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The relationship between the chemistry and biological activity of the bisphosphonates

Bone (New York, N.Y.), 2011-07, Vol.49 (1), p.20-33

2011

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Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy

Annals of the New York Academy of Sciences, 2007-11, Vol.1117 (1), p.209-257

2007

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The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants

Bone (New York, N.Y.), 2015-12, Vol.81, p.478-486

2015

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Structure–Activity Relationships Among the Nitrogen Containing Bisphosphonates in Clinical Use and Other Analogues: Time-Dependent Inhibition of Human Farnesyl Pyrophosphate Synthase

Journal of medicinal chemistry, 2008-04, Vol.51 (7), p.2187-2195

2008

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Case Studies in MicroLED End-to-End Process Control

Proceedings of the International Display Workshops, 2022-12, p.945

2022

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11.3: Invited Paper: MicroLED End‐to‐End Process Control

SID International Symposium Digest of technical papers, 2022-10, Vol.53 (S1), p.125-128

2022

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Farnesyl pyrophosphate synthase enantiospecificity with a chiral risedronate analog, [6,7-dihydro-5 H-cyclopenta[ c]pyridin-7-yl(hydroxy)methylene]bis(phosphonic acid) (NE-10501): Synthetic, structural, and modeling studies

Bioorganic & medicinal chemistry letters, 2008-05, Vol.18 (9), p.2878-2882

2008

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Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors

Proteins, structure, function, and bioinformatics, 2007-02, Vol.66 (3), p.538-546

2007

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Structure activity relationships of nitrogen containing bisphosphonates which induce conformational changes in farnesyl pyrophosphate synthase

Bone (New York, N.Y.), 2008-03, Vol.42, p.S71-S71

2008

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The interaction of sidechain nitrogen with active site threonine is not essential for inhibition of farnesyl pyrophosphate synthase by nitrogen containing bisphosphonates

Bone (New York, N.Y.), 2008-03, Vol.42, p.S70-S71

2008

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A mirror image pair of bisphosphonate analogs further demonstrates the mode of binding of the bisphosphonates in farnesyl pyrophosphate synthase

Bone (New York, N.Y.), 2008-03, Vol.42, p.S36-S37

2008

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Bisphosphonates

Annals of the New York Academy of Sciences, 2007-11, Vol.1117 (1), p.209-257

2007

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Subtilisin BPN‘ Variants: Increased Hydrolytic Activity on Surface-Bound Substrates via Decreased Surface Activity

Biochemistry (Easton), 1996-03, Vol.35 (10), p.3162-3169

1996

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Designed mutants of human farnesyl pyrophosphate synthase (FPPS) help to characterise the interactions of nitrogen-containing bisphosphonates with Tyrosine 204 and Phenylalanine 239 side-chain residues

Bone (New York, N.Y.), 2010, Vol.46, p.S23-S23

2010

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Determination of the relative bone mineral-binding affinities of bisphosphonates by using hydroxyapatite-column chromatography combined with mass spectrometric analysis

Bone (New York, N.Y.), 2010, Vol.46, p.S23-S23

2010

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Molecular interactions of nitrogen-containing bisphosphonates within farnesyl diphosphate synthase

Journal of organometallic chemistry, 2005-05, Vol.690 (10), p.2679-2687

2005

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The Next Generation of MMP Inhibitors: Design and Synthesis

Annals of the New York Academy of Sciences, 1999-06, Vol.878 (1), p.40-60

1999

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Design and synthesis of conformationally-constrained MMP inhibitors

Bioorganic & medicinal chemistry letters, 1998-08, Vol.8 (16), p.2077-2080

1998

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Molecular modeling of the structures of human and rat pancreatic cholesterol esterases

Protein science, 1997-01, Vol.6 (1), p.73-79

1997

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Crystal and molecular structure of tetrakis(2,2,6,6-tetramethyl-3,5-heptanedionato)niobium(IV). Square antiprismatic M(bidentate)4 stereoisomer

Journal of the American Chemical Society, 1975-05, Vol.97 (10), p.2712-2717

1975

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sym-and unsym-Benzoferroles. Ferroles from a cyclobutadieneiron tricarbonyl

Journal of the American Chemical Society, 1974-10, Vol.96 (22), p.7108-7109

1974

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μ3-Trimethylsilylimido-μ3-carbonyl-tris(tricarbonyl-eisen) _ Molekül- und Kristallstruktur

Angewandte Chemie, 1971-12, Vol.83 (23), p.969-970

1971

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Nitrogen-Fixing Trees Benefit Rotation Crops

Journal of forestry, 1986-11, Vol.84 (11), p.48-49

Barnett, Bobby D.

1986

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The molecular configuration of two complexes with σ and π-nickel  carbon bonds. : (π-pentenyl)(diisopropylphenylphosphine)methylnickel(II) and (π-pentenyl)(dimethylmethylphosphine)methyl ncikel(II)

Journal of organometallic chemistry, 1974-09, Vol.77 (3), p.407-421

1974

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Gene 5 Protein - DNA Complex: Modeling Binding Interactions

Journal of biomolecular structure & dynamics, 1990-08, Vol.8 (1), p.1-9

1990

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The relationship between the chemistry and biological activity of the bisphosphonates

Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants

Structure–Activity Relationships Among the Nitrogen Containing Bisphosphonates in Clinical Use and Other Analogues: Time-Dependent Inhibition of Human Farnesyl Pyrophosphate Synthase

Case Studies in MicroLED End-to-End Process Control

11.3: Invited Paper: MicroLED End‐to‐End Process Control

Farnesyl pyrophosphate synthase enantiospecificity with a chiral risedronate analog, [6,7-dihydro-5 H-cyclopenta[ c]pyridin-7-yl(hydroxy)methylene]bis(phosphonic acid) (NE-10501): Synthetic, structural, and modeling studies

Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors

Structure activity relationships of nitrogen containing bisphosphonates which induce conformational changes in farnesyl pyrophosphate synthase

The interaction of sidechain nitrogen with active site threonine is not essential for inhibition of farnesyl pyrophosphate synthase by nitrogen containing bisphosphonates

A mirror image pair of bisphosphonate analogs further demonstrates the mode of binding of the bisphosphonates in farnesyl pyrophosphate synthase

Bisphosphonates

Subtilisin BPN‘ Variants: Increased Hydrolytic Activity on Surface-Bound Substrates via Decreased Surface Activity

Designed mutants of human farnesyl pyrophosphate synthase (FPPS) help to characterise the interactions of nitrogen-containing bisphosphonates with Tyrosine 204 and Phenylalanine 239 side-chain residues

Determination of the relative bone mineral-binding affinities of bisphosphonates by using hydroxyapatite-column chromatography combined with mass spectrometric analysis

Molecular interactions of nitrogen-containing bisphosphonates within farnesyl diphosphate synthase

The Next Generation of MMP Inhibitors: Design and Synthesis

Design and synthesis of conformationally-constrained MMP inhibitors

Molecular modeling of the structures of human and rat pancreatic cholesterol esterases

Crystal and molecular structure of tetrakis(2,2,6,6-tetramethyl-3,5-heptanedionato)niobium(IV). Square antiprismatic M(bidentate)4 stereoisomer

sym-and unsym-Benzoferroles. Ferroles from a cyclobutadieneiron tricarbonyl

μ3-Trimethylsilylimido-μ3-carbonyl-tris(tricarbonyl-eisen) _ Molekül- und Kristallstruktur

Nitrogen-Fixing Trees Benefit Rotation Crops

The molecular configuration of two complexes with σ and π-nickel  carbon bonds. : (π-pentenyl)(diisopropylphenylphosphine)methylnickel(II) and (π-pentenyl)(dimethylmethylphosphine)methyl ncikel(II)

Gene 5 Protein - DNA Complex: Modeling Binding Interactions

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