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Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice

Experimental gerontology, 2016-10, Vol.83, p.130-138

2016

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Free radicals and aging

Trends in neurosciences (Regular ed.), 2004-10, Vol.27 (10), p.595-600

Barja, Gustavo

2004

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Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart

The FASEB journal, 2001-07, Vol.15 (9), p.1589-1591

2001

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Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction

Journal of bioenergetics and biomembranes, 2015-06, Vol.47 (3), p.199-208

2015

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Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart

American journal of physiology. Regulatory, integrative and comparative physiology, 2003-02, Vol.284 (2), p.474-R480

2003

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Localization of the site of oxygen radical generation inside the complex I of heart and nonsynaptic brain mammalian mitochondria

Journal of bioenergetics and biomembranes, 2000-12, Vol.32 (6), p.609-615

2000

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The flux of free radical attack through mitochondrial DNA is related to aging rate

Aging (Milan, Italy), 2000-10, Vol.12 (5), p.342-355

Barja, G

2000

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Effects of fasting on oxidative stress in rat liver mitochondria

Free radical research, 2006-04, Vol.40 (4), p.339-347

2006

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Sites and mechanisms responsible for the low rate of free radical production of heart mitochondria in the long-lived pigeon

Mechanisms of ageing and development, 1997-11, Vol.98 (2), p.95-111

1997

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Localization at complex I and mechanism of the higher free radical production of brain nonsynaptic mitochondria in the short-lived rat than in the longevous pigeon

Journal of bioenergetics and biomembranes, 1998-06, Vol.30 (3), p.235-243

1998

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H2O2 production of heart mitochondria and aging rate are slower in canaries and parakeets than in mice : sites of free radical generation and mechanisms involved

Mechanisms of ageing and development, 1998-06, Vol.103 (2), p.133-146

1998

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Aging in vertebrates, and the effect of caloric restriction: a mitochondrial free radical production–DNA damage mechanism?

Biological reviews of the Cambridge Philosophical Society, 2004-05, Vol.79 (2), p.235-251

Barja, Gustavo

2004

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Reduced apurinic/apyrimidinic endonuclease 1 activity and increased DNA damage in mitochondria are related to enhanced apoptosis and inflammation in the brain of senescence- accelerated P8 mice (SAMP8)

Biogerontology (Dordrecht), 2016-04, Vol.17 (2), p.325-335

2016

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Carbohydrate restriction does not change mitochondrial free radical generation and oxidative DNA damage

Journal of bioenergetics and biomembranes, 2006-12, Vol.38 (5-6), p.327-333

2006

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The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach

Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 1998-04, Vol.168 (3), p.149-158

1998

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Mitochondrial oxygen radical generation and leak: sites of production in states 4 and 3, organ specificity, and relation to aging and longevity

Journal of bioenergetics and biomembranes, 1999-08, Vol.31 (4), p.347-366

Barja, G

1999

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Rate of generation of oxidative stress-related damage and animal longevity

Free Radical Biology and Medicine, 2002-11, Vol.33 (9), p.1167-1172

Barja, Gustavo

2002

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Endogenous oxidative stress: relationship to aging, longevity and caloric restriction

Ageing research reviews, 2002-06, Vol.1 (3), p.397

Barja, Gustavo

2002

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Minireview: The Role of Oxidative Stress in Relation to Caloric Restriction and Longevity

Endocrinology (Philadelphia), 2005-09, Vol.146 (9), p.3713-3717

2005

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The quantitative measurement of H2O2 generation in isolated mitochondria

Journal of bioenergetics and biomembranes, 2002-06, Vol.34 (3), p.227-233

Barja, Gustavo

2002

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Mitochondrial Free Radical Production and Aging in Mammals and Birds

Annals of the New York Academy of Sciences, 1998-11, Vol.854 (1), p.224-238

BARJA, GUSTAVO

1998

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ADP-regulation of mitochondrial free radical production is different with complex I- or complex II-linked substrates: implications for the exercise paradox and brain hypermetabolism

Journal of bioenergetics and biomembranes, 1997-06, Vol.29 (3), p.241-249

1997

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Effect of insulin and growth hormone on rat heart and liver oxidative stress in control and caloric restricted animals

Biogerontology (Dordrecht), 2005, Vol.6 (1), p.15-26

2005

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Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals

The FASEB journal, 2000-02, Vol.14 (2), p.312-318

2000

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8-oxo-deoxyguanosine levels in heart and brain mitochondrial and nuclear DNA of two mammals and three birds in relation to their different rates of aging

Aging (Milan, Italy), 1999-10, Vol.11 (5), p.294-300

1999

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Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice

Free radicals and aging

Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart

Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction

Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart

Localization of the site of oxygen radical generation inside the complex I of heart and nonsynaptic brain mammalian mitochondria

The flux of free radical attack through mitochondrial DNA is related to aging rate

Effects of fasting on oxidative stress in rat liver mitochondria

Sites and mechanisms responsible for the low rate of free radical production of heart mitochondria in the long-lived pigeon

Localization at complex I and mechanism of the higher free radical production of brain nonsynaptic mitochondria in the short-lived rat than in the longevous pigeon

H2O2 production of heart mitochondria and aging rate are slower in canaries and parakeets than in mice : sites of free radical generation and mechanisms involved

Aging in vertebrates, and the effect of caloric restriction: a mitochondrial free radical production–DNA damage mechanism?

Reduced apurinic/apyrimidinic endonuclease 1 activity and increased DNA damage in mitochondria are related to enhanced apoptosis and inflammation in the brain of senescence- accelerated P8 mice (SAMP8)

Carbohydrate restriction does not change mitochondrial free radical generation and oxidative DNA damage

The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach

Mitochondrial oxygen radical generation and leak: sites of production in states 4 and 3, organ specificity, and relation to aging and longevity

Rate of generation of oxidative stress-related damage and animal longevity

Endogenous oxidative stress: relationship to aging, longevity and caloric restriction

Minireview: The Role of Oxidative Stress in Relation to Caloric Restriction and Longevity

The quantitative measurement of H2O2 generation in isolated mitochondria

Mitochondrial Free Radical Production and Aging in Mammals and Birds

ADP-regulation of mitochondrial free radical production is different with complex I- or complex II-linked substrates: implications for the exercise paradox and brain hypermetabolism

Effect of insulin and growth hormone on rat heart and liver oxidative stress in control and caloric restricted animals

Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals

8-oxo-deoxyguanosine levels in heart and brain mitochondrial and nuclear DNA of two mammals and three birds in relation to their different rates of aging

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