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The oxazolidinones: past, present, and future

Annals of the New York Academy of Sciences, 2011-12, Vol.1241 (1), p.48-70

2011

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Identification of a 1,2,4-Oxadiazole with Potent and Specific Activity against Clostridioides difficile, the Causative Bacterium of C. difficile Infection, an Urgent Public Health Threat

Journal of medicinal chemistry, 2023-10, Vol.66 (20), p.13888-13890

Barbachyn, Michael R.

2023

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Oxazolidinone Structure-Activity Relationships Leading to Linezolid

Angewandte Chemie International Edition, 2003-05, Vol.42 (18), p.2010-2023

2003

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Linezolid (ZYVOX), the First Member of a Completely New Class of Antibacterial Agents for Treatment of Serious Gram-Positive Infections

Journal of medicinal chemistry, 2008-04, Vol.51 (7), p.1981-1990

2008

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Synthesis of (−)-PNU-286607 by Asymmetric Cyclization of Alkylidene Barbiturates

Journal of the American Chemical Society, 2009-03, Vol.131 (11), p.3991-3997

2009

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Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host environment

mBio, 2023-12, Vol.14 (6), p.e0249223

2023

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Synthesis and Antibacterial Activity of U-100592 and U-100766, Two Oxazolidinone Antibacterial Agents for the Potential Treatment of Multidrug-Resistant Gram-Positive Bacterial Infections

Journal of medicinal chemistry, 1996-02, Vol.39 (3), p.673-679

1996

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The Synthesis of Functionalized 3‑Aryl- and 3‑Heteroaryloxazolidin-2-ones and Tetrahydro-3-aryl-1,3-oxazin-2-ones via the Iodocyclocarbamation Reaction: Access to Privileged Chemical Structures and Scope and Limitations of the Method

Journal of organic chemistry, 2020-05, Vol.85 (10), p.6323-6337

2020

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Identification of Phenylisoxazolines as Novel and Viable Antibacterial Agents Active against Gram-Positive Pathogens

Journal of medicinal chemistry, 2003-01, Vol.46 (2), p.284-302

2003

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5-(2-Pyrimidinyl)-imidazo[1,2- a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (18), p.5302-5306

2009

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Piperazinyl Oxazolidinone Antibacterial Agents Containing a Pyridine, Diazene, or Triazene Heteroaromatic Ring

Journal of medicinal chemistry, 1998-09, Vol.41 (19), p.3727-3735

1998

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Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors

Antimicrobial Agents and Chemotherapy, 2008-08, Vol.52 (8), p.2806-2812

2008

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Novel oxazolidinone–quinolone hybrid antimicrobials

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (23), p.4213-4216

2003

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Identification of a Novel Oxazolidinone (U-100480) with Potent Antimycobacterial Activity

Journal of medicinal chemistry, 1996-02, Vol.39 (3), p.680-685

1996

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Substituent Effects on the Antibacterial Activity of Nitrogen−Carbon-Linked (Azolylphenyl)oxazolidinones with Expanded Activity Against the Fastidious Gram-Negative Organisms Haemophilus influenzae and Moraxella catarrhalis

Journal of medicinal chemistry, 2000-03, Vol.43 (5), p.953-970

2000

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The Oxazolidinones

Antibacterials, 2018, Vol.26, p.97-121

2018

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The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (23), p.4235-4239

2003

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Efficient synthesis of 1-(trialkylstannyl)- and 1-(triarylstannyl)bicyclo[1.1.1]pentanes

Journal of organic chemistry, 1993-11, Vol.58 (23), p.6505-6508

1993

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Carbon–carbon-linked (pyrazolylphenyl)oxazolidinones with antibacterial activity against multiple drug resistant gram-positive and fastidious gram-negative bacteria

Bioorganic & medicinal chemistry, 2001-12, Vol.9 (12), p.3243-3253

2001

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In vitro activities of U-100592 and U-100766, novel oxazolidinone antibacterial agents

Antimicrobial Agents and Chemotherapy, 1996-04, Vol.40 (4), p.839-845

1996

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Regioselective Metalation of Fluoroanilines. An Application to the Synthesis of Fluorinated Oxazolidinone Antibacterial Agents

Journal of organic chemistry, 1995-08, Vol.60 (16), p.5255-5261

1995

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beta.-Hydroxysulfoximine-directed Simmons-Smith cyclopropanations. Synthesis of (-)- and (+)-thujopsene

Journal of the American Chemical Society, 1982-07, Vol.104 (15), p.4290-4291

1982

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In vivo activities of U-100592 and U-100766, novel oxazolidinone antimicrobial agents, against experimental bacterial infections

Antimicrobial Agents and Chemotherapy, 1996-06, Vol.40 (6), p.1508-1513

1996

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Synthesis and antibacterial activity of new tropone-substituted phenyloxazolidinone antibacterial agents 2. Modification of the phenyl ring — the potentiating effect of fluorine substitution on in vivo activity

Bioorganic & medicinal chemistry letters, 1996-05, Vol.6 (9), p.1009-1014

1996

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The oxazolidinones: past, present, and future

Identification of a 1,2,4-Oxadiazole with Potent and Specific Activity against Clostridioides difficile, the Causative Bacterium of C. difficile Infection, an Urgent Public Health Threat

Oxazolidinone Structure-Activity Relationships Leading to Linezolid

Linezolid (ZYVOX), the First Member of a Completely New Class of Antibacterial Agents for Treatment of Serious Gram-Positive Infections

Synthesis of (−)-PNU-286607 by Asymmetric Cyclization of Alkylidene Barbiturates

Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host environment

Synthesis and Antibacterial Activity of U-100592 and U-100766, Two Oxazolidinone Antibacterial Agents for the Potential Treatment of Multidrug-Resistant Gram-Positive Bacterial Infections

The Synthesis of Functionalized 3‑Aryl- and 3‑Heteroaryloxazolidin-2-ones and Tetrahydro-3-aryl-1,3-oxazin-2-ones via the Iodocyclocarbamation Reaction: Access to Privileged Chemical Structures and Scope and Limitations of the Method

Identification of Phenylisoxazolines as Novel and Viable Antibacterial Agents Active against Gram-Positive Pathogens

5-(2-Pyrimidinyl)-imidazo[1,2- a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV

Piperazinyl Oxazolidinone Antibacterial Agents Containing a Pyridine, Diazene, or Triazene Heteroaromatic Ring

Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors

Novel oxazolidinone–quinolone hybrid antimicrobials

Identification of a Novel Oxazolidinone (U-100480) with Potent Antimycobacterial Activity

Antibacterial Oxazolidinones Possessing a Novel C-5 Side Chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic Acid Amide (PF-00422602), a New Lead Compound

Substituent Effects on the Antibacterial Activity of Nitrogen−Carbon-Linked (Azolylphenyl)oxazolidinones with Expanded Activity Against the Fastidious Gram-Negative Organisms Haemophilus influenzae and Moraxella catarrhalis

The Oxazolidinones

The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones

Efficient synthesis of 1-(trialkylstannyl)- and 1-(triarylstannyl)bicyclo[1.1.1]pentanes

Carbon–carbon-linked (pyrazolylphenyl)oxazolidinones with antibacterial activity against multiple drug resistant gram-positive and fastidious gram-negative bacteria

In vitro activities of U-100592 and U-100766, novel oxazolidinone antibacterial agents

Regioselective Metalation of Fluoroanilines. An Application to the Synthesis of Fluorinated Oxazolidinone Antibacterial Agents

beta.-Hydroxysulfoximine-directed Simmons-Smith cyclopropanations. Synthesis of (-)- and (+)-thujopsene

In vivo activities of U-100592 and U-100766, novel oxazolidinone antimicrobial agents, against experimental bacterial infections

Synthesis and antibacterial activity of new tropone-substituted phenyloxazolidinone antibacterial agents 2. Modification of the phenyl ring — the potentiating effect of fluorine substitution on in vivo activity

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