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Synthesis of Heterobifunctional Protein Fusions Using Copper-Free Click Chemistry and the Aldehyde Tag

Angewandte Chemie (International ed.), 2012-04, Vol.51 (17), p.4161-4165

International ed. in English, 2012

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Maytansine-bearing antibody-drug conjugates induce in vitro hallmarks of immunogenic cell death selectively in antigen-positive target cells

Oncoimmunology, 2019-01, Vol.8 (4), p.e1565859-e1565859

2019

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Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper

Drug metabolism and disposition, 2016-05, Vol.44 (5), p.617-623

2016

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The phenomenology of niche evolution via quantitative traits in a ‘black-hole’ sink

Proceedings of the Royal Society. B, Biological sciences, 2003-01, Vol.270 (1511), p.215-224

2003

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Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer

Antibodies (Basel), 2019-11, Vol.8 (4), p.54

2019

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Aldehyde Tag Coupled with HIPS Chemistry Enables the Production of ADCs Conjugated Site-Specifically to Different Antibody Regions with Distinct in Vivo Efficacy and PK Outcomes

Bioconjugate chemistry, 2014-07, Vol.25 (7), p.1331-1341

2014

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Leveraging Formylglycine-Generating Enzyme for Production of Site-Specifically Modified Bioconjugates

Methods in molecular biology (Clifton, N.J.), 2018, Vol.1728, p.3

2018

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Tandem-Cleavage Linkers Improve the In Vivo Stability and Tolerability of Antibody–Drug Conjugates

Bioconjugate chemistry, 2021-04, Vol.32 (4), p.746-754

2021

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Site-Specific Bioconjugation Using SMARTag ® Technology: A Practical and Effective Chemoenzymatic Approach to Generate Antibody-Drug Conjugates

Methods in molecular biology (Clifton, N.J.), 2019, Vol.2033, p.131

2019

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Hydrazino-Pictet-Spengler Ligation as a Biocompatible Method for the Generation of Stable Protein Conjugates

Bioconjugate chemistry, 2013-06, Vol.24 (6), p.846-851

2013

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CRISPR-Cas9 screens identify regulators of antibody-drug conjugate toxicity

Nature chemical biology, 2019-10, Vol.15 (10), p.949-958

2019

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Use of DBS sample collection to determine circulating drug concentrations in clinical trials: practicalities and considerations

Bioanalysis, 2010-08, Vol.2 (8), p.1515-1522

2010

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Systematic LC/MS/MS Investigations for the IND-Enabling Extended Characterization of Antibody–Drug Conjugate Modifications

Antibodies (Basel), 2018-12, Vol.7 (4), p.40

2018

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Reconstitution of Formylglycine-generating Enzyme with Copper(II) for Aldehyde Tag Conversion

The Journal of biological chemistry, 2015-06, Vol.290 (25), p.15730-15745

2015

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A Novel HER2-targeted Antibody–drug Conjugate Offers the Possibility of Clinical Dosing at Trastuzumab-equivalent Exposure Levels

Molecular cancer therapeutics, 2020-09, Vol.19 (9), p.1866-1874

2020

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A DFT Study of the Interresidue Dependencies of Scalar J-Coupling and Magnetic Shielding in the Hydrogen-Bonding Regions of a DNA Triplex

Journal of the American Chemical Society, 2001-05, Vol.123 (17), p.4014-4022

2001

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Effects of Compost on the Chemistry of an Urban Upper Piedmont South Carolina Soil

Communications in Soil Science and Plant Analysis, 2015-12, Vol.46 (22), p.2787-2797

2015

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Hydrophilic Sequence-Defined Cross-Linkers for Antibody–Drug Conjugates

Bioconjugate chemistry, 2019-11, Vol.30 (11), p.2982-2988

2019

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A simple LC/MRM–MS-based method to quantify free linker-payload in antibody-drug conjugate preparations

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016-10, Vol.1032, p.144-148

2016

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CAT-02-106, a Site-Specifically Conjugated Anti-CD22 Antibody Bearing an MDR1-Resistant Maytansine Payload Yields Excellent Efficacy and Safety in Preclinical Models

Molecular cancer therapeutics, 2018-01, Vol.17 (1), p.161-168

2018

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The exomer coat complex transports Fus1p to the plasma membrane via a novel plasma membrane sorting signal in yeast

Molecular biology of the cell, 2009-12, Vol.20 (23), p.4985-4996

2009

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Exploring the effects of linker composition on site-specifically modified antibody–drug conjugates

European journal of medicinal chemistry, 2014-12, Vol.88, p.3-9

2014

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Structural Dependencies of Interresidue Scalar Coupling h3JNC‘ and Donor 1H Chemical Shifts in the Hydrogen Bonding Regions of Proteins

Journal of the American Chemical Society, 2002-04, Vol.124 (15), p.4158-4168

BARFIELD, Michael

2002

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Multiple acquired portosystemic shunts in a cat secondary to chronic diaphragmatic rupture

JFMS open reports, 2015, Vol.1 (1), p.2055116915585020

2015

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Generating aldehyde-tagged antibodies with high titers and high formylglycine yields by supplementing culture media with copper(II)

BMC biotechnology, 2016-02, Vol.16 (23), p.23-23, Article 23

2016

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Synthesis of Heterobifunctional Protein Fusions Using Copper-Free Click Chemistry and the Aldehyde Tag

Maytansine-bearing antibody-drug conjugates induce in vitro hallmarks of immunogenic cell death selectively in antigen-positive target cells

Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper

The phenomenology of niche evolution via quantitative traits in a ‘black-hole’ sink

Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer

Aldehyde Tag Coupled with HIPS Chemistry Enables the Production of ADCs Conjugated Site-Specifically to Different Antibody Regions with Distinct in Vivo Efficacy and PK Outcomes

Leveraging Formylglycine-Generating Enzyme for Production of Site-Specifically Modified Bioconjugates

Tandem-Cleavage Linkers Improve the In Vivo Stability and Tolerability of Antibody–Drug Conjugates

Site-Specific Bioconjugation Using SMARTag ® Technology: A Practical and Effective Chemoenzymatic Approach to Generate Antibody-Drug Conjugates

Hydrazino-Pictet-Spengler Ligation as a Biocompatible Method for the Generation of Stable Protein Conjugates

CRISPR-Cas9 screens identify regulators of antibody-drug conjugate toxicity

Use of DBS sample collection to determine circulating drug concentrations in clinical trials: practicalities and considerations

Systematic LC/MS/MS Investigations for the IND-Enabling Extended Characterization of Antibody–Drug Conjugate Modifications

Reconstitution of Formylglycine-generating Enzyme with Copper(II) for Aldehyde Tag Conversion

A Novel HER2-targeted Antibody–drug Conjugate Offers the Possibility of Clinical Dosing at Trastuzumab-equivalent Exposure Levels

A DFT Study of the Interresidue Dependencies of Scalar J-Coupling and Magnetic Shielding in the Hydrogen-Bonding Regions of a DNA Triplex

Effects of Compost on the Chemistry of an Urban Upper Piedmont South Carolina Soil

Hydrophilic Sequence-Defined Cross-Linkers for Antibody–Drug Conjugates

A simple LC/MRM–MS-based method to quantify free linker-payload in antibody-drug conjugate preparations

CAT-02-106, a Site-Specifically Conjugated Anti-CD22 Antibody Bearing an MDR1-Resistant Maytansine Payload Yields Excellent Efficacy and Safety in Preclinical Models

The exomer coat complex transports Fus1p to the plasma membrane via a novel plasma membrane sorting signal in yeast

Exploring the effects of linker composition on site-specifically modified antibody–drug conjugates

Structural Dependencies of Interresidue Scalar Coupling h3JNC‘ and Donor 1H Chemical Shifts in the Hydrogen Bonding Regions of Proteins

Multiple acquired portosystemic shunts in a cat secondary to chronic diaphragmatic rupture

Generating aldehyde-tagged antibodies with high titers and high formylglycine yields by supplementing culture media with copper(II)

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