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LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms

Molecular cancer therapeutics, 2015-09, Vol.14 (9), p.2004-2013

2015

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Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor

Investigational new drugs, 2014-04, Vol.32 (2), p.213-226

2014

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Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy

Molecular cancer therapeutics, 2019-12, Vol.18 (12), p.2207-2219

2019

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LY2603618, a selective CHK1 inhibitor, enhances the anti-tumor effect of gemcitabine in xenograft tumor models

Investigational new drugs, 2016-02, Vol.34 (1), p.49-60

2016

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The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

Nature (London), 1998-11, Vol.396 (6707), p.180-183

1998

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Cyclooxygenase-2 expression in human pancreatic adenocarcinomas

Carcinogenesis (New York), 2000-02, Vol.21 (2), p.139-146

2000

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Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms

Oncogene, 1998-09, Vol.17 (12), p.1539-1547

1998

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Preclinical analyses and phase I evaluation of LY2603618 administered in combination with Pemetrexed and cisplatin in patients with advanced cancer

Investigational new drugs, 2014-10, Vol.32 (5), p.955-968

2014

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Heme Compounds in Dinosaur Trabecular Bone

Proceedings of the National Academy of Sciences - PNAS, 1997-06, Vol.94 (12), p.6291-6296

1997

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Characterization and preclinical development of LY2603618: a selective and potent Chkl inhibitor

Investigational new drugs, 2014, Vol.32 (2), p.213-226

2014

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Abstract A108: LY2606368, a second generation Chk1 inhibitor, inhibits growth of ovarian carcinoma xenografts either as monotherapy or in combination with standard-of-care agents

Molecular cancer therapeutics, 2011-11, Vol.10 (11_Supplement), p.A108-A108

2011

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In VitroInhibition of Ras–Raf Association by Short Peptides

Biochemical and biophysical research communications, 1998-06, Vol.247 (1), p.176-180

1998

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Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling

Molecular and Cellular Biology, 1997-08, Vol.17 (8), p.4509-4516

1997

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Abstract A49: Circulating tumor cell (CTC) assay development for detection of H2AX as a clinical pharmacodynamic (PD) marker for Chk1 kinase inhibitors

Molecular cancer therapeutics, 2011-11, Vol.10 (11_Supplement), p.A49-A49

2011

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Abstract B248: Characterization and preclinical development of LCI-1, a selective and potent Chk1 inhibitor in phase 1 clinical trials

Molecular cancer therapeutics, 2009-12, Vol.8 (12_Supplement), p.B248-B248

2009

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Regulation of the Raf-1 kinase domain by phosphorylation and 14-3-3 association

Biochemical journal, 2000-10, Vol.351 (Pt 1), p.151-159

2000

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Cyclo-oxygenase-2 expression in primary cancers of the lung and bladder compared to normal adjacent tissue

Cancer detection and prevention, 2002-01, Vol.26 (3), p.238-244

2002

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Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues

Molecular and Cellular Biology, 1994-08, Vol.14 (8), p.5318-5325

1994

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In vitro inhibition of Ras-Raf association by short peptides

Biochemical and biophysical research communications, 1998-06, Vol.247 (1), p.176-180

1998

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Regulation of the Raf-1 kinase domain by phosphorylation and 14-3-3 association

Biochemical journal, 2000-10, Vol.351 (1), p.151-159

2000

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Identification of the sites of interaction between c-Raf-1 and Ras-GTP

Oncogene, 1995-04, Vol.10 (7), p.1283-1290

1995

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University of Oklahoma College of Nursing--partnering with ANA to teach safe patient handling and movement

The Oklahoma nurse, 2005-09, Vol.50 (3), p.22

Barnard-York, L Darlene

2005

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Critical Binding and Regulatory Interactions between Ras and Raf Occur through a Small, Stable N-Terminal Domain of Raf and Specific Ras Effector Residues

Molecular and cellular biology, 1994-08, Vol.14 (8), p.5318-5325

1994

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Interstage mortality after the Norwood procedure: Results of the multicenter Single Ventricle Reconstruction trial

The Journal of thoracic and cardiovascular surgery, 2012-10, Vol.144 (4), p.896-906

2012

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Early Developmental Outcome in Children With Hypoplastic Left Heart Syndrome and Related Anomalies The Single Ventricle Reconstruction Trial

Circulation (New York, N.Y.), 2012-05, Vol.125 (17), p.2081-2091

2012

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LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms

Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor

Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy

LY2603618, a selective CHK1 inhibitor, enhances the anti-tumor effect of gemcitabine in xenograft tumor models

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

Cyclooxygenase-2 expression in human pancreatic adenocarcinomas

Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms

Preclinical analyses and phase I evaluation of LY2603618 administered in combination with Pemetrexed and cisplatin in patients with advanced cancer

Heme Compounds in Dinosaur Trabecular Bone

Characterization and preclinical development of LY2603618: a selective and potent Chkl inhibitor

Abstract A108: LY2606368, a second generation Chk1 inhibitor, inhibits growth of ovarian carcinoma xenografts either as monotherapy or in combination with standard-of-care agents

In VitroInhibition of Ras–Raf Association by Short Peptides

Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling

Abstract A49: Circulating tumor cell (CTC) assay development for detection of H2AX as a clinical pharmacodynamic (PD) marker for Chk1 kinase inhibitors

Abstract B248: Characterization and preclinical development of LCI-1, a selective and potent Chk1 inhibitor in phase 1 clinical trials

Regulation of the Raf-1 kinase domain by phosphorylation and 14-3-3 association

Cyclo-oxygenase-2 expression in primary cancers of the lung and bladder compared to normal adjacent tissue

Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues

In vitro inhibition of Ras-Raf association by short peptides

Regulation of the Raf-1 kinase domain by phosphorylation and 14-3-3 association

Identification of the sites of interaction between c-Raf-1 and Ras-GTP

University of Oklahoma College of Nursing--partnering with ANA to teach safe patient handling and movement

Critical Binding and Regulatory Interactions between Ras and Raf Occur through a Small, Stable N-Terminal Domain of Raf and Specific Ras Effector Residues

Interstage mortality after the Norwood procedure: Results of the multicenter Single Ventricle Reconstruction trial

Early Developmental Outcome in Children With Hypoplastic Left Heart Syndrome and Related Anomalies The Single Ventricle Reconstruction Trial

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