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Allosteric inhibitors of Aktl and Akt2 : Discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (3), p.834-836

2009

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Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Aktl and Akt2 inhibitors

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (6), p.2194-2197

2008

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Allosteric inhibitors of Aktl and Akt2 : A naphthyridinone with efficacy in an A2780 tumor xenograft model

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (11), p.3178-3182

2008

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Transcription Factor E2F Binds DNA as a Heterodimer

Proceedings of the National Academy of Sciences - PNAS, 1993-04, Vol.90 (8), p.3525-3529

1993

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Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape

Quantitative evaluation of siRNA delivery in vivo

Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members

Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors

The PI3K/Akt pathway: recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors

The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation

Recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors

Allosteric inhibitors of Akt1 and Akt2: A naphthyridinone with efficacy in an A2780 tumor xenograft model

Allosteric inhibitors of Akt1 and Akt2: Discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity

Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity

Rapid assembly of diverse and potent allosteric Akt inhibitors

The design and synthesis of potent and cell-active allosteric dual Akt 1 and 2 inhibitors devoid of hERG activity

Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors

Discovery of potent and cell-active allosteric dual Akt 1 and 2 inhibitors

Development of Pyridopyrimidines as Potent Akt1/2 Inhibitors

Synthesis and biological evaluation of unnatural canthine alkaloids

Interactions of the A1 heterogeneous nuclear ribonucleoprotein and its proteolytic derivative, UP1, with RNA and DNA: Evidence for multiple RNA binding domains and salt-dependent binding mode transitions

Interfacial Catalysis by Phosphoinositide 3'-Hydroxykinase

Primary structure differences between proteins C1 and C2 of HeLa 40S nuclear ribonucleoprotein particles

Allosteric inhibitors of Aktl and Akt2 : Discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity

Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Aktl and Akt2 inhibitors

Allosteric inhibitors of Aktl and Akt2 : A naphthyridinone with efficacy in an A2780 tumor xenograft model

Transcription Factor E2F Binds DNA as a Heterodimer

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