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Preclinical Development of MGC018, a Duocarmycin-based Antibody-drug Conjugate Targeting B7-H3 for Solid Cancer

Molecular cancer therapeutics, 2020-11, Vol.19 (11), p.2235-2244

2020

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Abstract 1533: IMGC936, a first-in-class ADAM9-targeting antibody-drug conjugate, demonstrates promising anti-tumor activity

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.1533-1533

2019

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Activation of Ribosomal RNA Transcription by Hepatitis C Virus Involves Upstream Binding Factor Phosphorylation via Induction of Cyclin D1

Cancer research (Chicago, Ill.), 2009-03, Vol.69 (5), p.2057-2064

2009

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Multispecific, Multivalent Antibody‐Based Molecules Engineered on the DART® and TRIDENTTM Platforms

Current Protocols in Immunology, 2020-06, Vol.129 (1), p.n/a

2020

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Site-Specific, Thiol-Mediated Conjugation of Fluorescent Probes to Cysteine-Modified Diabodies Targeting CD20 or HER2

Bioconjugate chemistry, 2008-12, Vol.19 (12), p.2527-2534

2008

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A Peptide from Autoantigen La Blocks Poliovirus and Hepatitis C Virus Cap-Independent Translation and Reveals a Single Tyrosine Critical for La RNA Binding and Translation Stimulation

Journal of Virology, 2004-04, Vol.78 (7), p.3763-3776

2004

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Effector Cell Recruitment with Novel Fv-based Dual-affinity Re-targeting Protein Leads to Potent Tumor Cytolysis and in Vivo B-cell Depletion

Journal of molecular biology, 2010-06, Vol.399 (3), p.436-449

2010

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Preclinical Evaluation of IMGC936, a Next Generation Maytansinoid-based Antibody-drug Conjugate Targeting ADAM9-expressing Tumors

Molecular cancer therapeutics, 2022-07, Vol.21 (7), p.1047-1059

2022

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Abstract 5203: MGC018, a duocarmycin-based antibody-drug conjugate targeting B7-H3, exhibits immunomodulatory activity and enhanced antitumor activity in combination with checkpoint inhibitors

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.5203-5203

2020

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Abstract 1489: Development of a humanized ROR1 x CD3 bispecific DART® molecule for the treatment of solid and liquid tumors

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.1489-1489

2016

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Abstract 42: Preclinical development of a duocarmycin-based antibody-drug conjugate targeting B7-H3 for solid cancer

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.42-42

2017

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Abstract 37: Novel antibody-drug conjugates targeting ADAM9-expressing solid tumors demonstrate potent preclinical activity

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.37-37

2017

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Abstract 820: Preclinical development of MGC018, a duocarmycin-based antibody-drug conjugate targeting B7-H3 for solid cancer

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.820-820

2018

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Multispecific, Multivalent Antibody‐Based Molecules Engineered on the DART® and TRIDENT TM Platforms

Current Protocols in Immunology, 2020-06, Vol.129 (1)

2020

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Abstract 38: Target validation, antibody discovery and preclinical data supporting ADAM9 as an antibody-drug conjugate therapeutic target for solid tumors

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.38-38

2017

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Abstract 1201: Anti-B7-H3 antibody-drug conjugates as potential therapeutics for solid cancer

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.1201-1201

2016

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Cys-diabody Quantum Dot Conjugates (ImmunoQdots) for Cancer Marker Detection

Bioconjugate chemistry, 2009-08, Vol.20 (8), p.1474-1481

2009

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Evaluation of Two Internalizing Carcinoembryonic Antigen Reporter Genes for Molecular Imaging

Molecular imaging and biology, 2011-06, Vol.13 (3), p.526-535

2011

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Metabolic biotinylation of recombinant antibody by biotin ligase retained in the endoplasmic reticulum

Biomolecular engineering, 2007-09, Vol.24 (3), p.283-291

2007

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Non-depleting down-modulation of human B-cells through inhibitory coupling of FcγRIIB (CD32B) and the BCR with bi-specific DART molecules with extended pharmacokinetics. (51.8)

The Journal of immunology (1950), 2012-05, Vol.188 (1_Supplement), p.51-51.8

2012

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Recombinant carcinoembryonic antigen as a reporter gene for molecular imaging

European journal of nuclear medicine and molecular imaging, 2009-01, Vol.36 (1), p.104-114

2009

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Targeting internal ribosome entry site (IRES)-mediated translation to block hepatitis C and other RNA viruses

FEMS Microbiology Letters, 2004-05, Vol.234 (2), p.189-199

2004

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UDP-Galactose 4-Epimerase from Kluyveromyces fragilis: Analysis of Its Hysteretic Behavior during Catalysis

Biochemistry (Easton), 2004-08, Vol.43 (31), p.10212-10223

2004

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Targeting internal ribosome entry site (IRES)-mediated translation to block hepatitis C and other RNA viruses

FEMS microbiology letters, 2006-01, Vol.234 (2), p.189-199

2006

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Engineered Anti-CEA Antibody Fragments and Recombinant Carcinoembryonic Antigen (CEA) As A PET Reporter System

Journal of immunotherapy (1997), 2005-11, Vol.28 (6), p.642

2005

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Preclinical Development of MGC018, a Duocarmycin-based Antibody-drug Conjugate Targeting B7-H3 for Solid Cancer

Abstract 1533: IMGC936, a first-in-class ADAM9-targeting antibody-drug conjugate, demonstrates promising anti-tumor activity

Activation of Ribosomal RNA Transcription by Hepatitis C Virus Involves Upstream Binding Factor Phosphorylation via Induction of Cyclin D1

Multispecific, Multivalent Antibody‐Based Molecules Engineered on the DART® and TRIDENTTM Platforms

Site-Specific, Thiol-Mediated Conjugation of Fluorescent Probes to Cysteine-Modified Diabodies Targeting CD20 or HER2

A Peptide from Autoantigen La Blocks Poliovirus and Hepatitis C Virus Cap-Independent Translation and Reveals a Single Tyrosine Critical for La RNA Binding and Translation Stimulation

Effector Cell Recruitment with Novel Fv-based Dual-affinity Re-targeting Protein Leads to Potent Tumor Cytolysis and in Vivo B-cell Depletion

Preclinical Evaluation of IMGC936, a Next Generation Maytansinoid-based Antibody-drug Conjugate Targeting ADAM9-expressing Tumors

Abstract 5203: MGC018, a duocarmycin-based antibody-drug conjugate targeting B7-H3, exhibits immunomodulatory activity and enhanced antitumor activity in combination with checkpoint inhibitors

Abstract 1489: Development of a humanized ROR1 x CD3 bispecific DART® molecule for the treatment of solid and liquid tumors

Abstract 42: Preclinical development of a duocarmycin-based antibody-drug conjugate targeting B7-H3 for solid cancer

Abstract 37: Novel antibody-drug conjugates targeting ADAM9-expressing solid tumors demonstrate potent preclinical activity

Abstract 820: Preclinical development of MGC018, a duocarmycin-based antibody-drug conjugate targeting B7-H3 for solid cancer

Multispecific, Multivalent Antibody‐Based Molecules Engineered on the DART® and TRIDENT TM Platforms

Abstract 38: Target validation, antibody discovery and preclinical data supporting ADAM9 as an antibody-drug conjugate therapeutic target for solid tumors

Abstract 1201: Anti-B7-H3 antibody-drug conjugates as potential therapeutics for solid cancer

Cys-diabody Quantum Dot Conjugates (ImmunoQdots) for Cancer Marker Detection

Evaluation of Two Internalizing Carcinoembryonic Antigen Reporter Genes for Molecular Imaging

Metabolic biotinylation of recombinant antibody by biotin ligase retained in the endoplasmic reticulum

Non-depleting down-modulation of human B-cells through inhibitory coupling of FcγRIIB (CD32B) and the BCR with bi-specific DART molecules with extended pharmacokinetics. (51.8)

Recombinant carcinoembryonic antigen as a reporter gene for molecular imaging

Targeting internal ribosome entry site (IRES)-mediated translation to block hepatitis C and other RNA viruses

UDP-Galactose 4-Epimerase from Kluyveromyces fragilis: Analysis of Its Hysteretic Behavior during Catalysis

Targeting internal ribosome entry site (IRES)-mediated translation to block hepatitis C and other RNA viruses

Engineered Anti-CEA Antibody Fragments and Recombinant Carcinoembryonic Antigen (CEA) As A PET Reporter System

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