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Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb

Nucleic acids research, 2016-09, Vol.44 (16), p.7527

2016

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Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

Nucleic acids research, 2015-03, Vol.43 (5), p.2575

2015

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The two sides of Tat

eLife, 2016-01, Vol.5, p.e12686-e12686

2016

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Cap-binding Protein Complex Links Pre-mRNA Capping to Transcription Elongation and Alternative Splicing through Positive Transcription Elongation Factor b (P-TEFb)

The Journal of biological chemistry, 2011-07, Vol.286 (26), p.22758-22768

2011

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HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcription

PLoS pathogens, 2007-10, Vol.3 (10), p.1459-1469

2007

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7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development

Proceedings of the National Academy of Sciences - PNAS, 2009-05, Vol.106 (19), p.7798-7803

2009

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P-TEFb stimulates transcription elongation and pre-mRNA splicing through multilateral mechanisms

RNA biology, 2010-03, Vol.7 (2), p.145-150

2010

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A new paradigm in eukaryotic biology: HIV Tat and the control of transcriptional elongation

PLoS biology, 2005-02, Vol.3 (2), p.e76-e76

2005

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Identification of a Cyclin T-Binding Domain in Hexim1 and Biochemical Analysis of Its Binding Competition with HIV-1 Tat

The Journal of biological chemistry, 2005-07, Vol.280 (26), p.24968-24977

2005

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Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb

Proceedings of the National Academy of Sciences - PNAS, 2007-09, Vol.104 (36), p.14312-14317

2007

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A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb

Genes & development, 2003-03, Vol.17 (6), p.748-758

2003

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Tat Transactivation: A Model for the Regulation of Eukaryotic Transcriptional Elongation

Virology, 1999-11, Vol.264 (2), p.245-253

1999

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Kick-sTARting HIV-1 transcription elongation by 7SK snRNP deporTATion

Nature structural & molecular biology, 2010-08, Vol.17 (8), p.928

2010

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Mutual relationships between transcription and pre-mRNA processing in the synthesis of mRNA

Wiley interdisciplinary reviews. RNA, 2013-03, Vol.4 (2), p.139-154

2013

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Ubiquitylation of Cdk9 by Skp2 Facilitates Optimal Tat Transactivation

Journal of Virology, 2005-09, Vol.79 (17), p.11135-11141

2005

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The Interlocking Lives of LARP7: Fine-Tuning Transcription, RNA Modification, and Splicing through Multiple Non-coding RNAs

Molecular cell, 2020-04, Vol.78 (1), p.5-8

2020

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P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress

Molecular cell, 2019-04, Vol.74 (2), p.254-267.e10

2019

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PKC phosphorylates HEXIM1 and regulates P-TEFb activity

Nucleic acids research, 2012-10, Vol.40 (18), p.9160

2012

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NF-κB Binds P-TEFb to Stimulate Transcriptional Elongation by RNA Polymerase II

Molecular cell, 2001-08, Vol.8 (2), p.327-337

2001

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Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription

Nucleic acids research, 2007-03, Vol.35 (6), p.2003

2007

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Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes

Biochimica et biophysica acta, 2016-11, Vol.1859 (11), p.1440-1448

2016

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P-TEFb promotes cell survival upon p53 activation by suppressing intrinsic apoptosis pathway

Nucleic acids research, 2023-02, Vol.51 (4), p.1687

2023

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Binding of Tat to TAR and Recruitment of Positive Transcription Elongation Factor b Occur Independently in Bovine Immunodeficiency Virus

Journal of Virology, 2000-07, Vol.74 (13), p.6039-6044

2000

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Abstract MIP-043: OVARIAN CARCINOMA CDK12 MUTATIONS IMPAIR GENE-SPECIFIC POL II ELONGATION AND FAITHFUL REPAIR OF DNA DOUBLE STRAND BREAKS

Clinical cancer research, 2017-06, Vol.23 (11_Supplement), p.MIP-043-MIP-043

2017

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Abstract AS21: Ovarian carcinoma CDK12 mutations misregulate DNA repair genes via deficient formation and function of the Cdk12/CycK complex

Clinical cancer research, 2015-08, Vol.21 (16_Supplement), p.AS21-AS21

2015

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Transcription, Genetic
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Positive Transcriptional Elongation Factor B - Metabolism
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Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb

Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

The two sides of Tat

Cap-binding Protein Complex Links Pre-mRNA Capping to Transcription Elongation and Alternative Splicing through Positive Transcription Elongation Factor b (P-TEFb)

HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcription

7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development

P-TEFb stimulates transcription elongation and pre-mRNA splicing through multilateral mechanisms

A new paradigm in eukaryotic biology: HIV Tat and the control of transcriptional elongation

Identification of a Cyclin T-Binding Domain in Hexim1 and Biochemical Analysis of Its Binding Competition with HIV-1 Tat

Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb

A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb

Tat Transactivation: A Model for the Regulation of Eukaryotic Transcriptional Elongation

Kick-sTARting HIV-1 transcription elongation by 7SK snRNP deporTATion

Mutual relationships between transcription and pre-mRNA processing in the synthesis of mRNA

Ubiquitylation of Cdk9 by Skp2 Facilitates Optimal Tat Transactivation

The Interlocking Lives of LARP7: Fine-Tuning Transcription, RNA Modification, and Splicing through Multiple Non-coding RNAs

P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress

PKC phosphorylates HEXIM1 and regulates P-TEFb activity

NF-κB Binds P-TEFb to Stimulate Transcriptional Elongation by RNA Polymerase II

Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription

Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes

P-TEFb promotes cell survival upon p53 activation by suppressing intrinsic apoptosis pathway

Binding of Tat to TAR and Recruitment of Positive Transcription Elongation Factor b Occur Independently in Bovine Immunodeficiency Virus

Abstract MIP-043: OVARIAN CARCINOMA CDK12 MUTATIONS IMPAIR GENE-SPECIFIC POL II ELONGATION AND FAITHFUL REPAIR OF DNA DOUBLE STRAND BREAKS

Abstract AS21: Ovarian carcinoma CDK12 mutations misregulate DNA repair genes via deficient formation and function of the Cdk12/CycK complex

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